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Thra
Gene Detail
 Symbol
Name
ID
Thra
thyroid hormone receptor alpha
MGI:98742
Synonyms 6430529J03Rik, c-erbAalpha, Erba, Nr1a1, Rvr, T3R[a], T3Ralpha, Thra1, Thra2, TR alpha 1, TR alpha 2
Feature Type protein coding gene
Genetic Map
Chromosome 11
62.58 cM, cytoband D-E
Detailed Genetic Map ± 1 cM


Mapping data(29)
Sequence Map
Chr11:98740638-98769006 bp, + strand
From VEGA annotation of GRCm38

  28369 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37747  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: thyroid hormone receptor
Gene Tree: Thra

Human
homologs
Human Homolog THRA, thyroid hormone receptor, alpha
NCBI Gene ID 7067
neXtProt AC  NX_P10827
Human Synonyms  AR7, c-ERBA-1, CHNG6, EAR7, ERBA, ERBA1, ERB-T-1, NR1A1, THRA1, THRA2
Human Chr (Location)  17q11.2; chr17:40062193-40093867 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human THRA
Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Gene trapped(13) Targeted(13)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation show reduced growth, hypothermia, and intestinal immaturity. Other targeted mutations affect thyroid hormone status, adiposity, growth, heart rate, thermoregulation, fertility, and survival.
 
Interactions
Thra interacts with 120 markers (Mir17, Mir18b, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (71 annotations)
Process cartilage condensation, cytoplasmic sequestering of transcription factor, ...
Component cytoplasm, cytosol, ...
Function chromatin DNA binding, intronic transcription regulatory region DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (190)    Tissues (164)    Images (23)
Theiler Stages: 2, 3, 4, 5, 15, 17, 18, 19, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 171
Northern blot 8
RT-PCR 11
cDNA source data(25)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(38) Genomic(3) cDNA(29) Primer pair(3) Other(3)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000006409 (Evidence)
Ensembl Gene ModelENSMUSG00000058756 (Evidence)
Entrez Gene21833 (Evidence)
NIA Mouse Gene IndexU013309
Consensus CDS ProjectCCDS25362.1
International Mouse Knockout Project StatusThra
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006409 VEGA Gene Model | MGI Sequence Detail 28369 C57BL/6J ±  kb
transcript OTTMUST00000014597 VEGA | MGI Sequence Detail 2452 Not Applicable 
polypeptide OTTMUSP00000006787 VEGA | MGI Sequence Detail 492 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(2) UniProt(2)
Polymorphisms RFLP(8) : SNPs within 2kb(102 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR001723 Steroid hormone receptor
InterPro IPR001728 Thyroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000003428 thyroid hormone receptor alpha
References (Earliest) J:5152 Pizarro O, et al., A study of recombination between the H-2 (histocompatibility) locus and loci closely linked with it in the house mouse. Transplantation. 1970 Mar;9(3):207-18
(Latest) J:209162 Kim DW, et al., A histone deacetylase inhibitor improves hypothyroidism caused by a TRalpha1 mutant. Hum Mol Genet. 2014 May 15;23(10):2651-64
All references(229)
Other
accession IDs
MGD-MRK-15091, MGD-MRK-15092, MGD-MRK-15093, MGD-MRK-19597, MGD-MRK-9569, MGI:2144519, MGI:2441716

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory