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Med22 Gene Detail
Summary
  • Symbol
    Med22
  • Name
    mediator complex subunit 22
  • Synonyms
    Surf5, Surf-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:98446
    NCBI Gene: 20933
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:26795279-26800654 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 19.09 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    25 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98446
protein coding gene Chr2:26795274-26800689 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025498
protein coding gene Chr2:24876905-24882320 (-)
A/J MGP_AJ_G0025475
protein coding gene Chr2:23932794-23938209 (-)
AKR/J MGP_AKRJ_G0025445
protein coding gene Chr2:24711937-24717352 (-)
BALB/cJ MGP_BALBcJ_G0025471
protein coding gene Chr2:24048894-24054309 (-)
C3H/HeJ MGP_C3HHeJ_G0025232
protein coding gene Chr2:24651180-24656595 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025915
protein coding gene Chr2:25710018-25715433 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023326
protein coding gene Chr2:22771221-22777127 (-)
CAST/EiJ MGP_CASTEiJ_G0024695
protein coding gene Chr2:24529174-24534596 (-)
CBA/J MGP_CBAJ_G0025210
protein coding gene Chr2:26605641-26611056 (-)
DBA/2J MGP_DBA2J_G0025343
protein coding gene Chr2:23746788-23752203 (-)
FVB/NJ MGP_FVBNJ_G0025305
protein coding gene Chr2:23504513-23509928 (-)
LP/J MGP_LPJ_G0025429
protein coding gene Chr2:24821064-24826479 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025336
protein coding gene Chr2:26669616-26675031 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025974
protein coding gene Chr2:24654706-24660121 (-)
PWK/PhJ MGP_PWKPhJ_G0024443
protein coding gene Chr2:23542255-23547788 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024243
protein coding gene Chr2:24806857-24812515 (-)
WSB/EiJ MGP_WSBEiJ_G0024764
protein coding gene Chr2:24772081-24777496 (-)



Homology
more
  • Human Ortholog
    MED22, mediator complex subunit 22
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MED22, mediator complex subunit 22
  • Synonyms
    MED24, SRB6, surf-5, SURF5
  • Links
    NCBI Gene ID: 6837
    neXtProt AC: NX_Q15528
    UniProt: Q15528

  • Chr Location
    9q34.2; chr9:133338312-133348131 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 3 alleles in 3 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete preweaning lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20933 NCBI Gene Model | MGI Sequence Detail 5376 C57BL/6J ±  kb
    transcript NM_011513 RefSeq | MGI Sequence Detail 3466 Not Specified  
    polypeptide Q62276 UniProt | EBI | MGI Sequence Detail 200 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000010294 mediator of RNA polymerase II transcription subunit 22
    • PDB
    • InterPro Domains
      IPR009332 Mediator of RNA polymerase II transcription subunit 22
    Molecular
    Reagents
    less
    • All nucleic 106
      Genomic 1
      cDNA 104
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14649, MGD-MRK-14654, MGI:2139329, MGI:2139404
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 7
    • Earliest
      J:10274 Huxley C, et al., The mouse surfeit locus contains a cluster of six genes associated with four CpG-rich islands in 32 kilobases of genomic DNA. Mol Cell Biol. 1990 Feb;10(2):605-14
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory