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Tcf7 Gene Detail
Summary
  • Symbol
    Tcf7
  • Name
    transcription factor 7, T cell specific
  • Synonyms
    T cell factor-1, T-cell factor 1, Tcf1, TCF-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98507
    NCBI Gene: 21414
Location & Maps
more
  • Sequence Map
    Chr11:52252371-52283014 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30644 bp   ±  kb flank

  • Genome Browsers
Homology
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Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 3 alleles in 2 genetic backgrounds
    21 phenotypes from multigenic genotypes
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    6
  • Genomic Mutations
    1 involving Tcf7
Homozygous null mice have defects in T cell development leading to decreased numbers of T cells in the periphery.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005622 VEGA Gene Model | MGI Sequence Detail 30644 C57BL/6J ±  kb
transcript OTTMUST00000012508 VEGA | MGI Sequence Detail 2471 Not Applicable  
polypeptide OTTMUSP00000005800 VEGA | MGI Sequence Detail 303 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    241 from dbSNP Build 137
  • RFLP
Protein
Information
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Molecular
Reagents
less
  • All nucleic 93
    Genomic 1
    cDNA 83
    Primer pair 7
    Other 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-14759, MGI:2144188
References
more
  • Summaries
    All 139
    Developmental Gene Expression 62
    Gene Ontology 9
    Phenotypes 46
  • Earliest
    J:11147 Oosterwegel M, et al., Cloning of murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-epsilon and T cell receptor alpha enhancers. J Exp Med. 1991 May 1;173(5):1133-42
  • Latest
    J:222442 Li BI, et al., The orphan GPCR, Gpr161, regulates the retinoic acid and canonical Wnt pathways during neurulation. Dev Biol. 2015 Jun 1;402(1):17-31

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory