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Sox12 Gene Detail
Summary
  • Symbol
    Sox12
  • Name
    SRY (sex determining region Y)-box 12
  • Synonyms
    2010205A02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:98360
    NCBI Gene: 20667
  • Gene Overview
    MyGene.info: SOX12
Location & Maps
more
  • Sequence Map
    Chr2:152393611-152398063 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4453 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SOX12, SRY-box 12
  • Vertebrate Orthologs
    6
  • Human Ortholog
    SOX12, SRY-box 12
    Orthology source: HomoloGene
  • Synonyms
    SOX22
  • Links
    NCBI Gene ID: 6666
    neXtProt AC: NX_O15370

  • Chr Location
    20p13; chr20:325571-330228 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotypes from multigenic genotypes
    10 phenotype references
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Sox12
Mice homozygous for a null allele exhibit no phenotypic abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015843 VEGA Gene Model | MGI Sequence Detail 4453 C57BL/6J ±  kb
transcript OTTMUST00000116819 VEGA | MGI Sequence Detail 4453 Not Applicable  
polypeptide OTTMUSP00000065190 VEGA | MGI Sequence Detail 314 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    18 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000015420 transcription factor SOX-12
  • InterPro Domains
    IPR009071 High mobility group box domain
    IPR031267 Transcription factor SOX-12
Molecular
Reagents
less
  • All nucleic 62
    cDNA 60
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-14499, MGI:1917235
References
more
  • Summaries
    All 44
    Developmental Gene Expression 15
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:4011 Wright EM, et al., Seven new members of the Sox gene family expressed during mouse development. Nucleic Acids Res. 1993 Feb 11;21(3):744
  • Latest
    J:227261 Gnedeva K, et al., SoxC transcription factors are essential for the development of the inner ear. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):14066-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory