Syn1
Gene Detail

Symbol Name ID

Syn1 synapsin I MGI:98460

Synonyms

Syn-1, Synapsin Ia, Synapsin Ib

Feature Type

protein coding gene

Genetic Map

Chromosome X

16.37 cM, cytoband A1-A4
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

ChrX:20860511-20921004 bp, - strand From VEGA annotation of GRCm38   60494 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:48483  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Syn1

Human homologs

Human Homolog		SYN1, synapsin I
NCBI Gene ID		6853
neXtProt AC		NX_P17600
Human Synonyms		SYN1a, SYN1b, SYNI
Human Chr (Location)		Xp11.23; chrX:47431300-47479256 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SYN1

Alleles and phenotypes

All alleles(21) : Targeted(4) Gene trapped(17)
 

Homozygous inactivation of this gene causes impaired CNS synapse formation and synaptic vesicle (SV) clustering, and may lead to altered SV recycling and inhibitory postsynaptic currents, convulsive seizures, increased response to electrical stimulation, and enhanced paired-pulse facilitation.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	neurotransmitter secretion
Component	axon part, cytosol, ...
Function	calcium-dependent protein binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (32 records)
Data Summary: Results (115)    Tissues (22)    Images (28)
Theiler Stages: 20, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	97
Western blot	12
RT-PCR	2

cDNA source data(30)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(43) Genomic(8) cDNA(33) Primer pair(1) Other(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000017181 (Evidence)
Ensembl Gene Model	ENSMUSG00000037217 (Evidence)
Entrez Gene	20964 (Evidence)
UniGene	439844
Consensus CDS Project	CCDS53017.1, CCDS53018.1
International Mouse Knockout Project Status	Syn1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017181	VEGA Gene Model | MGI Sequence Detail	60494	C57BL/6J
transcript	OTTMUST00000041608	VEGA | MGI Sequence Detail	3261	Not Applicable
polypeptide	OTTMUSP00000018688	VEGA | MGI Sequence Detail	670	Not Applicable

All sequences(18) RefSeq(4)

Polymorphisms

RFLP(4) : SNPs(67 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
Protein Ontology	PR:000015870	synapsin-1
Protein Ontology	PR:000025506	synapsin-1 (mouse)

References

(Earliest) J:8465 Yang-Feng TL, et al., Genes for synapsin I, a neuronal phosphoprotein, map to conserved regions of human and murine X chromosomes. Proc Natl Acad Sci U S A. 1986 Nov;83(22):8679-83
(Latest) J:187929 Lin TY, et al., Hispidulin inhibits the release of glutamate in rat cerebrocortical nerve terminals. Toxicol Appl Pharmacol. 2012 Sep 1;263(2):233-43
All references(121)

Other accession IDs

MGD-MRK-14680, MGD-MRK-14681