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Sox4
Gene Detail
Symbol

Name
ID
Sox4
SRY (sex determining region Y)-box 4
MGI:98366
Synonyms
Sox-4
Feature Type
protein coding gene
Genetic Map
Chromosome 13
12.87 cM, cytoband A3-A5
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr13:28948919-28953713 bp, - strand
From VEGA annotation of GRCm38

  4795 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2338  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: SOX4
Protein SuperFamily: SOX-12/11/4a protein
Gene Tree: Sox4

Human
homologs
SOX4, SRY (sex determining region Y)-box 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6659
neXtProt AC: NX_Q06945

Human Synonyms: EVI16

Human Chr (Location): 6p22.3; chr6:21593741-21598619 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(2) Gene trapped(1) Radiation induced(1) Targeted(4)
Genomic Mutations involving Sox4 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous targeted null mutants die at embryonic day 14 due to circulatory failure and showing impaired development of the semilunar valves and the muscular ventricular septum. Null fetal liver cells are unable to develop into B-cells in chimeric mice.
 
Phenotype Images(1)
Interactions
Sox4 interacts with 346 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (71 annotations)
Process ascending aorta morphogenesis, atrial septum primum morphogenesis, ...
Component cell, cytoplasm, ...
Function core promoter sequence-specific DNA binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (57 records)
Data Summary: Results (496)    Tissues (292)    Images (77)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 387
Northern blot 7
Western blot 3
RT-PCR 99
cDNA source data(17)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase sox4 ; ZFIN sox4a, sox4b    NEW 
Molecular
reagents
All nucleic(30) Genomic(2) cDNA(21) Primer pair(7)
Microarray probesets(13)
Other database
links
VEGA Gene Model OTTMUSG00000000729 (Evidence)
Ensembl Gene Model ENSMUSG00000076431 (Evidence)
Entrez Gene 20677 (Evidence)
DFCI TC1574054, TC1600227, TC1602852, TC1673772
DoTS DT.101295449, DT.101324550, DT.496867, DT.94391997, DT.97393119
NIA Mouse Gene Index U072950
PDB 3U2B
Consensus CDS Project CCDS26411.1
International Mouse Phenotyping Consortium Status Sox4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000729 VEGA Gene Model | MGI Sequence Detail 4795 C57BL/6J ±  kb
transcript OTTMUST00000001373 VEGA | MGI Sequence Detail 4795 Not Applicable 
polypeptide OTTMUSP00000000649 VEGA | MGI Sequence Detail 440 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(6 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009071 High mobility group box domain
Protein Ontology PR:000015430 transcription factor SOX-4
References
(Earliest) J:10645 Gubbay J, et al., A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes [see comments]. Nature. 1990 Jul 19;346(6281):245-50
(Latest) J:220744 Xu EE, et al., SOX4 cooperates with neurogenin 3 to regulate endocrine pancreas formation in mouse models. Diabetologia. 2015 May;58(5):1013-23
All references(119)
Other
accession IDs
MGD-MRK-14495, MGD-MRK-14505, MGI:2145172

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory