Sox11 MGI Mouse Gene Detail - MGI:98359 - SRY (sex determining region Y)-box 11

Sox11 Gene Detail

Symbol

Sox11
Name

SRY (sex determining region Y)-box 11
Synonyms

1110038H03Rik, 6230403H02Rik, end1

Feature Type

protein coding gene
IDs

MGI:98359
NCBI Gene: 20666
Gene Overview

MyGene.info: SOX11

Sequence Map

Chr12:27334264-27342574 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

8311 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 9.95 cM, cytoband A3
Mapping Data

3 experiments

Human Ortholog

SOX11, SRY-box 11

Vertebrate Orthologs

8

Human Ortholog

SOX11, SRY-box 11
Orthology source: HomoloGene, HGNC
Synonyms

MRD27
Links

HGNC:11191

NCBI Gene ID: 6664

neXtProt AC: NX_P35716
Chr Location

2p25; chr2:5692667-5701385 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 37733
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: SOX11
Protein SuperFamily

SOX-12/11/4a protein
Gene Tree

Sox11

Diseases

1 with human SOX11 associations

				Human Disease	Mouse Models
				Mental Retardation, Autosomal Dominant 27; MRD27 OMIM: 615866

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

76 phenotypes from 6 alleles in 7 genetic backgrounds
70 phenotypes from multigenic genotypes
1 images
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Targeted

7
Incidental Mutations

Mutagenetix , APF

Homozygous null mice display neonatal lethality with impaired ossification and impaired development of the heart, lung, spleen, stomach, skeleton and pancreas. Mice homozygous for a different knock-out allele exhibit abnormal nervous system development and complete neonatal lethality.

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All GO Annotations

78
GO References

15

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

472
Tissues

364
cDNA Data

30
Literature Summary

68

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO
Other Vertebrate Links

GEISHA SOX11

Xenbase sox11

ZFIN sox11a, sox11b

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Sox11 interacts with 263 markers (Mir7-1, Mir10a, Mir17, ...) View All

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All Sequences

37
RefSeq

2
UniProt

2
CCDS

CCDS25849.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000021163	VEGA Gene Model \| MGI Sequence Detail	8311	C57BL/6J	± kb
transcript	OTTMUST00000050139	VEGA \| MGI Sequence Detail	8311	Not Applicable
polypeptide	OTTMUSP00000023364	VEGA \| MGI Sequence Detail	395	Not Applicable

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SNPs within 2kb

61 from dbSNP Build 142

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UniProt

2 Sequences
Protein Ontology

PR:000015419 transcription factor SOX-11
InterPro Domains

IPR009071 High mobility group box domain

IPR029551 Transcription factor SOX-11

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All nucleic 43

cDNA 34

Primer pair 8

Other 1

Microarray probesets 8

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MGD-MRK-14498, MGI:1913439, MGI:1915029, MGI:2144888

Summaries

All 108

Developmental Gene Expression 68

Gene Ontology 15

Phenotypes 21
Earliest

J:4011 Wright EM, et al., Seven new members of the Sox gene family expressed during mouse development. Nucleic Acids Res. 1993 Feb 11;21(3):744
Latest

J:232434 Huang H, et al., Ablation of the Sox11 Gene Results in Clefting of the Secondary Palate Resembling the Pierre Robin Sequence. J Biol Chem. 2016 Mar 25;291(13):7107-18

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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