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Sox4 Gene Detail
Summary
  • Symbol
    Sox4
  • Name
    SRY (sex determining region Y)-box 4
  • Synonyms
    Sox-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:98366
    NCBI Gene: 20677
  • Gene Overview
    MyGene.info: SOX4
Location & Maps
more
  • Sequence Map
    Chr13:28948919-28953713 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4795 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 12.87 cM, cytoband A3-A5
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    SOX4, SRY-box 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SOX4, SRY-box 4
    Orthology source: HomoloGene
  • Synonyms
    EVI16
  • Links
    NCBI Gene ID: 6659
    neXtProt AC: NX_Q06945

  • Chr Location
    6p22.3; chr6:21593741-21598619 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 6 alleles in 9 genetic backgrounds
    87 phenotypes from multigenic genotypes
    1 images
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (ENU)
    2
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Sox4
  • Incidental Mutations
Homozygous targeted null mutants die at embryonic day 14 due to circulatory failure and showing impaired development of the semilunar valves and the muscular ventricular septum. Null fetal liver cells are unable to develop into B-cells in chimeric mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000729 VEGA Gene Model | MGI Sequence Detail 4795 C57BL/6J ±  kb
transcript OTTMUST00000001373 VEGA | MGI Sequence Detail 4795 Not Applicable  
polypeptide OTTMUSP00000000649 VEGA | MGI Sequence Detail 440 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    6 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000015430 transcription factor SOX-4
  • PDB
  • InterPro Domains
    IPR009071 High mobility group box domain
Molecular
Reagents
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  • All nucleic 30
    Genomic 2
    cDNA 21
    Primer pair 7

    Microarray probesets 13
Other
Accession IDs
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MGD-MRK-14495, MGD-MRK-14505, MGI:2145172
References
more
  • Summaries
    All 128
    Developmental Gene Expression 68
    Gene Ontology 18
    Phenotypes 37
  • Earliest
    J:10645 Gubbay J, et al., A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes [see comments]. Nature. 1990 Jul 19;346(6281):245-50
  • Latest
    J:231303 Cordi S, et al., Role of beta-catenin in development of bile ducts. Differentiation. 2016 Jan-Mar;91(1-3):42-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory