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Slc6a6 Gene Detail
Summary
  • Symbol
    Slc6a6
  • Name
    solute carrier family 6 (neurotransmitter transporter, taurine), member 6
  • Synonyms
    Taut
  • Feature Type
    protein coding gene
  • IDs
    MGI:98488
    NCBI Gene: 21366
  • Gene Overview
    MyGene.info: SLC6A6
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:91684053-91759066 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      75014 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 40.73 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    SLC6A6, solute carrier family 6 member 6
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SLC6A6, solute carrier family 6 member 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TAUT
  • Links
    NCBI Gene ID: 6533
    neXtProt AC: NX_P31641
    UniProt: P31641

  • Chr Location
    3p25.1; chr3:14402576-14489349 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2291
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SLC6A6
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Slc6a6 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 3 alleles in 3 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice have impaired vision associated with retinal degeneration. In addition to the visual defects, mutant mice exhibit reduced female fertility and decreased levels of taurine in a variety of tissues.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000058000 VEGA Gene Model | MGI Sequence Detail 75014 C57BL/6J ±  kb
    transcript OTTMUST00000142341 VEGA | MGI Sequence Detail 6186 Not Applicable  
    polypeptide OTTMUSP00000074274 VEGA | MGI Sequence Detail 621 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      260 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • InterPro Domains
      IPR000175 Sodium:neurotransmitter symporter
      IPR037272 Sodium:neurotransmitter symporter superfamily
      IPR002434 Sodium:neurotransmitter symporter, taurine
    Molecular
    Reagents
    less
    • All nucleic 169
      cDNA 166
      Primer pair 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-14721, MGI:2141371, MGI:2141762
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 10
      Phenotypes 26
    • Earliest
      J:3475 Liu QR, et al., Cloning and expression of a cDNA encoding the transporter of taurine and beta-alanine in mouse brain. Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):12145-9
    • Latest
      J:247770 Branco RCS, et al., Protein malnutrition blunts the increment of taurine transporter expression by a high-fat diet and impairs taurine reestablishment of insulin secretion. FASEB J. 2017 Sep;31(9):4078-4087

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory