|
Symbol Name ID |
Thra
thyroid hormone receptor alpha MGI:98742 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased T3/T4 ratio |
| Disease(s) Associated with THRA | |
| congenital nongoitrous hypothyroidism 6 |
| Mouse Phenotypes | homeostasis/metabolism phenotype |
increased glucagon secretion |
abnormal insulin secretion |
increased insulin secretion |
impaired adaptive thermogenesis |
increased circulating creatinine level |
increased blood urea nitrogen level |
increased circulating glucose level |
increased circulating glucagon level |
increased circulating insulin level |
decreased circulating insulin-like growth factor I level |
increased circulating leptin level |
increased circulating thyroid-stimulating hormone level |
decreased circulating thyroxine level |
increased circulating thyroxine level |
decreased circulating triiodothyronine level |
increased circulating triiodothyronine level |
increased circulating alkaline phosphatase level |
decreased body temperature |
decreased core body temperature |
increased body temperature |
abnormal glucose homeostasis |
impaired glucose tolerance |
improved glucose tolerance |
increased insulin sensitivity |
insulin resistance |
abnormal thyroid-stimulating hormone level |
increased triiodothyronine level |
abnormal enzyme/coenzyme activity |
impaired lipolysis |
abnormal response/metabolism to endogenous compounds |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||
| Thratm1.1Fcas/Thratm1.1Fcas | ||||||||||||||||||||||||||||||||
| Thratm1Jas/Thratm1Jas | ||||||||||||||||||||||||||||||||
| Thratm1Ven/Thratm1Ven | ||||||||||||||||||||||||||||||||
| Thratm2Jas/Thratm2Jas | ||||||||||||||||||||||||||||||||
| Thratm2Ven/Thratm2Ven | ||||||||||||||||||||||||||||||||
| Thratm3Jas/Thratm3Jas | ||||||||||||||||||||||||||||||||
| Thraem1Ffla/Thra+ | * | |||||||||||||||||||||||||||||||
| Thraem2Ffla/Thra+ | ||||||||||||||||||||||||||||||||
| Thraem3Ffla/Thra+ | * | |||||||||||||||||||||||||||||||
| Thraem4Ffla/Thra+ | * | |||||||||||||||||||||||||||||||
| Thraem5Ffla/Thra+ | * | |||||||||||||||||||||||||||||||
| Thratm1b(EUCOMM)Wtsi/Thra+ | ||||||||||||||||||||||||||||||||
| Thratm1Brnt/Thra+ | ||||||||||||||||||||||||||||||||
| Thratm2Ven/Thra+ | ||||||||||||||||||||||||||||||||
| Thratm4.1Ven/Thra+ | ||||||||||||||||||||||||||||||||
| Thratm1Ffla/Thra+ Tg(Sycp1-cre)4Min/? (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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