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Sox4 Gene Detail
Summary
  • Symbol
    Sox4
  • Name
    SRY (sex determining region Y)-box 4
  • Synonyms
    Sox-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:98366
    NCBI Gene: 20677
  • Gene Overview
    MyGene.info: SOX4
  • Alliance
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:28950716-28953682 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 12.87 cM, cytoband A3-A5
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98366
protein coding gene Chr13:28948919-28953713 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020409
protein coding gene Chr13:26740309-26745100 (-)
A/J MGP_AJ_G0020364
protein coding gene Chr13:26123967-26128747 (-)
AKR/J MGP_AKRJ_G0020341
protein coding gene Chr13:26621392-26626186 (-)
BALB/cJ MGP_BALBcJ_G0020359
protein coding gene Chr13:26179782-26184576 (-)
C3H/HeJ MGP_C3HHeJ_G0020162
protein coding gene Chr13:26664785-26669566 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020795
protein coding gene Chr13:27689320-27694102 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018386
protein coding gene Chr13:24536891-24541697 (-)
CAST/EiJ MGP_CASTEiJ_G0019679
protein coding gene Chr13:26306436-26311223 (-)
CBA/J MGP_CBAJ_G0020118
protein coding gene Chr13:28882337-28887130 (-)
DBA/2J MGP_DBA2J_G0020240
protein coding gene Chr13:25636797-25641591 (-)
FVB/NJ MGP_FVBNJ_G0020225
protein coding gene Chr13:25243343-25248135 (-)
LP/J MGP_LPJ_G0020317
protein coding gene Chr13:27011650-27016462 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020251
protein coding gene Chr13:29080736-29085530 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020836
protein coding gene Chr13:26292305-26297099 (-)
PWK/PhJ MGP_PWKPhJ_G0019434
protein coding gene Chr13:25768938-25773729 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019255
protein coding gene Chr13:25187003-25191797 (-)
WSB/EiJ MGP_WSBEiJ_G0019741
protein coding gene Chr13:26550453-26555245 (-)



Homology
more
  • Human Ortholog
    SOX4, SRY-box transcription factor 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SOX4, SRY-box transcription factor 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CSS10, EVI16
  • Links
    NCBI Gene ID: 6659
    neXtProt AC: NX_Q06945
    UniProt: Q06945

  • Chr Location
    6p22.3; chr6:21593741-21598619 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 6 alleles in 9 genetic backgrounds
    87 phenotypes from multigenic genotypes
    1 images
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous targeted null mutants die at embryonic day 14 due to circulatory failure and showing impaired development of the semilunar valves and the muscular ventricular septum. Null fetal liver cells are unable to develop into B-cells in chimeric mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20677 NCBI Gene Model | MGI Sequence Detail 2967 C57BL/6J ±  kb
    transcript NM_009238 RefSeq | MGI Sequence Detail 4808 C57BL/6  
    polypeptide Q06831 UniProt | EBI | MGI Sequence Detail 440 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 2
      cDNA 23
      Primer pair 7
      Other 3

      Microarray probesets 13
    Other
    Accession IDs
    less
    MGD-MRK-14495, MGD-MRK-14505, MGI:2145172
    References
    more
    • Summaries
      All 161
      Developmental Gene Expression 85
      Gene Ontology 20
      Phenotypes 46
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:273632 Planells B, et al., Differential isoform expression and alternative splicing in sex determination in mice. BMC Genomics. 2019 Mar 12;20(1):202

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    10/15/2019
    MGI 6.14
    The Jackson Laboratory