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Syn1 Gene Detail
Summary
  • Symbol
    Syn1
  • Name
    synapsin I
  • Synonyms
    Syn-1, Synapsin Ia, Synapsin Ib
  • Feature Type
    protein coding gene
  • IDs
    MGI:98460
    NCBI Gene: 20964
  • Gene Overview
    MyGene.info: SYN1
  • Alliance
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:20726750-20787157 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 16.37 cM, cytoband A1-A4
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    71 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98460
protein coding gene ChrX:20726750-20787243 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035598
protein coding gene ChrX:15755947-15824223 (-)
A/J MGP_AJ_G0035575
protein coding gene ChrX:15842297-15904033 (-)
AKR/J MGP_AKRJ_G0035508
protein coding gene ChrX:16395048-16457017 (-)
BALB/cJ MGP_BALBcJ_G0035568
protein coding gene ChrX:15610003-15673019 (-)
C3H/HeJ MGP_C3HHeJ_G0035286
protein coding gene ChrX:15979297-16041557 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036104
protein coding gene ChrX:16174460-16243355 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032968
protein coding gene ChrX:14100316-14159631 (-)
CAST/EiJ MGP_CASTEiJ_G0034577
protein coding gene ChrX:15272023-15338477 (-)
CBA/J MGP_CBAJ_G0035255
protein coding gene ChrX:16915149-16982008 (-)
DBA/2J MGP_DBA2J_G0035407
protein coding gene ChrX:15641034-15706557 (-)
FVB/NJ MGP_FVBNJ_G0035353
protein coding gene ChrX:15551677-15614366 (-)
LP/J MGP_LPJ_G0035489
protein coding gene ChrX:16011697-16077197 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035397
protein coding gene ChrX:17173022-17244018 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036111
protein coding gene ChrX:15678409-15741666 (-)
PWK/PhJ MGP_PWKPhJ_G0034278
protein coding gene ChrX:14841895-14906550 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034118
protein coding gene ChrX:15674878-15750708 (-)
WSB/EiJ MGP_WSBEiJ_G0034712
protein coding gene ChrX:15545046-15608745 (-)



Homology
more
  • Human Ortholog
    SYN1, synapsin I
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SYN1, synapsin I
  • Synonyms
    EPILX, MRX50, SYN1a, SYN1b, SYNI
  • Links
    NCBI Gene ID: 6853
    neXtProt AC: NX_P17600
    UniProt: P17600

  • Chr Location
    Xp11.3-p11.23; chrX:47571901-47619857 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Syn1 mouse models; 2 with human SYN1 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 4 alleles in 5 genetic backgrounds
    8 phenotypes from multigenic genotypes
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene causes impaired CNS synapse formation and synaptic vesicle (SV) clustering, and may lead to altered SV recycling and inhibitory postsynaptic currents, convulsive seizures, increased response to electrical stimulation,and enhanced paired-pulse facilitation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20964 NCBI Gene Model | MGI Sequence Detail 60408 C57BL/6J ±  kb
    transcript NM_013680 RefSeq | MGI Sequence Detail 3249 C57BL/6  
    polypeptide O88935 UniProt | EBI | MGI Sequence Detail 706 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      Genomic 8
      cDNA 34
      Primer pair 1
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-14680, MGD-MRK-14681
    References
    more
    • Summaries
      All 183
      Developmental Gene Expression 59
      Diseases 2
      Gene Ontology 25
      Phenotypes 61
    • Earliest
      J:8465 Yang-Feng TL, et al., Genes for synapsin I, a neuronal phosphoprotein, map to conserved regions of human and murine X chromosomes. Proc Natl Acad Sci U S A. 1986 Nov;83(22):8679-83
    • Latest
      J:307970 Jing H, et al., Synapse-specific Lrp4 mRNA enrichment requires Lrp4/MuSK signaling, muscle activity and Wnt non-canonical pathway. Cell Biosci. 2021 Jun 5;11(1):105

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    11/30/2021
    MGI 6.17
    The Jackson Laboratory