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Thbd Gene Detail
Summary
  • Symbol
    Thbd
  • Name
    thrombomodulin
  • Synonyms
    CD141, TM
  • Feature Type
    protein coding gene
  • IDs
    MGI:98736
    NCBI Gene: 21824
  • Gene Overview
    MyGene.info: THBD
Location & Maps
more
  • Sequence Map
    Chr2:148404466-148408188 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3723 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 73.45 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    THBD, thrombomodulin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    THBD, thrombomodulin
    Orthology source: HomoloGene
  • Synonyms
    AHUS6, BDCA3, CD141, THPH12, THRM, TM
  • Links
    NCBI Gene ID: 7056
    neXtProt AC: NX_P07204

  • Chr Location
    20p11.2; chr20:23045633-23049664 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Thbd mouse models; 2 with human THBD associations

Human Disease Mouse Models
       Thrombophilia Due to Thrombomodulin Defect; THPH12   OMIM: 614486 View 1 model
       Hemolytic Uremic Syndrome, Atypical, Susceptibility to, 6; AHUS6   OMIM: 612926
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    64 phenotypes from 11 alleles in 15 genetic backgrounds
    11 phenotypes from multigenic genotypes
    3 images
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    12
  • Genomic Mutations
    2 involving Thbd
  • Incidental Mutations
Homozygous targeted null mutants are growth retarded and die by embryonic day 9.5. Embryos develop further in vitro than in vivo suggesting maternal-fetal incompatibility. Endothelial cell-specific, conditional knockouts suffer fatal juvenile thromboses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015710 VEGA Gene Model | MGI Sequence Detail 3723 C57BL/6J ±  kb
transcript OTTMUST00000037329 VEGA | MGI Sequence Detail 3723 Not Applicable  
polypeptide OTTMUSP00000016721 VEGA | MGI Sequence Detail 577 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    32 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 62
    Genomic 10
    cDNA 46
    Primer pair 4
    Other 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-15081, MGI:2138918
References
more
  • Summaries
    All 98
    Developmental Gene Expression 21
    Diseases 1
    Gene Ontology 6
    Phenotypes 43
  • Earliest
    J:196646 Imada M, et al., Fetomodulin: marker surface protein of fetal development which is modulatable by cyclic AMP. Dev Biol. 1987 Aug;122(2):483-91
  • Latest
    J:223253 Roeen Z, et al., Thrombomodulin inhibits the activation of eosinophils and mast cells. Cell Immunol. 2015 Jan;293(1):34-40

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory