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Tal1 Gene Detail
Summary
  • Symbol
    Tal1
  • Name
    T cell acute lymphocytic leukemia 1
  • Synonyms
    bHLHa17, Hpt, Scl, SCL/tal-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98480
    NCBI Gene: 21349
  • Gene Overview
    MyGene.info: TAL1
Location & Maps
more
  • Sequence Map
    Chr4:115056426-115071755 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15330 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TAL1, T-cell acute lymphocytic leukemia 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TAL1, T-cell acute lymphocytic leukemia 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bHLHa17, SCL, tal-1, TCL5
  • Links
    NCBI Gene ID: 6886
    neXtProt AC: NX_P17542

  • Chr Location
    1p32; chr1:47216290-47232373 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2400
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: TAL1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Tal1 mouse models; 1 with human TAL1 associations

Human Disease Mouse Models
       Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome; HLTRS   OMIM: 137940 View 1 model
       Leukemia, Acute Lymphoblastic; ALL   OMIM: 613065 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    82 phenotypes from 10 alleles in 10 genetic backgrounds
    14 phenotypes from multigenic genotypes
    2 images
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    18
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    11
  • Transgenic
    3
  • Genomic Mutations
    4 involving Tal1
  • Incidental Mutations
Homozygous targeted null mutants show retarded growth, edema, lack yolk sac hematopoiesis and die at embryonic day 9.5-10.5. Conditional mutants show loss of megakaryocyte and erhythrocyte progenitors resulting in low hematocrit and platelet count.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008586 VEGA Gene Model | MGI Sequence Detail 15330 C57BL/6J ±  kb
transcript OTTMUST00000088749 VEGA | MGI Sequence Detail 3703 Not Applicable  
polypeptide OTTMUSP00000048409 VEGA | MGI Sequence Detail 329 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    55 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000016043 T-cell acute lymphocytic leukemia protein 1
  • InterPro Domains
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Molecular
Reagents
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  • All nucleic 48
    Genomic 3
    cDNA 32
    Primer pair 10
    Other 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-10924, MGD-MRK-14313, MGD-MRK-14708, MGI:96219
References
more
  • Summaries
    All 191
    Developmental Gene Expression 74
    Diseases 3
    Gene Ontology 43
    Phenotypes 61
  • Earliest
    J:13897 Lane PW, Hair patches. Mouse News Lett. 1981;65:27
  • Latest
    J:227021 Mallika C, et al., Gbx2 is essential for maintaining thalamic neuron identity and repressing habenular characters in the developing thalamus. Dev Biol. 2015 Nov 1;407(1):26-39

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory