Symbol
Name
ID

Thbd
thrombomodulin
MGI:98736

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Elevated circulating C-reactive protein concentration	Elevated erythrocyte sedimentation rate	Joint swelling	Fever
Disease(s) Associated with THBD
rheumatoid arthritis

Mouse Phenotypes

homeostasis/metabolism phenotype

increased myocardial infarct size

abnormal circulating protein level

increased circulating D-dimer level

increased circulating interleukin-1 beta level

decreased circulating interleukin-6 level

increased circulating interleukin-6 level

decreased circulating tumor necrosis factor level

increased circulating tumor necrosis factor level

abnormal blood coagulation

abnormal thrombosis

abnormal lung thrombosis

abnormal placental thrombosis

increased susceptibility to induced thrombosis

abnormal acute phase protein level

hematuria

abnormal enzyme/coenzyme activity

abnormal response to injury

decreased susceptibility to injury

Availability

Mouse Genotype

Thbd^{tm1(THBD)Sltz}/Thbd^{tm1(THBD)Sltz}

Thbd^{tm1.1(THBD)Sltz}/Thbd^{tm1.1(THBD)Sltz}

Thbd^tm1Emc/Thbd^tm1Emc

Thbd^tm1Wlr/Thbd^tm1Wlr

Thbd^tm2.1Emc/Thbd^tm2.1Emc

Thbd^{tm1(THBD)Sltz}/Thbd⁺

Thbd^{tm1.1(THBD)Sltz}/Thbd⁺

Thbd^tm1Wlr/Thbd^tm2Rdr

Thbd^tm1.1Hlwu/Thbd^tm1.1Hlwu
Lyz2^tm1(cre)Ifo/Lyz2⁺ (conditional)

Tg(Tek-cre)1Ywa/0
Thbd^tm2Rdr/Thbd^tm2Wlr (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23