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Tal1 Gene Detail
Summary
  • Symbol
    Tal1
  • Name
    T cell acute lymphocytic leukemia 1
  • Synonyms
    bHLHa17, Hpt, Scl, SCL/tal-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98480
    NCBI Gene: 21349
  • Alliance
  • Transcription Start Sites
    14 TSS
  • Candidate for QTL
    2 QTL
Location &
Maps
more
  • Sequence Map
    Chr4:114913623-114928952 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 4, 52.73 cM
  • Mapping Data
    20 experiments
Strain
Comparison
more
  • SNPs within 2kb
    55 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98480
protein coding gene Chr4:114913623-114928952 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028594
protein coding gene Chr4:115825398-115840634 (+)
A/J MGP_AJ_G0028556
protein coding gene Chr4:111415791-111432255 (+)
AKR/J MGP_AKRJ_G0028504
protein coding gene Chr4:113711179-113727417 (+)
BALB/cJ MGP_BALBcJ_G0028576
protein coding gene Chr4:112043031-112058829 (+)
C3H/HeJ MGP_C3HHeJ_G0028290
protein coding gene Chr4:115330237-115345622 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029020
protein coding gene Chr4:120302245-120320534 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026304
protein coding gene Chr4:105500959-105515901 (+)
CAST/EiJ MGP_CASTEiJ_G0027727
protein coding gene Chr4:112748334-112763575 (+)
CBA/J MGP_CBAJ_G0028258
protein coding gene Chr4:123422631-123440212 (+)
DBA/2J MGP_DBA2J_G0028407
protein coding gene Chr4:112047262-112062577 (+)
FVB/NJ MGP_FVBNJ_G0028375
protein coding gene Chr4:110519714-110534962 (+)
LP/J MGP_LPJ_G0028508
protein coding gene Chr4:116028232-116048182 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028400
protein coding gene Chr4:128563802-128579122 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029056
protein coding gene Chr4:114959631-114974942 (+)
PWK/PhJ MGP_PWKPhJ_G0027452
protein coding gene Chr4:108844162-108859844 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027276
protein coding gene Chr4:111354942-111370168 (+)
WSB/EiJ MGP_WSBEiJ_G0027805
protein coding gene Chr4:114740729-114756068 (+)



Homology
more
  • Human Ortholog
    TAL1, TAL bHLH transcription factor 1, erythroid differentiation factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAL1, TAL bHLH transcription factor 1, erythroid differentiation factor
  • Synonyms
    bHLHa17, SCL, tal-1, TCL5
  • Links
    NCBI Gene ID: 6886
    neXtProt AC: NX_P17542
    UniProt: P17542

  • Chr Location
    1p33; chr1:47216290-47232335 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human TAL1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    74 phenotypes from 9 alleles in 9 genetic backgrounds
    9 phenotypes from multigenic genotypes
    2 images
    73 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous targeted null mutants show retarded growth, edema, lack yolk sac hematopoiesis and die at embryonic day 9.5-10.5. Conditional mutants show loss of megakaryocyte and erhythrocyte progenitors resulting in low hematocrit and platelet count.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21349 NCBI Gene Model | MGI Sequence Detail 15330 C57BL/6J ±  kb
    transcript NM_001425784 RefSeq | MGI Sequence Detail 4649 C57BL/6  
    polypeptide P22091 UniProt | EBI | MGI Sequence Detail 329 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000016043 T-cell acute lymphocytic leukemia protein 1
    • InterPro Domains
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR040238 Helix-loop-helix protein TAL-like
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    Molecular
    Reagents
    less
    • All nucleic 60
      Genomic 3
      cDNA 35
      Primer pair 17
      Other 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10924, MGD-MRK-14313, MGD-MRK-14708, MGI:96219
    References
    more
    • Summaries
      All 255
      Developmental Gene Expression 99
      Diseases 1
      Gene Ontology 46
      Phenotypes 73
    • Earliest
      J:8017 Blackwell JM, et al., Response of BALB/c mice to leishmanial infection. Curr Top Microbiol Immunol. 1985;122:97-106
    • Latest
      J:345248 Tran HN, et al., Dbx1 is a dorsal midbrain-specific determinant of GABAergic neuron fate and regulates differentiation of the dorsal midbrain into the inferior and superior colliculi. Front Cell Dev Biol. 2024;12:1336308

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory