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Syn1 Gene Detail
Summary
  • Symbol
    Syn1
  • Name
    synapsin I
  • Synonyms
    Syn-1, Synapsin Ia, Synapsin Ib
  • Feature Type
    protein coding gene
  • IDs
    MGI:98460
    NCBI Gene: 20964
  • Gene Overview
    MyGene.info: SYN1
Location & Maps
more
  • Sequence Map
    ChrX:20860511-20921004 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      60494 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 16.37 cM, cytoband A1-A4
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    SYN1, synapsin I
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SYN1, synapsin I
    Orthology source: HomoloGene
  • Synonyms
    SYN1a, SYN1b, SYNI
  • Links
    NCBI Gene ID: 6853
    neXtProt AC: NX_P17600

  • Chr Location
    Xp11.23; chrX:47571901-47619857 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Syn1 mouse models; 1 with human SYN1 associations

Human Disease Mouse Models
       Epilepsy, X-Linked, with Variable Learning Disabilities and Behavior Disorders   OMIM: 300491 View 1 model
       Autism   OMIM: 209850 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 4 alleles in 5 genetic backgrounds
    8 phenotypes from multigenic genotypes
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    21
  • Gene trapped
    17
  • Targeted
    4
  • Incidental Mutations
Homozygous inactivation of this gene causes impaired CNS synapse formation and synaptic vesicle (SV) clustering, and may lead to altered SV recycling and inhibitory postsynaptic currents, convulsive seizures, increased response to electrical stimulation,and enhanced paired-pulse facilitation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017181 VEGA Gene Model | MGI Sequence Detail 60494 C57BL/6J ±  kb
transcript OTTMUST00000041608 VEGA | MGI Sequence Detail 3261 Not Applicable  
polypeptide OTTMUSP00000018688 VEGA | MGI Sequence Detail 670 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    71 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 43
    Genomic 8
    cDNA 33
    Primer pair 1
    Other 1

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-14680, MGD-MRK-14681
References
more
  • Summaries
    All 141
    Developmental Gene Expression 40
    Diseases 2
    Gene Ontology 15
    Phenotypes 52
  • Earliest
    J:8465 Yang-Feng TL, et al., Genes for synapsin I, a neuronal phosphoprotein, map to conserved regions of human and murine X chromosomes. Proc Natl Acad Sci U S A. 1986 Nov;83(22):8679-83
  • Latest
    J:225578 Krishnaswamy A, et al., Sidekick 2 directs formation of a retinal circuit that detects differential motion. Nature. 2015 Aug 27;524(7566):466-70

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory