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Tal1
Gene Detail
Symbol

Name
ID
Tal1
T cell acute lymphocytic leukemia 1
MGI:98480
Synonyms
bHLHa17, Hpt, Scl, SCL/tal-1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
52.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(20)
Sequence Map
Chr4:115056426-115071755 bp, + strand
From VEGA annotation of GRCm38

  15330 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2400  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TAL1
Gene Tree: Tal1

Human
homologs
TAL1, T-cell acute lymphocytic leukemia 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6886
neXtProt AC: NX_P17542

Human Synonyms: bHLHa17, SCL, tal-1, TCL5

Human Chr (Location): 1p32; chr1:47216290-47232373 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Spontaneous(1) Targeted(11) Transgenic(1)
Genomic Mutations involving Tal1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous targeted null mutants show retarded growth, edema, lack yolk sac hematopoiesis and die at embryonic day 9.5-10.5. Conditional mutants show loss of megakaryocyte and erhythrocyte progenitors resulting in low hematocrit and platelet count.
 
Human Diseases Modeled in Mice Using Tal1 (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(2)
Interactions
Tal1 interacts with 329 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (87 annotations)
Process angiogenesis, astrocyte fate commitment, ...
Component histone deacetylase complex, Lsd1/2 complex, ...
Function chromatin binding, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (71 records)
Data Summary: Results (445)    Tissues (274)    Images (47)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 77
RNA in situ 212
In situ reporter (knock in) 41
Northern blot 13
RT-PCR 102
cDNA source data(32)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA TAL1 ; Xenbase tal1 ; ZFIN tal1    NEW 
Molecular
reagents
All nucleic(48) Genomic(3) cDNA(32) Primer pair(10) Other(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000008586 (Evidence)
Ensembl Gene Model ENSMUSG00000028717 (Evidence)
Entrez Gene 21349 (Evidence)
UniGene 439685
DFCI TC1709211
DoTS DT.110839250, DT.491806
NIA Mouse Gene Index U004665
Consensus CDS Project CCDS18486.1
International Mouse Phenotyping Consortium Status Tal1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008586 VEGA Gene Model | MGI Sequence Detail 15330 C57BL/6J ±  kb
transcript OTTMUST00000088749 VEGA | MGI Sequence Detail 3703 Not Applicable 
polypeptide OTTMUSP00000048409 VEGA | MGI Sequence Detail 329 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(18) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(55 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000016043 T-cell acute lymphocytic leukemia protein 1
References
(Earliest) J:13897 Lane PW, Hair patches. Mouse News Lett. 1981;65:27
(Latest) J:220476 Walter D, et al., Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells. Nature. 2015 Apr 23;520(7548):549-52
All references(190)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-10924, MGD-MRK-14313, MGD-MRK-14708, MGI:96219

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory