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Serpina3m Gene Detail
Summary
  • Symbol
    Serpina3m
  • Name
    serine (or cysteine) peptidase inhibitor, clade A, member 3M
  • Synonyms
    3e46, alpha-1 antiproteinase, antitrypsin, contrapsin-like, MMCM7, MMSPi2.4, Spi2.4, Spi-2l, Spi-2rs1, Spi2-rs1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98378
    NCBI Gene: 20717
  • Gene Overview
    MyGene.info: SERPINA3
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:104387157-104394259 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 54.12 cM, cytoband F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    235 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98378
protein coding gene Chr12:104338486-104394259 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020075
protein coding gene Chr12:106178147-106185239 (+)
A/J MGP_AJ_G0020029
protein coding gene Chr12:102100750-102154957 (+)
AKR/J MGP_AKRJ_G0020006
protein coding gene Chr12:105011319-105100443 (+)
BALB/cJ MGP_BALBcJ_G0020015
protein coding gene Chr12:102481456-102565546 (+)
C3H/HeJ MGP_C3HHeJ_G0019818
protein coding gene Chr12:105556891-105563984 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020461
protein coding gene Chr12:109439002-109496795 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018074
protein coding gene Chr12:98860602-98867373 (+)
CAST/EiJ MGP_CASTEiJ_G0019354
protein coding gene Chr12:100038276-100043570 (-)
CBA/J MGP_CBAJ_G0019785
protein coding gene Chr12:113587962-113698740 (+)
DBA/2J MGP_DBA2J_G0019902
protein coding gene Chr12:101608994-101697943 (+)
FVB/NJ MGP_FVBNJ_G0019887
protein coding gene Chr12:100472834-100479345 (+)
LP/J MGP_LPJ_G0019977
protein coding gene Chr12:105959395-106053357 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019925
protein coding gene Chr12:117175034-117180057 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020490
protein coding gene Chr12:104473474-104531444 (+)
PWK/PhJ MGP_PWKPhJ_G0019121
protein coding gene Chr12:96152107-96206855 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018924
protein coding gene Chr12:98779539-98784396 (+)
WSB/EiJ MGP_WSBEiJ_G0019418
protein coding gene Chr12:105404335-105496033 (+)



Homology
more
  • Human Ortholog
    SERPINA3, serpin family A member 3
  • Vertebrate Orthologs
    15
  • Human Ortholog
    SERPINA3, serpin family A member 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AACT, ACT, GIG24, GIG25
  • Links
    NCBI Gene ID: 12
    neXtProt AC: NX_P01011
    UniProt: P01011

  • Chr Location
    14q32.13; chr14:94612377-94624053 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20717 NCBI Gene Model | MGI Sequence Detail 7103 C57BL/6J ±  kb
transcript NM_009253 RefSeq | MGI Sequence Detail 1668 C57BL/6  
polypeptide Q03734 UniProt | EBI | MGI Sequence Detail 418 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-14522, MGD-MRK-14524, MGD-MRK-14527, MGI:2144772
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 3
  • Earliest
    J:11249 Ohkubo K, et al., Cloning, structure and expression of cDNA for mouse contrapsin and a related protein. Biochem J. 1991 Jun 1;276(Pt 2):337-42
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory