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Slc6a6 Gene Detail
Summary
  • Symbol
    Slc6a6
  • Name
    solute carrier family 6 (neurotransmitter transporter, taurine), member 6
  • Synonyms
    Taut
  • Feature Type
    protein coding gene
  • IDs
    MGI:98488
    NCBI Gene: 21366
  • Alliance
  • Transcription Start Sites
    44 TSS
  • Candidate for QTL
    2 QTL
Location &
Maps
more
  • Sequence Map
    Chr6:91661031-91736044 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 6, 40.73 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    260 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98488
protein coding gene Chr6:91661031-91736047 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031050
protein coding gene Chr6:93290842-93369917 (+)
A/J MGP_AJ_G0031019
protein coding gene Chr6:89738364-89813708 (+)
AKR/J MGP_AKRJ_G0030950
protein coding gene Chr6:92226655-92304062 (+)
BALB/cJ MGP_BALBcJ_G0031030
protein coding gene Chr6:89683036-89758173 (+)
C3H/HeJ MGP_C3HHeJ_G0030678
protein coding gene Chr6:92129265-92209715 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031489
protein coding gene Chr6:95711526-95792759 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028656
protein coding gene Chr6:87721464-87797051 (+)
CAST/EiJ MGP_CASTEiJ_G0030137
protein coding gene Chr6:92347942-92429556 (+)
CBA/J MGP_CBAJ_G0030716
protein coding gene Chr6:99270623-99359751 (+)
DBA/2J MGP_DBA2J_G0030869
protein coding gene Chr6:88920651-88997247 (+)
FVB/NJ MGP_FVBNJ_G0030823
protein coding gene Chr6:88130773-88210198 (+)
LP/J MGP_LPJ_G0030949
protein coding gene Chr6:93253248-93333425 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030857
protein coding gene Chr6:103325985-103410695 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031516
protein coding gene Chr6:92069013-92152634 (+)
PWK/PhJ MGP_PWKPhJ_G0029853
protein coding gene Chr6:87875103-87951473 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029682
protein coding gene Chr6:90981116-91062896 (+)
WSB/EiJ MGP_WSBEiJ_G0030221
protein coding gene Chr6:92545004-92629843 (+)



Homology
more
  • Human Ortholog
    SLC6A6, solute carrier family 6 member 6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC6A6, solute carrier family 6 member 6
  • Synonyms
    HTRDC, TAUT
  • Links
    NCBI Gene ID: 6533
    neXtProt AC: NX_P31641
    UniProt: P31641

  • Chr Location
    3p25.1; chr3:14402576-14489349 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with Slc6a6 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 4 alleles in 4 genetic backgrounds
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice have impaired vision associated with retinal degeneration. In addition to the visual defects, mutant mice exhibit reduced female fertility and decreased levels of taurine in a variety of tissues.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21366 NCBI Gene Model | MGI Sequence Detail 75014 C57BL/6J ±  kb
    transcript NM_001410447 RefSeq | MGI Sequence Detail 6249 ZRU/MplStud  
    polypeptide O35316 UniProt | EBI | MGI Sequence Detail 621 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000029748 sodium- and chloride-dependent taurine transporter
    • InterPro Domains
      IPR000175 Sodium:neurotransmitter symporter
      IPR037272 Sodium:neurotransmitter symporter superfamily
      IPR002434 Sodium:neurotransmitter symporter, taurine
    Molecular
    Reagents
    less
    • All nucleic 169
      cDNA 166
      Primer pair 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-14721, MGI:2141371, MGI:2141762
    References
    more
    • Summaries
      All 82
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 12
      Phenotypes 37
    • Earliest
      J:3475 Liu QR, et al., Cloning and expression of a cDNA encoding the transporter of taurine and beta-alanine in mouse brain. Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):12145-9
    • Latest
      J:337205 Singh P, et al., Taurine deficiency as a driver of aging. Science. 2023 Jun 9;380(6649):eabn9257

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory