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Sox5
Gene Detail
Symbol

Name
ID
Sox5
SRY (sex determining region Y)-box 5
MGI:98367
Synonyms
A730017D01Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 6
76.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:143828425-144781977 bp, - strand
From VEGA annotation of GRCm38

  953553 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21378  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription factor Sox5/Sox6/Sox13
Gene Tree: Sox5

Human
homologs
Human Homolog SOX5, SRY (sex determining region Y)-box 5
NCBI Gene ID 6660
neXtProt AC  NX_P35711
Human Synonyms  L-SOX5, L-SOX5B, L-SOX5F
Human Chr (Location)  12p12.1; chr12:23532297-24562449 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(5) Targeted(5) Transposon induced(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice fail to breathe and die at birth exhibiting a narrow thoracic cage, irregularly mineralized sternum, cleft secondary palate, and delayed bone mineralization. Homozygotes for a transposon induced insertion die shortly after birth exhibiting cyanosis and respiratory distress.
 
Interactions
Sox5 interacts with 475 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process cartilage development, cell fate commitment, ...
Component nuclear transcription factor complex, nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (59 records)
Data Summary: Results (272)    Tissues (250)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 191
In situ reporter (knock in) 6
Northern blot 6
RT-PCR 69
cDNA source data(42)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(55) cDNA(43) Primer pair(11) Other(1)
Microarray probesets(8)
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025246 VEGA Gene Model | MGI Sequence Detail 953553 C57BL/6J ±  kb
transcript OTTMUST00000062143 VEGA | MGI Sequence Detail 7243 Not Applicable 
polypeptide OTTMUSP00000030591 VEGA | MGI Sequence Detail 763 Not Applicable 

For the selected sequences
All sequences(173) RefSeq(78) UniProt(12)
Polymorphisms
SNPs within 2kb(10895 from dbSNP Build 137)    SNPs within 2kb including multiple locations(10897)
Protein-related
information
ResourceIDDescription
InterPro IPR009071 High mobility group (HMG) box domain
Protein Ontology PR:000015431 transcription factor SOX-5
References
(Earliest) J:1195 Denny P, et al., A conserved family of genes related to the testis determining gene, SRY. Nucleic Acids Res. 1992 Jun 11;20(11):2887
(Latest) J:197151 Cloetta D, et al., Inactivation of mTORC1 in the developing brain causes microcephaly and affects gliogenesis. J Neurosci. 2013 May 1;33(18):7799-810
All references(110)
Other
accession IDs
MGD-MRK-14506, MGI:2141442, MGI:2442476

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory