Gene Expression Literature Summary

• Symbol: Sox12
• Name: SRY (sex determining region Y)-box 12
• ID: MGI:98360

27 matching records from 27 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E9.5	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16.5	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)					1						1	1			1		1	1
In situ RNA (section)	1	3		4		5	1	6		8	2	3	1	1		7	1	3
In situ RNA (whole mount)												1
Northern blot						2												1
RT-PCR		2	1	2	1	5		5	1	4	1	2	3	1		2		4
cDNA clones					1				1	1								1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Sox12  SRY (sex determining region Y)-box 12   (Synonyms: 2010205A02Rik)
Results	Reference
5	J:223863 Bhattaram P, Penzo-Mendez A, Kato K, Bandyopadhyay K, Gadi A, Taketo MM, Lefebvre V, SOXC proteins amplify canonical WNT signaling to secure nonchondrocytic fates in skeletogenesis. J Cell Biol. 2014 Dec 8;207(5):657-71
2	J:175338 Bhattaram P, Penzo-Mendez A, Sock E, Colmenares C, Kaneko KJ, Vassilev A, Depamphilis ML, Wegner M, Lefebvre V, Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors. Nat Commun. 2010;1:9
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
9	J:173070 Dy P, Penzo-Mendez A, Wang H, Pedraza CE, Macklin WB, Lefebvre V, The three SoxC proteins--Sox4, Sox11 and Sox12--exhibit overlapping expression patterns and molecular properties. Nucleic Acids Res. 2008 May;36(9):3101-17
1	J:266021 Foronda M, Martinez P, Schoeftner S, Gomez-Lopez G, Schneider R, Flores JM, Pisano DG, Blasco MA, Sox4 links tumor suppression to accelerated aging in mice by modulating stem cell activation. Cell Rep. 2014 Jul 24;8(2):487-500
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1*	J:231595 Gurdziel K, Vogt KR, Walton KD, Schneider GK, Gumucio DL, Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Dev Dyn. 2016 May;245(5):614-26
8	J:137911 Hoser M, Potzner MR, Koch JM, Bosl MR, Wegner M, Sock E, Sox12 deletion in the mouse reveals nonreciprocal redundancy with the related Sox4 and Sox11 transcription factors. Mol Cell Biol. 2008 Aug;28(15):4675-87
3	J:232434 Huang H, Yang X, Bao M, Cao H, Miao X, Zhang X, Gan L, Qiu M, Zhang Z, Ablation of the Sox11 Gene Results in Clefting of the Secondary Palate Resembling the Pierre Robin Sequence. J Biol Chem. 2016 Mar 25;291(13):7107-18
9*	J:198192 Huang J, Arsenault M, Kann M, Lopez-Mendez C, Saleh M, Wadowska D, Taglienti M, Ho J, Miao Y, Sims D, Spears J, Lopez A, Wright G, Hartwig S, The transcription factor Sry-related HMG box-4 (SOX4) is required for normal renal development in vivo. Dev Dyn. 2013 Jun;242(6):790-9
1	J:306163 Ji S, Yang Z, Gozali L, Kenney T, Kocabas A, Jinsook Park C, Hynes M, Distinct expression of select and transcriptome-wide isolated 3'UTRs suggests critical roles in development and transition states. PLoS One. 2021;16(5):e0250669
1	J:226965 Kato K, Bhattaram P, Penzo-Mendez A, Gadi A, Lefebvre V, SOXC Transcription Factors Induce Cartilage Growth Plate Formation in Mouse Embryos by Promoting Noncanonical WNT Signaling. J Bone Miner Res. 2015 Sep;30(9):1560-71
5*	J:229536 Kawasaki K, Kawasaki M, Watanabe M, Idrus E, Nagai T, Oommen S, Maeda T, Hagiwara N, Que J, Sharpe PT, Ohazama A, Expression of Sox genes in tooth development. Int J Dev Biol. 2015;59(10-12):471-8
5	J:240528 Kocabas A, Duarte T, Kumar S, Hynes MA, Widespread Differential Expression of Coding Region and 3' UTR Sequences in Neurons and Other Tissues. Neuron. 2015 Dec 16;88(6):1149-56
5	J:256120 Kuwajima T, Soares CA, Sitko AA, Lefebvre V, Mason C, SoxC Transcription Factors Promote Contralateral Retinal Ganglion Cell Differentiation and Axon Guidance in the Mouse Visual System. Neuron. 2017 Mar 8;93(5):1110-1125.e5
3*	J:84446 Lioubinski O, Muller M, Wegner M, Sander M, Expression of Sox transcription factors in the developing mouse pancreas. Dev Dyn. 2003 Jul;227(3):402-8
1	J:316050 Paul MH, Harvey RP, Wegner M, Sock E, Cardiac outflow tract development relies on the complex function of Sox4 and Sox11 in multiple cell types. Cell Mol Life Sci. 2014 Aug;71(15):2931-45
2	J:273632 Planells B, Gomez-Redondo I, Pericuesta E, Lonergan P, Gutierrez-Adan A, Differential isoform expression and alternative splicing in sex determination in mice. BMC Genomics. 2019 Mar 12;20(1):202
1	J:148018 Sagai T, Amano T, Tamura M, Mizushina Y, Sumiyama K, Shiroishi T, A cluster of three long-range enhancers directs regional Shh expression in the epithelial linings. Development. 2009 May;136(10):1665-74
1	J:186632 Shim S, Kwan KY, Li M, Lefebvre V, Sestan N, Cis-regulatory control of corticospinal system development and evolution. Nature. 2012 Jun 7;486(7401):74-9
1	J:36018 Stock DW, Buchanan AV, Zhao Z, Weiss KM, Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth. Genomics. 1996 Oct 15;37(2):234-7
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
5	J:107647 Thuret S, Bhatt L, O'Leary DD, Simon HH, Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta. Mol Cell Neurosci. 2004 Mar;25(3):394-405
3*	J:235366 Watanabe M, Kawasaki K, Kawasaki M, Portaveetus T, Oommen S, Blackburn J, Nagai T, Kitamura A, Nishikawa A, Kodama Y, Takagi R, Maeda T, Sharpe PT, Ohazama A, Spatio-temporal expression of Sox genes in murine palatogenesis. Gene Expr Patterns. 2016 Jul;21(2):111-8
7*	J:104307 Wilson ME, Yang KY, Kalousova A, Lau J, Kosaka Y, Lynn FC, Wang J, Mrejen C, Episkopou V, Clevers HC, German MS, The HMG Box Transcription Factor Sox4 Contributes to the Development of the Endocrine Pancreas. Diabetes. 2005 Dec;54(12):3402-9
2	J:220744 Xu EE, Krentz NA, Tan S, Chow SZ, Tang M, Nian C, Lynn FC, SOX4 cooperates with neurogenin 3 to regulate endocrine pancreas formation in mouse models. Diabetologia. 2015 May;58(5):1013-23
6*	J:240405 Zhao L, Arsenault M, Ng ET, Longmuss E, Chau TC, Hartwig S, Koopman P, SOX4 regulates gonad morphogenesis and promotes male germ cell differentiation in mice. Dev Biol. 2017 Mar 01;423(1):46-56