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Thbd
Gene Detail
 Symbol
Name
ID
Thbd
thrombomodulin
MGI:98736
Synonyms CD141, TM
Feature Type protein coding gene
Genetic Map
Chromosome 2
73.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr2:148404466-148408188 bp, - strand
From VEGA annotation of GRCm38

  3723 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:308  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog

Protein SuperFamily: thrombomodulin
Gene Tree: Thbd

Human
homologs
Human Homolog THBD, thrombomodulin
NCBI Gene ID 7056
neXtProt AC  NX_P07204
Human Synonyms  AHUS6, BDCA3, CD141, THPH12, THRM, TM
Human Chr (Location)  20p11.2; chr20:23045633-23049664 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human THBD
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous targeted null mutants are growth retarded and die by embryonic day 9.5. Embryos develop further in vitro than in vivo suggesting maternal-fetal incompatibility. Endothelial cell-specific, conditional knockouts suffer fatal juvenile thromboses.
 
Human Diseases Modeled Using Mouse Thbd (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Interactions
Thbd interacts with 249 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process blood coagulation, embryo development, ...
Component cell surface, extracellular space, ...
Function calcium ion binding, transmembrane signaling receptor activity
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (501)    Tissues (95)    Images (62)
Theiler Stages: 11, 13, 15, 17, 19, 20, 21, 22, 23, 28
Assay TypeResults
Immunohistochemistry 15
RNA in situ 474
RT-PCR 12
cDNA source data(44)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(61) Genomic(10) cDNA(46) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000015710 (Evidence)
Ensembl Gene ModelENSMUSG00000074743 (Evidence)
Entrez Gene21824 (Evidence)
UniGene24096
DFCITC1576983
DoTSDT.527579
NIA Mouse Gene IndexU023463
Consensus CDS ProjectCCDS16838.1
International Mouse Knockout Project StatusThbd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015710 VEGA Gene Model | MGI Sequence Detail 3723 C57BL/6J ±  kb
transcript OTTMUST00000037329 VEGA | MGI Sequence Detail 3723 Not Applicable 
polypeptide OTTMUSP00000016721 VEGA | MGI Sequence Detail 577 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(2)
Polymorphisms All PCR and RFLP(5) : PCR(2) RFLP(3) SNPs within 2kb(32 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016316 Complement component C1q/Thrombomodulin
InterPro IPR001304 C-type lectin
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR001491 Thrombomodulin
InterPro IPR015149 Thrombomodulin-like, EGF-like
Protein Ontology PR:000002105 thrombomodulin
References (Earliest) J:196646 Imada M, et al., Fetomodulin: marker surface protein of fetal development which is modulatable by cyclic AMP. Dev Biol. 1987 Aug;122(2):483-91
(Latest) J:203464 Sims-Lucas S, et al., Endothelial Progenitors Exist within the Kidney and Lung Mesenchyme. PLoS One. 2013;8(6):e65993
All references(97)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-15081, MGI:2138918

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory