About   Help   FAQ
Sox5 Gene Detail
Summary
  • Symbol
    Sox5
  • Name
    SRY (sex determining region Y)-box 5
  • Synonyms
    A730017D01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:98367
    NCBI Gene: 20678
  • Gene Overview
    MyGene.info: SOX5
Location & Maps
more
  • Sequence Map
    Chr6:143828425-144781977 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      953553 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 76.14 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    SOX5, SRY-box 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SOX5, SRY-box 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LAMSHF, L-SOX5, L-SOX5B, L-SOX5F
  • Links
    NCBI Gene ID: 6660
    neXtProt AC: NX_P35711

  • Chr Location
    12p12.1; chr12:23529495-24562669 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 5 alleles in 5 genetic backgrounds
    24 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Gene trapped
    5
  • Targeted
    5
  • Transposon induced
    1
  • Incidental Mutations
Homozygous null mice fail to breathe and die at birth exhibiting a narrow thoracic cage, irregularly mineralized sternum, cleft secondary palate, and delayed bone mineralization. Homozygotes for a transposon induced insertion die shortly after birth exhibiting cyanosis and respiratory distress.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025246 VEGA Gene Model | MGI Sequence Detail 953553 C57BL/6J ±  kb
transcript OTTMUST00000062143 VEGA | MGI Sequence Detail 7243 Not Applicable  
polypeptide OTTMUSP00000030591 VEGA | MGI Sequence Detail 763 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    10822 from dbSNP Build 142
Protein
Information
less
  • UniProt
    11 Sequences
  • Protein Ontology
    PR:000015431 transcription factor SOX-5
  • PDB
  • InterPro Domains
    IPR009071 High mobility group box domain
Molecular
Reagents
less
  • All nucleic 55
    cDNA 43
    Primer pair 11
    Other 1

    Microarray probesets 8
Other
Accession IDs
less
MGD-MRK-14506, MGI:2141442, MGI:2442476
References
more
  • Summaries
    All 117
    Developmental Gene Expression 69
    Gene Ontology 9
    Phenotypes 19
  • Earliest
    J:1195 Denny P, et al., A conserved family of genes related to the testis determining gene, SRY. Nucleic Acids Res. 1992 Jun 11;20(11):2887
  • Latest
    J:230652 Harb K, et al., Area-specific development of distinct projection neuron subclasses is regulated by postnatal epigenetic modifications. Elife. 2016;5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/24/2016
MGI 6.04
The Jackson Laboratory