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Sox5
Gene Detail
 Symbol
Name
ID
Sox5
SRY (sex determining region Y)-box 5
MGI:98367
Synonyms A730017D01Rik
Feature Type protein coding gene
Genetic Map
Chromosome 6
76.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:143828425-144781977 bp, - strand
From VEGA annotation of GRCm38

  953553 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21378  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription factor Sox5/Sox6/Sox13
Gene Tree: Sox5

Human
homologs
Human Homolog SOX5, SRY (sex determining region Y)-box 5
NCBI Gene ID 6660
neXtProt AC  NX_P35711
Human Synonyms  L-SOX5, L-SOX5B, L-SOX5F
Human Chr (Location)  12p12.1; chr12:23532297-24562449 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(5) Targeted(5) Transposon induced(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice fail to breathe and die at birth exhibiting a narrow thoracic cage, irregularly mineralized sternum, cleft secondary palate, and delayed bone mineralization. Homozygotes for a transposon induced insertion die shortly after birth exhibiting cyanosis and respiratory distress.
 
Interactions
Sox5 interacts with 475 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process cartilage development, cell fate commitment, ...
Component nuclear transcription factor complex, nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (59 records)
Data Summary: Results (272)    Tissues (250)    Images (27)
Theiler Stages: 2, 3, 4, 5, 13, 17, 18, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 191
In situ reporter (knock in) 6
Northern blot 6
RT-PCR 69
cDNA source data(42)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(55) cDNA(43) Primer pair(11) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000025246 (Evidence)
Ensembl Gene ModelENSMUSG00000041540 (Evidence)
Entrez Gene20678 (Evidence)
UniGene1752
DFCITC1584353, TC1591084, TC1595061, TC1598155, TC1611481, TC1618788, TC1622628, TC1663286
DoTSDT.110498636, DT.40167928, DT.87056835, DT.87058469, DT.87068737, DT.91338328, DT.91387566, DT.91573194, DT.94140408, DT.94192670, DT.94238186, DT.97388485
PDB1I11
Consensus CDS ProjectCCDS39702.1, CCDS51954.2, CCDS57469.1
International Mouse Knockout Project StatusSox5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025246 VEGA Gene Model | MGI Sequence Detail 953553 C57BL/6J ±  kb
transcript OTTMUST00000062143 VEGA | MGI Sequence Detail 7243 Not Applicable 
polypeptide OTTMUSP00000030591 VEGA | MGI Sequence Detail 763 Not Applicable 

For the selected sequences
All sequences(173) RefSeq(78) UniProt(12)
Polymorphisms SNPs within 2kb(10895 from dbSNP Build 137)    SNPs within 2kb including multiple locations(10897)
Protein-related
information
ResourceIDDescription
InterPro IPR009071 High mobility group (HMG) box domain
Protein Ontology PR:000015431 transcription factor SOX-5
References (Earliest) J:1195 Denny P, et al., A conserved family of genes related to the testis determining gene, SRY. Nucleic Acids Res. 1992 Jun 11;20(11):2887
(Latest) J:197151 Cloetta D, et al., Inactivation of mTORC1 in the developing brain causes microcephaly and affects gliogenesis. J Neurosci. 2013 May 1;33(18):7799-810
All references(110)
Other
accession IDs
MGD-MRK-14506, MGI:2141442, MGI:2442476

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory