Thra
Gene Detail

Symbol Name ID

Thra thyroid hormone receptor alpha MGI:98742

Synonyms

6430529J03Rik, c-erbAalpha, Erba, Nr1a1, Rvr, T3R[a], T3Ralpha, Thra1, Thra2, TR alpha 1, TR alpha 2

Feature Type

protein coding gene

Genetic Map

Chromosome 11

62.58 cM, cytoband D-E
Detailed Genetic Map ± 1 cM


Mapping data(29)

Sequence Map

Chr11:98740638-98769006 bp, + strand From VEGA annotation of GRCm38   28369 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37747  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: thyroid hormone receptor
Gene Tree: Thra

Human homologs

Human Homolog		THRA, thyroid hormone receptor, alpha
NCBI Gene ID		7067
neXtProt AC		NX_P10827
Human Synonyms		AR7, c-ERBA-1, CHNG6, EAR7, ERBA, ERBA1, ERB-T-1, NR1A1, THRA1, THRA2
Human Chr (Location)		17q11.2; chr17:38218446-38250120 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human THRA

Alleles and phenotypes

All alleles(26) : Targeted(13) Gene trapped(13)
 

Homozygotes for a targeted null mutation show reduced growth, hypothermia, and intestinal immaturity. Other targeted mutations affect thyroid hormone status, adiposity, growth, heart rate, thermoregulation, fertility, and survival.

 

Gene Ontology (GO) classifications

All GO classifications: (68 annotations)

Process	cartilage condensation, cytoplasmic sequestering of transcription factor, ...
Component	cytoplasm, cytosol, ...
Function	chromatin DNA binding, intronic transcription regulatory region DNA binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (21 records)
Data Summary: Results (197)    Tissues (169)    Images (23)
Theiler Stages: 2, 3, 4, 5, 15, 17, 18, 19, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	171
Northern blot	8
RT-PCR	18

cDNA source data(25)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(38) Genomic(3) cDNA(29) Primer pair(3) Other(3)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000006409 (Evidence)
Ensembl Gene Model	ENSMUSG00000058756 (Evidence)
Entrez Gene	21833 (Evidence)
NIA Mouse Gene Index	U013309
Consensus CDS Project	CCDS25362.1
International Mouse Knockout Project Status	Thra

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006409	VEGA Gene Model | MGI Sequence Detail	28369	C57BL/6J
transcript	OTTMUST00000014597	VEGA | MGI Sequence Detail	2452	Not Applicable
polypeptide	OTTMUSP00000006787	VEGA | MGI Sequence Detail	492	Not Applicable

All sequences(47) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(8) : SNPs(60 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008946	Nuclear hormone receptor, ligand-binding
InterPro	IPR000536	Nuclear hormone receptor, ligand-binding, core
InterPro	IPR001723	Steroid hormone receptor
InterPro	IPR001728	Thyroid hormone receptor
InterPro	IPR013088	Zinc finger, NHR/GATA-type
InterPro	IPR001628	Zinc finger, nuclear hormone receptor-type
Protein Ontology	PR:000003428	thyroid hormone receptor alpha

References

(Earliest) J:5152 Pizarro O, et al., A study of recombination between the H-2 (histocompatibility) locus and loci closely linked with it in the house mouse. Transplantation. 1970 Mar;9(3):207-18
(Latest) J:194089 Peeters RP, et al., Cerebellar abnormalities in mice lacking type 3 deiodinase and partial reversal of phenotype by deletion of thyroid hormone receptor alpha1. Endocrinology. 2013 Jan;154(1):550-61
All references(220)

Other accession IDs

MGD-MRK-15091, MGD-MRK-15092, MGD-MRK-15093, MGD-MRK-19597, MGD-MRK-9569, MGI:2144519, MGI:2441716