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Tap2 Gene Detail
Summary
  • Symbol
    Tap2
  • Name
    transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
  • Synonyms
    Abcb3, Ham2, Ham-2, HAM2, MTP2, PSF2, Tap-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98484
    NCBI Gene: 21355
  • Gene Overview
    MyGene.info: TAP2
Location & Maps
more
  • Sequence Map
    Chr17:34203527-34216321 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12795 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    TAP2, transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
  • Vertebrate Orthologs
    11
  • Human Ortholog
    TAP2, transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ABC18, ABCB3, APT2, D6S217E, PSF2, PSF-2, RING11
  • Links
    NCBI Gene ID: 6891
    neXtProt AC: NX_Q03519

  • Chr Location
    6p21.3; chr6:32821833-32838823 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human TAP2 associations

Human Disease Mouse Models
       Bare Lymphocyte Syndrome, Type I   OMIM: 604571
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 3 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Chemically induced (ENU)
    3
  • Incidental Mutations
Homozygous mutant mice have no CD8+ T cells, although their numbers of CD4+ T cells and B cells are normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026436 VEGA Gene Model | MGI Sequence Detail 12795 C57BL/6J ±  kb
transcript OTTMUST00000065379 VEGA | MGI Sequence Detail 3442 Not Applicable  
polypeptide OTTMUSP00000032581 VEGA | MGI Sequence Detail 702 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    4 from dbSNP Build 142
Protein
Information
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  • UniProt
    14 Sequences
  • Protein Ontology
    PR:000016052 antigen peptide transporter 2
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR017871 ABC transporter, conserved site
    IPR003439 ABC transporter-like
    IPR013305 ABC transporter Tap-like
    IPR011527 ABC transporter type 1, transmembrane domain
    IPR005293 Antigen peptide transporter 2
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 107
    Genomic 5
    cDNA 101
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-10613, MGD-MRK-10615, MGD-MRK-14713, MGD-MRK-14715, MGI:2146874, MGI:3584394
References
more
  • Summaries
    All 58
    Developmental Gene Expression 4
    Gene Ontology 10
    Phenotypes 4
  • Earliest
    J:10934 Monaco JJ, et al., Transport protein genes in the murine MHC: possible implications for antigen processing. Science. 1990 Dec 21;250(4988):1723-6
  • Latest
    J:171252 Huang L, et al., Hydrophobicity as a driver of MHC class I antigen processing. EMBO J. 2011 Apr 20;30(8):1634-44

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory