Thbd
Gene Detail

Symbol Name ID

Thbd thrombomodulin MGI:98736

Synonyms

CD141, TM

Feature Type

protein coding gene

Genetic Map

Chromosome 2

73.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr2:148404466-148408188 bp, - strand From VEGA annotation of GRCm38   3723 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:308  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: thrombomodulin
Gene Tree: Thbd

Human homologs

Human Homolog		THBD, thrombomodulin
NCBI Gene ID		7056
neXtProt AC		NX_P07204
Human Synonyms		AHUS6, BDCA3, CD141, THPH12, THRM, TM
Human Chr (Location)		20p11.2; chr20:23026270-23030301 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human THBD

Alleles and phenotypes

All alleles(11) : Targeted(11)
 

Homozygous targeted null mutants are growth retarded and die by embryonic day 9.5. Embryos develop further in vitro than in vivo suggesting maternal-fetal incompatibility. Endothelial cell-specific, conditional knockouts suffer fatal juvenile thromboses.

 
Human Diseases Modeled Using Mouse Thbd (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	blood coagulation, embryo development, ...
Component	cell surface, extracellular space, ...
Function	calcium ion binding, carbohydrate binding, ...

External Resources: FuncBase

Expression

Literature Summary: (18 records)
Data Summary: Results (490)    Tissues (90)    Images (58)
Theiler Stages: 11, 13, 15, 17, 19, 20, 21, 22, 23, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	474
RT-PCR	12

cDNA source data(43)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(60) Genomic(10) cDNA(45) Primer pair(4) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000015710 (Evidence)
Ensembl Gene Model	ENSMUSG00000074743 (Evidence)
Entrez Gene	21824 (Evidence)
UniGene	24096
DFCI	TC1576983
DoTS	DT.527579
NIA Mouse Gene Index	U023463
Consensus CDS Project	CCDS16838.1
International Mouse Knockout Project Status	Thbd

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015710	VEGA Gene Model | MGI Sequence Detail	3723	C57BL/6J
transcript	OTTMUST00000037329	VEGA | MGI Sequence Detail	3723	Not Applicable
polypeptide	OTTMUSP00000016721	VEGA | MGI Sequence Detail	577	Not Applicable

All sequences(23) RefSeq(2) UniProt(2)

Polymorphisms

All PCR and RFLP(5) : PCR(2) RFLP(3) SNPs(18 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016316	Complement component C1q/Thrombomodulin
InterPro	IPR001304	C-type lectin
InterPro	IPR016187	C-type lectin fold
InterPro	IPR016186	C-type lectin-like
InterPro	IPR001881	EGF-like calcium-binding
InterPro	IPR018097	EGF-like calcium-binding, conserved site
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000152	EGF-type aspartate/asparagine hydroxylation site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR009030	Insulin-like growth factor binding protein, N-terminal
InterPro	IPR001491	Thrombomodulin
InterPro	IPR015149	Thrombomodulin-like, EGF-like
Protein Ontology	PR:000002105	thrombomodulin

References

(Earliest) J:15733 Dittman WA, et al., The structure and function of mouse thrombomodulin. Phorbol myristate acetate stimulates degradation and synthesis of thrombomodulin without affecting mRNA levels in hemangioma cells. J Biol Chem. 1988 Oct 25;263(30):15815-22
(Latest) J:195883 An J, et al., Heparin rescues factor V Leiden-associated placental failure independent of anticoagulation in a murine high-risk pregnancy model. Blood. 2013 Mar 14;121(11):2127-34
All references(91)

Other accession IDs

MGD-MRK-15081, MGI:2138918