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Tap2
Gene Detail
Symbol

Name
ID
Tap2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
MGI:98484
Synonyms
Abcb3, Ham2, Ham-2, HAM2, MTP2, PSF2, Tap-2
Feature Type
protein coding gene
Genetic Map
Chromosome 17
17.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr17:34203527-34216321 bp, + strand
From VEGA annotation of GRCm38

  12795 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37323  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 2 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: TAP2
Protein SuperFamily: ABC-type transport system, bifunctional permease/ATPase, subfamily B
Gene Tree: Tap2

Human
homologs
TAP2, transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6891
neXtProt AC: NX_Q03519

Human Synonyms: ABC18, ABCB3, APT2, D6S217E, PSF2, PSF-2, RING11

Human Chr (Location): 6p21.3; chr6:32821833-32838823 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TAP2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Chemically induced (ENU)(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice have no CD8+ T cells, although their numbers of CD4+ T cells and B cells are normal.
 
Interactions
Tap2 interacts with 31 markers (Mir33, Mir125b-1, Mir125b-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (103)    Tissues (99)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 99
RT-PCR 4
cDNA source data(100)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100489020    NEW 
Molecular
reagents
All nucleic(107) Genomic(5) cDNA(101) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000026436 (Evidence)
Ensembl Gene Model ENSMUSG00000024339 (Evidence)
Entrez Gene 21355 (Evidence)
UniGene 14814
DFCI TC1572995, TC1712224, TC1762298
DoTS DT.101154604, DT.101389166, DT.526434
NIA Mouse Gene Index U017849
Consensus CDS Project CCDS28644.1
International Mouse Phenotyping Consortium Status Tap2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026436 VEGA Gene Model | MGI Sequence Detail 12795 C57BL/6J ±  kb
transcript OTTMUST00000065379 VEGA | MGI Sequence Detail 3442 Not Applicable 
polypeptide OTTMUSP00000032581 VEGA | MGI Sequence Detail 702 Not Applicable 

For the selected sequences
All sequences(75) RefSeq(6) UniProt(14)
Polymorphisms
SNPs within 2kb(336 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR017871 ABC transporter, conserved site
InterPro IPR003439 ABC transporter-like
InterPro IPR013305 ABC transporter Tap-like
InterPro IPR011527 ABC transporter type 1, transmembrane domain
InterPro IPR005293 Antigen peptide transporter 2
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000016052 antigen peptide transporter 2
References
(Earliest) J:10934 Monaco JJ, et al., Transport protein genes in the murine MHC: possible implications for antigen processing. Science. 1990 Dec 21;250(4988):1723-6
(Latest) J:171252 Huang L, et al., Hydrophobicity as a driver of MHC class I antigen processing. EMBO J. 2011 Apr 20;30(8):1634-44
All references(61)
Other
accession IDs
MGD-MRK-10613, MGD-MRK-10615, MGD-MRK-14713, MGD-MRK-14715, MGI:2146874, MGI:3584394

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory