Syn1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Syn1
synapsin I
MGI:98460

17 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Syn1^tm1Noh/Syn1^tm1Noh involves: 129S4/SvJae	abnormal CNS synapse formation	J:30400
Syn1^tm1Noh/Syn1^tm1Noh involves: 129S4/SvJae	abnormal synaptic vesicle clustering	J:30400
Syn1^tm1Noh/Syn1^tm1Noh involves: 129S4/SvJae * C57BL/6	abnormal inhibitory postsynaptic currents	J:55506
	abnormal synaptic vesicle clustering	J:55506
	abnormal synaptic vesicle recycling	J:55506
Syn1^tm1Pggd/Syn1^tm1Pggd B6.129P2-Syn1^tm1Pggd	abnormal emotion/affect behavior	J:201707
	abnormal social investigation	J:201707
	impaired social transmission of food preference	J:201707
	increased aggression towards mice	J:201707
	normal taste/olfaction phenotype	J:201707
Syn1^tm1Pggd/Syn1^tm1Pggd involves: 129	abnormal excitatory postsynaptic potential	J:29086
	abnormal hippocampus pyramidal cell morphology	J:29085
	abnormal neurotransmitter secretion	J:29086
	abnormal seizure response to electrical stimulation	J:29086
	abnormal synaptic vesicle clustering	J:29086
	delayed CNS synapse formation	J:29085
	increased synaptic depression	J:29086
Syn1^tm1Sud/Syn1^tm1Sud involves: 129S7/SvEvBrd	convulsive seizures	J:15701
Syn1^tm1Sud/Syn1^tm1Sud involves: 129S7/SvEvBrd	enhanced paired-pulse facilitation	J:15701
Syn1^tm2Noh/Syn1^tm2Noh involves: 129S4/SvJae	abnormal CNS synapse formation	J:30400
Syn1^tm2Noh/Syn1^tm2Noh involves: 129S4/SvJae	abnormal synaptic vesicle clustering	J:30400

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23