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Il1rl1
Gene Detail
 Symbol
Name
ID
Il1rl1
interleukin 1 receptor-like 1
MGI:98427
STS D1Mit122
Synonyms DER4, Fit-1, Ly84, St2, ST2, ST2L, St2-rs1, T1, T1 gene, T1/ST2
Feature Type protein coding gene
Genetic Map
Chromosome 1
19.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:40429570-40465415 bp, + strand
From VEGA annotation of GRCm38

  35846 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2862  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: interleukin-1 receptor type I
Gene Tree: Il1rl1

Human
homologs
Human Homolog IL1RL1, interleukin 1 receptor-like 1
NCBI Gene ID 9173
neXtProt AC  NX_Q01638
Human Synonyms  DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1
Human Chr (Location)  2q12; chr2:102311502-102352332 (+)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display an abnormal Th2 type inflammatory response.
 
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process interleukin-33-mediated signaling pathway, negative regulation of cell proliferation, ...
Component cell surface, external side of plasma membrane, ...
Function interleukin-1 receptor activity, interleukin-33 binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (87)    Tissues (33)    Images (23)
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 24, 28
Assay TypeResults
RNA in situ 23
RNase protection 64
cDNA source data(52)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(55) Genomic(3) cDNA(52)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000037806 (Evidence)
Ensembl Gene ModelENSMUSG00000026069 (Evidence)
Entrez Gene17082 (Evidence)
UniGene289824
DFCITC1579281, TC1601736
DoTSDT.101365331, DT.101723639, DT.55100927
NIA Mouse Gene IndexU042155
Consensus CDS ProjectCCDS35548.1, CCDS56626.1
International Mouse Knockout Project StatusIl1rl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037806 VEGA Gene Model | MGI Sequence Detail 35846 C57BL/6J ±  kb
transcript OTTMUST00000097562 VEGA | MGI Sequence Detail 5302 Not Applicable 
polypeptide OTTMUSP00000054731 VEGA | MGI Sequence Detail 567 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(12) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(349 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR015621 Interleukin-1 receptor family
InterPro IPR004074 Interleukin-1 receptor, type I/II
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
Protein Ontology PR:000008994 interleukin-1 receptor-like 1
References (Earliest) J:9936 Klemenz R, et al., Serum- and oncoprotein-mediated induction of a gene with sequence similarity to the gene encoding carcinoembryonic antigen. Proc Natl Acad Sci U S A. 1989 Aug;86(15):5708-12
(Latest) J:210323 Van Dyken SJ, et al., Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and gammadelta T cells. Immunity. 2014 Mar 20;40(3):414-24
All references(110)
Other
accession IDs
MGD-MRK-14615, MGD-MRK-16618, MGI:99831

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory