About   Help   FAQ
Tcf7
Gene Detail
 Symbol
Name
ID
Tcf7
transcription factor 7, T cell specific
MGI:98507
Synonyms T cell factor-1, T-cell factor 1, Tcf1, TCF-1
Feature Type protein coding gene
Genetic Map
Chromosome 11
31.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr11:52252371-52283014 bp, - strand
From VEGA annotation of GRCm38

  30644 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2410  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken

Gene Tree: Tcf7

Human
homologs
Human Homolog TCF7, transcription factor 7 (T-cell specific, HMG-box)
NCBI Gene ID 6932
neXtProt AC  NX_P36402
Human Synonyms  TCF-1
Human Chr (Location)  5q31.1; chr5:134114711-134148229 (+)  GRCh38
Alleles
and
phenotypes
All alleles(7) : Targeted(6) Gene trapped(1)
 
Homozygous null mice have defects in T cell development leading to decreased numbers of T cells in the periphery.
 
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process alpha-beta T cell differentiation, brain development, ...
Component nucleus, transcription factor complex
Function beta-catenin binding, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (58 records)
Data Summary: Results (410)    Tissues (357)    Images (41)
Theiler Stages: 2, 3, 4, 5, 11, 15, 16, 17, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 384
Northern blot 1
RT-PCR 25
cDNA source data(80)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(92) Genomic(1) cDNA(83) Primer pair(7) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000005622 (Evidence)
Ensembl Gene ModelENSMUSG00000000782 (Evidence)
Entrez Gene21414 (Evidence)
UniGene31630
DFCITC1581742, TC1631714, TC1683384
DoTSDT.101392463, DT.101392464, DT.101392466, DT.110545852, DT.110545866, DT.492238
NIA Mouse Gene IndexU032752
Consensus CDS ProjectCCDS24670.1
International Mouse Knockout Project StatusTcf7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005622 VEGA Gene Model | MGI Sequence Detail 30644 C57BL/6J ±  kb
transcript OTTMUST00000012509 VEGA | MGI Sequence Detail 1742 Not Applicable 
polypeptide OTTMUSP00000005801 VEGA | MGI Sequence Detail 303 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(24) UniProt(4)
Polymorphisms RFLP(2) : SNPs within 2kb(241 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027397 Catenin binding domain
InterPro IPR013558 CTNNB1 binding, N-teminal
InterPro IPR009071 High mobility group (HMG) box domain
InterPro IPR024940 Transcription factor TCF/LEF
Protein Ontology PR:000016184 transcription factor 7
References (Earliest) J:11147 Oosterwegel M, et al., Cloning of murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-epsilon and T cell receptor alpha enhancers. J Exp Med. 1991 May 1;173(5):1133-42
(Latest) J:206274 Mielke LA, et al., TCF-1 controls ILC2 and NKp46+RORgammat+ innate lymphocyte differentiation and protection in intestinal inflammation. J Immunol. 2013 Oct 15;191(8):4383-91
All references(138)
Other
accession IDs
MGD-MRK-14759, MGI:2144188

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/08/2014
MGI 5.17
The Jackson Laboratory