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Tal1
Gene Detail
 Symbol
Name
ID
Tal1
T cell acute lymphocytic leukemia 1
MGI:98480
Synonyms bHLHa17, Hpt, Scl, SCL/tal-1
Feature Type protein coding gene
Genetic Map
Chromosome 4
52.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(20)
Sequence Map
Chr4:115056426-115071755 bp, + strand
From VEGA annotation of GRCm38

  15330 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2400  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Tal1

Human
homologs
Human Homolog TAL1, T-cell acute lymphocytic leukemia 1
NCBI Gene ID 6886
neXtProt AC  NX_P17542
Human Synonyms  bHLHa17, SCL, tal-1, TCL5
Human Chr (Location)  1p32; chr1:47216290-47232266 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Spontaneous(1) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous targeted null mutants show retarded growth, edema, lack yolk sac hematopoiesis and die at embryonic day 9.5-10.5. Conditional mutants show loss of megakaryocyte and erhythrocyte progenitors resulting in low hematocrit and platelet count.
 
Human Diseases Modeled Using Mouse Tal1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Interactions
Tal1 interacts with 330 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (88 annotations)
Process angiogenesis, astrocyte fate commitment, ...
Component histone deacetylase complex, Lsd1/2 complex, ...
Function chromatin binding, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (65 records)
Data Summary: Results (371)    Tissues (211)    Images (45)
Theiler Stages: 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 26, 27, 28
Assay TypeResults
Immunohistochemistry 3
RNA in situ 212
In situ reporter (knock in) 41
Northern blot 13
RT-PCR 102
cDNA source data(31)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(47) Genomic(3) cDNA(31) Primer pair(10) Other(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000008586 (Evidence)
Ensembl Gene ModelENSMUSG00000028717 (Evidence)
Entrez Gene21349 (Evidence)
UniGene439685
DFCITC1709211
DoTSDT.110839250, DT.491806
NIA Mouse Gene IndexU004665
Consensus CDS ProjectCCDS18486.1
International Mouse Knockout Project StatusTal1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008586 VEGA Gene Model | MGI Sequence Detail 15330 C57BL/6J ±  kb
transcript OTTMUST00000088749 VEGA | MGI Sequence Detail 3703 Not Applicable 
polypeptide OTTMUSP00000048409 VEGA | MGI Sequence Detail 329 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(18) UniProt(3)
Polymorphisms RFLP(2) : SNPs within 2kb(55 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000016043 T-cell acute lymphocytic leukemia protein 1
References (Earliest) J:13897 Lane PW, Hair patches. Mouse News Lett. 1981;65:27
(Latest) J:204328 Tondeleir D, et al., Beta-Actin Is Involved in Modulating Erythropoiesis during Development by Fine-Tuning Gata2 Expression Levels. PLoS One. 2013;8(6):e67855
All references(185)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-10924, MGD-MRK-14313, MGD-MRK-14708, MGI:96219

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory