Sequence Detail

ID/Version

O35316 Q91WI2 P31642 (UniProt | EBI)

Last sequence update: 2003-11-14
Last annotation update: 2026-06-10

Sequence description from provider

RecName: Full=Sodium- and chloride-dependent taurine transporter;AltName: Full=Solute carrier family 6 member 6;AltName: Full=Taurine transporter {ECO:0000303|PubMed:30270321}; Short=TauT {ECO:0000303|PubMed:30270321};

Provider

SWISS-PROT

Sequence

Polypeptide 621 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Slc6a6	solute carrier family 6 (neurotransmitter transporter, taurine), member 6	75	101	4	510

Sequence references in MGI

J:3475 Liu QR, et al., Cloning and expression of a cDNA encoding the transporter of taurine and beta-alanine in mouse brain. Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):12145-9
J:44210 Vinnakota S, et al., Molecular characterization and in situ localization of a mouse retinal taurine transporter. J Neurochem. 1997 Dec;69(6):2238-50
J:74276 Heller-Stilb B, et al., Disruption of the taurine transporter gene (taut) leads to retinal degeneration in mice. FASEB J. 2002 Feb;16(2):231-3
J:92314 Rascher K, et al., Light deprivation slows but does not prevent the loss of photoreceptors in taurine transporter knockout mice. Vision Res. 2004;44(17):2091-100
J:107911 Warskulat U, et al., Chronic liver disease is triggered by taurine transporter knockout in the mouse. FASEB J. 2006 Mar;20(3):574-6
J:118497 Warskulat U, et al., Taurine transporter knockout depletes muscle taurine levels and results in severe skeletal muscle impairment but leaves cardiac function uncompromised. FASEB J. 2004 Mar;18(3):577-9
J:191581 Zhou Y, et al., Deletion of the gamma-aminobutyric acid transporter 2 (GAT2 and SLC6A13) gene in mice leads to changes in liver and brain taurine contents. J Biol Chem. 2012 Oct 12;287(42):35733-46
J:273853 Qvartskhava N, et al., Taurine transporter (TauT) deficiency impairs ammonia detoxification in mouse liver. Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6313-6318
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:324192 Nishimura T, et al., Hypotaurine Is a Substrate of GABA Transporter Family Members GAT2/Slc6a13 and TAUT/Slc6a6. Biol Pharm Bull. 2018;41(10):1523-1529
J:337205 Singh P, et al., Taurine deficiency as a driver of aging. Science. 2023 Jun 9;380(6649):eabn9257