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Slc6a6
Gene Detail
Symbol

Name
ID
Slc6a6
solute carrier family 6 (neurotransmitter transporter, taurine), member 6
MGI:98488
Synonyms
Taut
Feature Type
protein coding gene
Genetic Map
Chromosome 6
40.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr6:91684067-91759063 bp, + strand
From Ensembl annotation of GRCm38

  74997 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2291  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: SLC6A6
Gene Tree: Slc6a6

Human
homologs
SLC6A6, solute carrier family 6 (neurotransmitter transporter), member 6
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6533
neXtProt AC: NX_P31641

Human Synonyms: TAUT

Human Chr (Location): 3p25.1; chr3:14402576-14489349 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(626) : Gene trapped(623) Spontaneous(1) Targeted(2)
Genomic Mutations involving Slc6a6 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutant mice have impaired vision associated with retinal degeneration. In addition to the visual defects, mutant mice exhibit reduced female fertility and decreased levels of taurine in a variety of tissues.
 
Human Diseases Modeled in Mice Using Slc6a6 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Slc6a6 interacts with 403 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Expression
Literature Summary: (4 records)
Data Summary: Results (271)    Tissues (35)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 262
RT-PCR 9
cDNA source data(164)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase slc6a6 ; ZFIN slc6a6b    NEW 
Molecular
reagents
All nucleic(168) cDNA(165) Primer pair(3)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000030096 (Evidence)
Entrez Gene 21366 (Evidence)
UniGene 395650
DFCI TC1577187, TC1592586, TC1623750, TC1730616
DoTS DT.101255895, DT.101736105, DT.87072570, DT.91279464
NIA Mouse Gene Index U007181
Consensus CDS Project CCDS39570.1
International Mouse Phenotyping Consortium Status Slc6a6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030096 Ensembl Gene Model | MGI Sequence Detail 74997 C57BL/6J ±  kb
transcript ENSMUST00000032185 Ensembl | MGI Sequence Detail 6169 Not Applicable 
polypeptide ENSMUSP00000032185 Ensembl | MGI Sequence Detail 621 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(9) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(260 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000175 Sodium:neurotransmitter symporter
InterPro IPR002434 Sodium:neurotransmitter symporter, taurine
Protein Ontology PR:000029748 sodium- and chloride-dependent taurine transporter
References
(Earliest) J:3473 Lane PW, Crimpy (cpy) a new recessive hair mutation on chromosome 15 of the mouse. Mouse Genome. 1992;90(4):682-83
(Latest) J:220765 Ramila KC, et al., Role of protein phosphorylation in excitation-contraction coupling in taurine deficient hearts. Am J Physiol Heart Circ Physiol. 2015 Feb 1;308(3):H232-9
All references(56)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-14721, MGI:2141371, MGI:2141762

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory