Tal1
Gene Detail

Symbol Name ID

Tal1 T cell acute lymphocytic leukemia 1 MGI:98480

Synonyms

bHLHa17, Hpt, Scl, SCL/tal-1

Feature Type

protein coding gene

Genetic Map

Chromosome 4

52.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(20)

Sequence Map

Chr4:115056426-115071755 bp, + strand From VEGA annotation of GRCm38   15330 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2400  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Tal1

Human homologs

Human Homolog		TAL1, T-cell acute lymphocytic leukemia 1
NCBI Gene ID		6886
neXtProt AC		NX_P17542
Human Synonyms		bHLHa17, SCL, tal-1, TCL5
Human Chr (Location)		1p32; chr1:47681963-47695443 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(10) : Targeted(9) Spontaneous(1)
 

Homozygous targeted null mutants show retarded growth, edema, lack yolk sac hematopoiesis and die at embryonic day 9.5-10.5. Conditional mutants show loss of megakaryocyte and erhythrocyte progenitors resulting in low hematocrit and platelet count.

 
Human Diseases Modeled Using Mouse Tal1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (82 annotations)

Process	angiogenesis, astrocyte fate commitment, ...
Component	histone deacetylase complex, Lsd1/2 complex, ...
Function	chromatin binding, DNA binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (62 records)
Data Summary: Results (326)    Tissues (161)    Images (43)
Theiler Stages: 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 26, 28

Assay Type	Results
Immunohistochemistry	3
RNA in situ	163
In situ reporter (knock in)	41
Northern blot	13
Western blot	4
RT-PCR	102

cDNA source data(31)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(47) Genomic(3) cDNA(31) Primer pair(10) Other(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000008586 (Evidence)
Ensembl Gene Model	ENSMUSG00000028717 (Evidence)
Entrez Gene	21349 (Evidence)
UniGene	439685
DFCI	TC1709211
DoTS	DT.110839250, DT.491806
NIA Mouse Gene Index	U004665
Consensus CDS Project	CCDS18486.1
International Mouse Knockout Project Status	Tal1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000008586	VEGA Gene Model | MGI Sequence Detail	15330	C57BL/6J
transcript	OTTMUST00000088749	VEGA | MGI Sequence Detail	3703	Not Applicable
polypeptide	OTTMUSP00000048409	VEGA | MGI Sequence Detail	329	Not Applicable

All sequences(35) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(2) : SNPs(21 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology	PR:000016043	T-cell acute lymphocytic leukemia protein 1

References

(Earliest) J:13897 Lane PW, Hair patches. Mouse News Lett. 1981;65:27
(Latest) J:192166 Gentile C, et al., VEGF-mediated phosphorylation of eNOS regulates angioblast and embryonic endothelial cell proliferation. Dev Biol. 2013 Jan 1;373(1):163-75
All references(173)

Other accession IDs

MGD-MRK-10924, MGD-MRK-14313, MGD-MRK-14708, MGI:96219