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Sox5 Gene Detail
Summary
  • Symbol
    Sox5
  • Name
    SRY (sex determining region Y)-box 5
  • Synonyms
    A730017D01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:98367
    NCBI Gene: 20678
  • Gene Overview
    MyGene.info: SOX5
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:143828425-144781977 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      953553 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 76.14 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    SOX5, SRY-box 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SOX5, SRY-box 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LAMSHF, L-SOX5, L-SOX5B, L-SOX5F
  • Links
    NCBI Gene ID: 6660
    neXtProt AC: NX_P35711
    UniProt: P35711

  • Chr Location
    12p12.1; chr12:23529499-24562701 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 5 alleles in 5 genetic backgrounds
    24 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice fail to breathe and die at birth exhibiting a narrow thoracic cage, irregularly mineralized sternum, cleft secondary palate, and delayed bone mineralization. Homozygotes for a transposon induced insertion die shortly after birth exhibiting cyanosis and respiratory distress.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000025246 VEGA Gene Model | MGI Sequence Detail 953553 C57BL/6J ±  kb
    transcript OTTMUST00000062143 VEGA | MGI Sequence Detail 7243 Not Applicable  
    polypeptide OTTMUSP00000030591 VEGA | MGI Sequence Detail 763 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      10822 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • PDB
    • InterPro Domains
      IPR009071 High mobility group box domain
      IPR036910 High mobility group box domain superfamily
    Molecular
    Reagents
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    • All nucleic 57
      cDNA 43
      Primer pair 12
      Other 2

      Microarray probesets 8
    Other
    Accession IDs
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    MGD-MRK-14506, MGI:2141442, MGI:2442476
    References
    more
    • Summaries
      All 140
      Developmental Gene Expression 84
      Gene Ontology 9
      Phenotypes 20
    • Earliest
      J:1195 Denny P, et al., A conserved family of genes related to the testis determining gene, SRY. Nucleic Acids Res. 1992 Jun 11;20(11):2887
    • Latest
      J:245768 Landry-Truchon K, et al., HOXA5 plays tissue-specific roles in the developing respiratory system. Development. 2017 Oct 01;144(19):3547-3561

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory