About   Help   FAQ
Thbd Gene Detail
Summary
  • Symbol
    Thbd
  • Name
    thrombomodulin
  • Synonyms
    CD141, TM
  • Feature Type
    protein coding gene
  • IDs
    MGI:98736
    NCBI Gene: 21824
  • Gene Overview
    MyGene.info: THBD
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:148404471-148408188 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 73.45 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    32 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98736
protein coding gene Chr2:148404466-148408188 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026607
protein coding gene Chr2:152746703-152750425 (-)
A/J MGP_AJ_G0026571
protein coding gene Chr2:146536461-146540179 (-)
AKR/J MGP_AKRJ_G0026545
protein coding gene Chr2:150768768-150772490 (-)
BALB/cJ MGP_BALBcJ_G0026583
protein coding gene Chr2:146956135-146959857 (-)
C3H/HeJ MGP_C3HHeJ_G0026326
protein coding gene Chr2:151267635-151271357 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027028
protein coding gene Chr2:157191956-157195678 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024406
protein coding gene Chr2:140544197-140547939 (-)
CAST/EiJ MGP_CASTEiJ_G0025787
protein coding gene Chr2:151655169-151658888 (-)
CBA/J MGP_CBAJ_G0026306
protein coding gene Chr2:162958434-162962156 (-)
DBA/2J MGP_DBA2J_G0026440
protein coding gene Chr2:145806034-145809752 (-)
FVB/NJ MGP_FVBNJ_G0026404
protein coding gene Chr2:144302448-144306172 (-)
LP/J MGP_LPJ_G0026544
protein coding gene Chr2:152863834-152867556 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026424
protein coding gene Chr2:167030268-167033986 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027083
protein coding gene Chr2:150774169-150777887 (-)
PWK/PhJ MGP_PWKPhJ_G0025523
protein coding gene Chr2:145488682-145492400 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025324
protein coding gene Chr2:149743757-149747483 (-)
WSB/EiJ MGP_WSBEiJ_G0025861
protein coding gene Chr2:151728721-151732443 (-)



Homology
more
  • Human Ortholog
    THBD, thrombomodulin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    THBD, thrombomodulin
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AHUS6, BDCA3, CD141, THPH12, THRM, TM
  • Links
    NCBI Gene ID: 7056
    neXtProt AC: NX_P07204
    UniProt: P07204

  • Chr Location
    20p11.21; chr20:23045633-23049664 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Thbd mouse models; 2 with human THBD associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    67 phenotypes from 11 alleles in 15 genetic backgrounds
    11 phenotypes from multigenic genotypes
    3 images
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous targeted null mutants are growth retarded and die by embryonic day 9.5. Embryos develop further in vitro than in vivo suggesting maternal-fetal incompatibility. Endothelial cell-specific, conditional knockouts suffer fatal juvenile thromboses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21824 NCBI Gene Model | MGI Sequence Detail 3718 C57BL/6J ±  kb
    transcript NM_009378 RefSeq | MGI Sequence Detail 3718 Not Specified  
    polypeptide P15306 UniProt | EBI | MGI Sequence Detail 577 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 64
      Genomic 10
      cDNA 48
      Primer pair 4
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15081, MGI:2138918
    References
    more
    • Summaries
      All 107
      Developmental Gene Expression 21
      Diseases 1
      Gene Ontology 6
      Phenotypes 46
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:246859 Madhusudhan T, et al., Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function. Blood. 2017 Sep 21;130(12):1445-1455

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory