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Syn1
Gene Detail
Symbol

Name
ID
Syn1
synapsin I
MGI:98460
Synonyms
Syn-1, Synapsin Ia, Synapsin Ib
Feature Type
protein coding gene
Genetic Map
Chromosome X
16.37 cM, cytoband A1-A4
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
ChrX:20860511-20921004 bp, - strand
From VEGA annotation of GRCm38

  60494 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48483  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SYN1
Gene Tree: Syn1

Human
homologs
SYN1, synapsin I
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6853
neXtProt AC: NX_P17600

Human Synonyms: SYN1a, SYN1b, SYNI

Human Chr (Location): Xp11.23; chrX:47571901-47619857 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SYN1

Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Gene trapped(17) Targeted(4)
Incidental mutations (data from CvDC )
 
Homozygous inactivation of this gene causes impaired CNS synapse formation and synaptic vesicle (SV) clustering, and may lead to altered SV recycling and inhibitory postsynaptic currents, convulsive seizures, increased response to electrical stimulation, and enhanced paired-pulse facilitation.
 
Human Diseases Modeled in Mice Using Syn1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Syn1 interacts with 188 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process neurotransmitter secretion
Component axon, cell, ...
Function calcium-dependent protein binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (38 records)
Data Summary: Results (116)    Tissues (23)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 97
Western blot 13
RT-PCR 2
cDNA source data(30)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase syn1 ; ZFIN syn1    NEW 
Molecular
reagents
All nucleic(43) Genomic(8) cDNA(33) Primer pair(1) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000017181 (Evidence)
Ensembl Gene Model ENSMUSG00000037217 (Evidence)
Entrez Gene 20964 (Evidence)
UniGene 439844
Consensus CDS Project CCDS53017.1, CCDS53018.1
International Mouse Phenotyping Consortium Status Syn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017181 VEGA Gene Model | MGI Sequence Detail 60494 C57BL/6J ±  kb
transcript OTTMUST00000041608 VEGA | MGI Sequence Detail 3261 Not Applicable 
polypeptide OTTMUSP00000018688 VEGA | MGI Sequence Detail 670 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(4)
Polymorphisms
RFLP(4) : SNPs within 2kb(73 from dbSNP Build 137)    SNPs within 2kb including multiple locations(77)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000015870 synapsin-1
References
(Earliest) J:8465 Yang-Feng TL, et al., Genes for synapsin I, a neuronal phosphoprotein, map to conserved regions of human and murine X chromosomes. Proc Natl Acad Sci U S A. 1986 Nov;83(22):8679-83
(Latest) J:216752 Tezuka T, et al., The MuSK activator agrin has a separate role essential for postnatal maintenance of neuromuscular synapses. Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16556-61
All references(136)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-14680, MGD-MRK-14681

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory