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Thra Gene Detail
Summary
  • Symbol
    Thra
  • Name
    thyroid hormone receptor alpha
  • Synonyms
    6430529J03Rik, c-erbAalpha, Erba, Nr1a1, Rvr, T3R[a], T3Ralpha, Thra1, Thra2, TR alpha 1, TR alpha 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98742
    NCBI Gene: 21833
  • Gene Overview
    MyGene.info: THRA
Location & Maps
more
  • Sequence Map
    Chr11:98740638-98769006 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28369 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    THRA, thyroid hormone receptor, alpha
  • Vertebrate Orthologs
    9
  • Human Ortholog
    THRA, thyroid hormone receptor, alpha
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AR7, c-ERBA-1, CHNG6, EAR7, ERBA, ERBA1, ERB-T-1, NR1A1, THRA1, THRA2
  • Links
    NCBI Gene ID: 7067
    neXtProt AC: NX_P10827

  • Chr Location
    17q11.2; chr17:40062193-40093867 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human THRA associations

Human Disease Mouse Models
       Hypothyroidism, Congenital, Nongoitrous, 6; CHNG6   OMIM: 614450
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    139 phenotypes from 12 alleles in 15 genetic backgrounds
    47 phenotypes from multigenic genotypes
    134 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    33
  • Gene trapped
    13
  • Targeted
    15
  • Transgenic
    5
  • Genomic Mutations
    1 involving Thra
  • Incidental Mutations
Mutations in this gene result in diverse phenotypes depending on the location and severity of the mutation. Observed phenotypes may include alterations in thyroid physiology, intestinal remodeling, cerebellum development, bone growth, cardiac function, thermogenesis, and fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006409 VEGA Gene Model | MGI Sequence Detail 28369 C57BL/6J ±  kb
transcript OTTMUST00000014597 VEGA | MGI Sequence Detail 2452 Not Applicable  
polypeptide OTTMUSP00000006787 VEGA | MGI Sequence Detail 492 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    102 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000003428 thyroid hormone receptor alpha
  • InterPro Domains
    IPR001723 Nuclear hormone receptor
    IPR000536 Nuclear hormone receptor, ligand-binding domain
    IPR001728 Thyroid hormone receptor
    IPR013088 Zinc finger, NHR/GATA-type
    IPR001628 Zinc finger, nuclear hormone receptor-type
Molecular
Reagents
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  • All nucleic 38
    Genomic 3
    cDNA 29
    Primer pair 3
    Other 3

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-15091, MGD-MRK-15092, MGD-MRK-15093, MGD-MRK-19597, MGD-MRK-9569, MGI:2144519, MGI:2441716
References
more
  • Summaries
    All 233
    Developmental Gene Expression 24
    Gene Ontology 25
    Phenotypes 134
  • Earliest
    J:5152 Pizarro O, et al., A study of recombination between the H-2 (histocompatibility) locus and loci closely linked with it in the house mouse. Transplantation. 1970 Mar;9(3):207-18
  • Latest
    J:228576 Singh BK, et al., Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition. J Biol Chem. 2016 Jan 1;291(1):198-214

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory