Med22 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Med22
mediator complex subunit 22
MGI:98446

17 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Med22^{tm1a(EUCOMM)Hmgu}/Med22⁺ Th^tm1(cre)Te/Th⁺ involves: 129X1/SvJ * C57BL/6N	normal renal/urinary system phenotype	J:300239
Med22^{tm1a(EUCOMM)Hmgu}/Med22^{tm1a(EUCOMM)Hmgu} Th^tm1(cre)Te/Th⁺ involves: 129X1/SvJ * C57BL/6N	preweaning lethality, complete penetrance	J:300239
Med22^{tm1a(EUCOMM)Wtsi}/Med22^{tm1a(EUCOMM)Wtsi} C57BL/6N-Med22^{tm1a(EUCOMM)Wtsi}/Wtsi	preweaning lethality, complete penetrance	J:211773
Med22^{tm1c(EUCOMM)Hmgu}/Med22^{tm1c(EUCOMM)Hmgu} Tg(Nphs1-cre)#Seq/0 involves: 129S4/SvJaeSor * C57BL/6J * C57BL/6N	abnormal renal glomerulus morphology	J:300239
	albuminuria	J:300239
	decreased podocyte number	J:300239
	dilated renal tubule	J:300239
	glomerulosclerosis	J:300239
	increased blood urea nitrogen level	J:300239
	increased podocyte apoptosis	J:300239
	increased susceptibility to injury	J:300239
	kidney failure	J:300239
	podocyte foot process effacement	J:300239
	podocyte vacuoles	J:300239
	premature death	J:300239
	renal cast	J:300239
	renal interstitial fibrosis	J:300239
	renal tubule atrophy	J:300239

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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