Slc6a6
Gene Detail

Symbol Name ID

Slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 MGI:98488

Synonyms

Taut

Feature Type

protein coding gene

Genetic Map

Chromosome 6

40.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr6:91684067-91759063 bp, + strand From NCBI annotation of GRCm38   74997 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2291  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Slc6a6

Human homologs

Human Homolog		SLC6A6, solute carrier family 6 (neurotransmitter transporter, taurine), member 6
NCBI Gene ID		6533
neXtProt AC		NX_P31641
Human Synonyms		TAUT
Human Chr (Location)		3p25.1; chr3:14444106-14530857 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(625) : Targeted(2) Gene trapped(623)
 

Homozygous mutant mice have impaired vision associated with retinal degeneration. In addition to the visual defects, mutant mice exhibit reduced female fertility and decreased levels of taurine in a variety of tissues.

 
Human Diseases Modeled Using Mouse Slc6a6 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	amino acid transmembrane transport, beta-alanine transport, ...
Component	integral to membrane, integral to plasma membrane, ...
Function	beta-alanine transmembrane transporter activity, neurotransmitter:sodium symporter activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (271)    Tissues (34)    Images (24)
Theiler Stages: 6, 17, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	262
RT-PCR	9

cDNA source data(163)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(167) cDNA(164) Primer pair(3)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000030096 (Evidence)
Entrez Gene	21366 (Evidence)
UniGene	395650
DFCI	TC1577187, TC1592586, TC1623750, TC1730616
DoTS	DT.101255895, DT.101736105, DT.87072570, DT.91279464
NIA Mouse Gene Index	U007181
Consensus CDS Project	CCDS39570.1
International Mouse Knockout Project Status	Slc6a6

Sequences

Length	Strain/Species
genomic	21366	NCBI Gene Model | MGI Sequence Detail	74997	C57BL/6J
transcript	NM_009320	RefSeq | MGI Sequence Detail	6169	C57BL/6
polypeptide	O35316	UniProt | EBI | MGI Sequence Detail	621	Not Applicable

All sequences(39) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(248 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000175	Sodium:neurotransmitter symporter
InterPro	IPR002434	Sodium:neurotransmitter symporter, taurine
Protein Ontology	PR:000029748	sodium- and chloride-dependent taurine transporter

Graphical View of Protein Domain Structure

References

(Earliest) J:3473 Lane PW, Crimpy (cpy) a new recessive hair mutation on chromosome 15 of the mouse. Mouse Genome. 1992;90(4):682-83
(Latest) J:187781 Kaesler S, et al., Effective T-cell recall responses require the taurine transporter Taut. Eur J Immunol. 2012 Apr;42(4):831-41
All references(56)

Other accession IDs

MGD-MRK-14721, MGI:2141371, MGI:2141762