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Tcf7 Gene Detail
Summary
  • Symbol
    Tcf7
  • Name
    transcription factor 7, T cell specific
  • Synonyms
    T cell factor-1, T-cell factor 1, Tcf1, TCF-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98507
    NCBI Gene: 21414
  • Gene Overview
    MyGene.info: TCF7
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:52252371-52283014 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30644 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 31.86 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    TCF7, transcription factor 7
  • Vertebrate Orthologs
    2
  • Human Ortholog
    TCF7, transcription factor 7
    Orthology source: HGNC
  • Synonyms
    TCF-1
  • Links
    NCBI Gene ID: 6932
    neXtProt AC: NX_P36402
    UniProt: P36402

  • Chr Location
    5q31.1; chr5:134114703-134148229 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 3 alleles in 2 genetic backgrounds
    21 phenotypes from multigenic genotypes
    57 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have defects in T cell development leading to decreased numbers of T cells in the periphery.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005622 VEGA Gene Model | MGI Sequence Detail 30644 C57BL/6J ±  kb
transcript OTTMUST00000012508 VEGA | MGI Sequence Detail 2471 Not Applicable  
polypeptide OTTMUSP00000005800 VEGA | MGI Sequence Detail 303 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    205 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR027397 Catenin binding domain superfamily
    IPR013558 CTNNB1 binding, N-teminal
    IPR009071 High mobility group box domain
    IPR036910 High mobility group box domain superfamily
    IPR028785 Transcription factor 7
    IPR024940 Transcription factor TCF/LEF
Molecular
Reagents
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  • All nucleic 94
    Genomic 1
    cDNA 84
    Primer pair 7
    Other 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-14759, MGI:2144188
References
more
  • Summaries
    All 168
    Developmental Gene Expression 69
    Gene Ontology 9
    Phenotypes 57
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:243411 Rutledge EA, et al., Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development. Development. 2017 Sep 01;144(17):3177-3188

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory