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Sox11
Gene Detail
Symbol

Name
ID
Sox11
SRY (sex determining region Y)-box 11
MGI:98359
Synonyms
1110038H03Rik, 6230403H02Rik, end1
Feature Type
protein coding gene
Genetic Map
Chromosome 12
9.95 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:27334264-27342574 bp, - strand
From VEGA annotation of GRCm38

  8311 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37733  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SOX11
Protein SuperFamily: SOX-12/11/4a protein
Gene Tree: Sox11

Human
homologs
SOX11, SRY (sex determining region Y)-box 11
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 6664
neXtProt AC: NX_P35716

Human Synonyms: MRD27

Human Chr (Location): 2p25; chr2:5692667-5701385 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SOX11

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display neonatal lethality with impaired ossification and impaired development of the heart, lung, spleen, stomach, skeleton and pancreas. Mice homozygous for a different knock-out allele exhibit abnormal nervous system development and complete neonatal lethality.
 
Phenotype Images(1)
Interactions
Sox11 interacts with 263 markers (Mir7-1, Mir10a, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (81 annotations)
Process cardiac ventricle formation, cell differentiation, ...
Component cytoplasm, nucleus
Function DNA binding, enhancer sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (60 records)
Data Summary: Results (369)    Tissues (281)    Images (54)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 240
Northern blot 2
RT-PCR 127
cDNA source data(28)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA SOX11 ; Xenbase sox11 ; ZFIN sox11a, sox11b    NEW 
Molecular
reagents
All nucleic(40) cDNA(32) Primer pair(8)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000021163 (Evidence)
Ensembl Gene Model ENSMUSG00000063632 (Evidence)
Entrez Gene 20666 (Evidence)
DFCI TC1579106, TC1586225, TC1596797, TC1604073, TC1639944, TC1650282, TC1665342, TC1777221
DoTS DT.103571478, DT.525047, DT.529295, DT.94260399, DT.99841910
NIA Mouse Gene Index U070418, U367574
Consensus CDS Project CCDS25849.1
International Mouse Phenotyping Consortium Status Sox11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021163 VEGA Gene Model | MGI Sequence Detail 8311 C57BL/6J ±  kb
transcript OTTMUST00000050139 VEGA | MGI Sequence Detail 8311 Not Applicable 
polypeptide OTTMUSP00000023364 VEGA | MGI Sequence Detail 395 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(62 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009071 High mobility group (HMG) box domain
Protein Ontology PR:000015419 transcription factor SOX-11
References
(Earliest) J:4011 Wright EM, et al., Seven new members of the Sox gene family expressed during mouse development. Nucleic Acids Res. 1993 Feb 11;21(3):744
(Latest) J:220744 Xu EE, et al., SOX4 cooperates with neurogenin 3 to regulate endocrine pancreas formation in mouse models. Diabetologia. 2015 May;58(5):1013-23
All references(103)
Other
accession IDs
MGD-MRK-14498, MGI:1913439, MGI:1915029, MGI:2144888

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory