Tap2
Gene Detail

Symbol Name ID

Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) MGI:98484

Synonyms

Abcb3, Ham2, Ham-2, HAM2, MTP2, PSF2, Tap-2

Feature Type

protein coding gene

Genetic Map

Chromosome 17

17.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr17:34203527-34216321 bp, + strand From VEGA annotation of GRCm38   12795 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37323  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Tap2

Human homologs

Human Homolog		TAP2, transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
NCBI Gene ID		6891
neXtProt AC		NX_Q03519
Human Synonyms		ABC18, ABCB3, APT2, D6S217E, PSF2, PSF-2, RING11
Human Chr (Location)		6p21.3; chr6:32789610-32806547 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TAP2

Alleles and phenotypes

All alleles(2) : Chemically induced(2)
 

Homozygous mutant mice have no CD8+ T cells, although their numbers of CD4+ T cells and B cells are normal.

 

Gene Ontology (GO) classifications

All GO classifications: (62 annotations)

Process	antigen processing and presentation of endogenous peptide antigen via MHC class I, antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent, ...
Component	endoplasmic reticulum, integral to endoplasmic reticulum membrane, ...
Function	ADP binding, ATPase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (106)    Tissues (102)    Images (6)
Theiler Stages: 1, 2, 3, 4, 22, 23

Assay Type	Results
RNA in situ	99
RT-PCR	7

cDNA source data(100)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(107) Genomic(5) cDNA(101) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000026436 (Evidence)
Ensembl Gene Model	ENSMUSG00000024339 (Evidence)
Entrez Gene	21355 (Evidence)
UniGene	14814
DFCI	TC1572995, TC1712224, TC1762298
DoTS	DT.101154604, DT.101389166, DT.526434
NIA Mouse Gene Index	U017849
Consensus CDS Project	CCDS28644.1
International Mouse Knockout Project Status	Tap2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026436	VEGA Gene Model | MGI Sequence Detail	12795	C57BL/6J
transcript	OTTMUST00000065379	VEGA | MGI Sequence Detail	3442	Not Applicable
polypeptide	OTTMUSP00000032581	VEGA | MGI Sequence Detail	702	Not Applicable

All sequences(69) RefSeq(2) UniProt(13)

Polymorphisms

SNPs(178 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003593	AAA+ ATPase domain
InterPro	IPR013306	ABC transporter, B3
InterPro	IPR017871	ABC transporter, conserved site
InterPro	IPR017940	ABC transporter, integral membrane type 1
InterPro	IPR003439	ABC transporter-like
InterPro	IPR001140	ABC transporter, transmembrane domain
InterPro	IPR011527	ABC transporter, transmembrane domain, type 1
InterPro	IPR005293	Antigen peptide transporter 2
Protein Ontology	PR:000016052	antigen peptide transporter 2

References

(Earliest) J:10934 Monaco JJ, et al., Transport protein genes in the murine MHC: possible implications for antigen processing. Science. 1990 Dec 21;250(4988):1723-6
(Latest) J:171252 Huang L, et al., Hydrophobicity as a driver of MHC class I antigen processing. EMBO J. 2011 Apr 20;30(8):1634-44
All references(63)

Other accession IDs

MGD-MRK-10613, MGD-MRK-10615, MGD-MRK-14713, MGD-MRK-14715, MGI:2146874, MGI:3584394