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Med22 Gene Detail
Summary
  • Symbol
    Med22
  • Name
    mediator complex subunit 22
  • Synonyms
    Surf5, Surf-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:98446
    NCBI Gene: 20933
  • Gene Overview
    MyGene.info: MED22
Location & Maps
more
  • Sequence Map
    Chr2:26905262-26910677 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5416 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 19.09 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    MED22, mediator complex subunit 22
  • Vertebrate Orthologs
    11
  • Human Ortholog
    MED22, mediator complex subunit 22
    Orthology source: HomoloGene
  • Synonyms
    MED24, surf-5, SURF5
  • Links
    NCBI Gene ID: 6837
    neXtProt AC: NX_Q15528

  • Chr Location
    9q34.2; chr9:133340901-133348156 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4913
    1 human;1 mouse;2 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: MED22
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    2
  • Targeted
    2
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011738 VEGA Gene Model | MGI Sequence Detail 5416 C57BL/6J ±  kb
transcript OTTMUST00000027510 VEGA | MGI Sequence Detail 973 Not Applicable  
polypeptide OTTMUSP00000012503 VEGA | MGI Sequence Detail 200 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    25 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR009332 Mediator of RNA polymerase II transcription subunit 22
Molecular
Reagents
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  • All nucleic 105
    Genomic 1
    cDNA 103
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-14649, MGD-MRK-14654, MGI:2139329, MGI:2139404
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:10274 Huxley C, et al., The mouse surfeit locus contains a cluster of six genes associated with four CpG-rich islands in 32 kilobases of genomic DNA. Mol Cell Biol. 1990 Feb;10(2):605-14
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory