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Il1rl1
Gene Detail
Symbol

Name
ID
Il1rl1
interleukin 1 receptor-like 1
MGI:98427
STS
Synonyms
DER4, Fit-1, Ly84, St2, ST2, ST2L, St2-rs1, T1, T1 gene, T1/ST2
Feature Type
protein coding gene
Genetic Map
Chromosome 1
19.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:40429570-40465415 bp, + strand
From VEGA annotation of GRCm38

  35846 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2862  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: IL1RL1
Protein SuperFamily: interleukin-1 receptor type I
Gene Tree: Il1rl1

Human
homologs
IL1RL1, interleukin 1 receptor-like 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9173
neXtProt AC: NX_Q01638

Human Synonyms: DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1

Human Chr (Location): 2q12; chr2:102311502-102352366 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display an abnormal Th2 type inflammatory response.
 
Interactions
Il1rl1 interacts with 304 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (135)    Tissues (53)    Images (43)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 34
Northern blot 13
RT-PCR 22
RNase protection 60
cDNA source data(56)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN il1rl1    NEW 
Molecular
reagents
All nucleic(61) Genomic(3) cDNA(56) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000037806 (Evidence)
Ensembl Gene Model ENSMUSG00000026069 (Evidence)
Entrez Gene 17082 (Evidence)
UniGene 289824
DFCI TC1579281, TC1601736
DoTS DT.101365331, DT.101723639, DT.55100927
NIA Mouse Gene Index U042155
Consensus CDS Project CCDS35548.1, CCDS56626.1
International Mouse Phenotyping Consortium Status Il1rl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037806 VEGA Gene Model | MGI Sequence Detail 35846 C57BL/6J ±  kb
transcript OTTMUST00000097562 VEGA | MGI Sequence Detail 5302 Not Applicable 
polypeptide OTTMUSP00000054731 VEGA | MGI Sequence Detail 567 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(12) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(349 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR015621 Interleukin-1 receptor family
InterPro IPR004074 Interleukin-1 receptor, type I/II
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
Protein Ontology PR:000008994 interleukin-1 receptor-like 1
References
(Earliest) J:9936 Klemenz R, et al., Serum- and oncoprotein-mediated induction of a gene with sequence similarity to the gene encoding carcinoembryonic antigen. Proc Natl Acad Sci U S A. 1989 Aug;86(15):5708-12
(Latest) J:222580 Reichenbach DK, et al., The IL-33/ST2 axis augments effector T-cell responses during acute GVHD. Blood. 2015 May 14;125(20):3183-92
All references(119)
Other
accession IDs
MGD-MRK-14615, MGD-MRK-16618, MGI:99831

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory