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Tap2
Gene Detail
 Symbol
Name
ID
Tap2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
MGI:98484
Synonyms Abcb3, Ham2, Ham-2, HAM2, MTP2, PSF2, Tap-2
Feature Type protein coding gene
Genetic Map
Chromosome 17
17.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr17:34203527-34216321 bp, + strand
From VEGA annotation of GRCm38

  12795 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37323  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: ABC-type transport system, bifunctional permease/ATPase, subfamily B
Gene Tree: Tap2

Human
homologs
Human Homolog TAP2, transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
NCBI Gene ID 6891
neXtProt AC  NX_Q03519
Human Synonyms  ABC18, ABCB3, APT2, D6S217E, PSF2, PSF-2, RING11
Human Chr (Location)  6p21.3; chr6:32821833-32838770 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TAP2
Alleles
and
phenotypes
All alleles(2) : Chemically induced(2)
 
Homozygous mutant mice have no CD8+ T cells, although their numbers of CD4+ T cells and B cells are normal.
 
Gene Ontology
(GO)
classifications
All GO classifications: (68 annotations)
Process antigen processing and presentation of endogenous peptide antigen via MHC class I, antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent, ...
Component endoplasmic reticulum, extracellular region, ...
Function ADP binding, ATPase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (106)    Tissues (102)    Images (6)
Theiler Stages: 1, 2, 3, 4, 22, 23
Assay TypeResults
RNA in situ 99
RT-PCR 7
cDNA source data(100)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(107) Genomic(5) cDNA(101) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000026436 (Evidence)
Ensembl Gene ModelENSMUSG00000024339 (Evidence)
Entrez Gene21355 (Evidence)
UniGene14814
DFCITC1572995, TC1712224, TC1762298
DoTSDT.101154604, DT.101389166, DT.526434
NIA Mouse Gene IndexU017849
Consensus CDS ProjectCCDS28644.1
International Mouse Knockout Project StatusTap2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026436 VEGA Gene Model | MGI Sequence Detail 12795 C57BL/6J ±  kb
transcript OTTMUST00000065379 VEGA | MGI Sequence Detail 3442 Not Applicable 
polypeptide OTTMUSP00000032581 VEGA | MGI Sequence Detail 702 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(6) UniProt(13)
Polymorphisms SNPs within 2kb(336 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR013306 ABC transporter, B3
InterPro IPR017871 ABC transporter, conserved site
InterPro IPR003439 ABC transporter-like
InterPro IPR001140 ABC transporter, transmembrane domain
InterPro IPR011527 ABC transporter, transmembrane domain, type 1
InterPro IPR005293 Antigen peptide transporter 2
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000016052 antigen peptide transporter 2
References (Earliest) J:10934 Monaco JJ, et al., Transport protein genes in the murine MHC: possible implications for antigen processing. Science. 1990 Dec 21;250(4988):1723-6
(Latest) J:171252 Huang L, et al., Hydrophobicity as a driver of MHC class I antigen processing. EMBO J. 2011 Apr 20;30(8):1634-44
All references(63)
Other
accession IDs
MGD-MRK-10613, MGD-MRK-10615, MGD-MRK-14713, MGD-MRK-14715, MGI:2146874, MGI:3584394

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory