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Thra
Gene Detail
Symbol

Name
ID
Thra
thyroid hormone receptor alpha
MGI:98742
Synonyms
6430529J03Rik, c-erbAalpha, Erba, Nr1a1, Rvr, T3R[a], T3Ralpha, Thra1, Thra2, TR alpha 1, TR alpha 2
Feature Type
protein coding gene
Genetic Map
Chromosome 11
62.58 cM, cytoband D-E
Detailed Genetic Map ± 1 cM


Mapping data(29)
Sequence Map
Chr11:98740638-98769006 bp, + strand
From VEGA annotation of GRCm38

  28369 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37747  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: THRA
Protein SuperFamily: thyroid hormone receptor
Gene Tree: Thra

Human
homologs
THRA, thyroid hormone receptor, alpha
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 7067
neXtProt AC: NX_P10827

Human Synonyms: AR7, c-ERBA-1, CHNG6, EAR7, ERBA, ERBA1, ERB-T-1, NR1A1, THRA1, THRA2

Human Chr (Location): 17q11.2; chr17:40062193-40093867 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human THRA

Mutations,
alleles, and
phenotypes
All mutations/alleles(28) : Gene trapped(13) Targeted(15)
Genomic Mutations involving Thra (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Thra interacts with 120 markers (Mir17, Mir18b, Mir19a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (23 records)
Data Summary: Results (190)    Tissues (165)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 171
Northern blot 8
RT-PCR 11
cDNA source data(25)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase thra ; ZFIN thraa, thrab    NEW 
Molecular
reagents
All nucleic(38) Genomic(3) cDNA(29) Primer pair(3) Other(3)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000006409 (Evidence)
Ensembl Gene Model ENSMUSG00000058756 (Evidence)
Entrez Gene 21833 (Evidence)
NIA Mouse Gene Index U013309
Consensus CDS Project CCDS25362.1
International Mouse Phenotyping Consortium Status Thra
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006409 VEGA Gene Model | MGI Sequence Detail 28369 C57BL/6J ±  kb
transcript OTTMUST00000014597 VEGA | MGI Sequence Detail 2452 Not Applicable 
polypeptide OTTMUSP00000006787 VEGA | MGI Sequence Detail 492 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(8) : SNPs within 2kb(102 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR001723 Steroid hormone receptor
InterPro IPR001728 Thyroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000003428 thyroid hormone receptor alpha
References
(Earliest) J:5152 Pizarro O, et al., A study of recombination between the H-2 (histocompatibility) locus and loci closely linked with it in the house mouse. Transplantation. 1970 Mar;9(3):207-18
(Latest) J:216450 Pessemesse L, et al., p28, a truncated form of TRalpha1 regulates mitochondrial physiology. FEBS Lett. 2014 Nov 3;588(21):4037-43
All references(224)
Other
accession IDs
MGD-MRK-15091, MGD-MRK-15092, MGD-MRK-15093, MGD-MRK-19597, MGD-MRK-9569, MGI:2144519, MGI:2441716

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory