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Syn1
Gene Detail
 Symbol
Name
ID
Syn1
synapsin I
MGI:98460
Synonyms Syn-1, Synapsin Ia, Synapsin Ib
Feature Type protein coding gene
Genetic Map
Chromosome X
16.37 cM, cytoband A1-A4
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
ChrX:20860511-20921004 bp, - strand
From VEGA annotation of GRCm38

  60494 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48483  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Syn1

Human
homologs
Human Homolog SYN1, synapsin I
NCBI Gene ID 6853
neXtProt AC  NX_P17600
Human Synonyms  SYN1a, SYN1b, SYNI
Human Chr (Location)  Xp11.23; chrX:47571901-47619857 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SYN1
Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Gene trapped(17) Targeted(4)
 
Homozygous inactivation of this gene causes impaired CNS synapse formation and synaptic vesicle (SV) clustering, and may lead to altered SV recycling and inhibitory postsynaptic currents, convulsive seizures, increased response to electrical stimulation, and enhanced paired-pulse facilitation.
 
Human Diseases Modeled Using Mouse Syn1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Syn1 interacts with 189 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process neurotransmitter secretion
Component axon, cell, ...
Function calcium-dependent protein binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (36 records)
Data Summary: Results (115)    Tissues (22)    Images (28)
Theiler Stages: 20, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 97
Western blot 12
RT-PCR 2
cDNA source data(30)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(43) Genomic(8) cDNA(33) Primer pair(1) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000017181 (Evidence)
Ensembl Gene ModelENSMUSG00000037217 (Evidence)
Entrez Gene20964 (Evidence)
UniGene439844
Consensus CDS ProjectCCDS53017.1, CCDS53018.1
International Mouse Knockout Project StatusSyn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017181 VEGA Gene Model | MGI Sequence Detail 60494 C57BL/6J ±  kb
transcript OTTMUST00000041608 VEGA | MGI Sequence Detail 3261 Not Applicable 
polypeptide OTTMUSP00000018688 VEGA | MGI Sequence Detail 670 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(4)
Polymorphisms RFLP(4) : SNPs within 2kb(73 from dbSNP Build 137)    SNPs within 2kb including multiple locations(77)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000015870 synapsin-1
References (Earliest) J:8465 Yang-Feng TL, et al., Genes for synapsin I, a neuronal phosphoprotein, map to conserved regions of human and murine X chromosomes. Proc Natl Acad Sci U S A. 1986 Nov;83(22):8679-83
(Latest) J:211346 Verstegen AM, et al., Phosphorylation of synapsin I by cyclin-dependent kinase-5 sets the ratio between the resting and recycling pools of synaptic vesicles at hippocampal synapses. J Neurosci. 2014 May 21;34(21):7266-80
All references(132)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-14680, MGD-MRK-14681

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory