Sox11
Gene Detail

Symbol Name ID

Sox11 SRY-box containing gene 11 MGI:98359

Synonyms

1110038H03Rik, 6230403H02Rik, end1

Feature Type

protein coding gene

Genetic Map

Chromosome 12

9.95 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr12:27334264-27342574 bp, - strand From VEGA annotation of GRCm38   8311 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37733  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 chicken; 2 zebrafish

Protein SuperFamily: SOX-12/11/4a protein
Gene Tree: Sox11

Human homologs

Human Homolog		SOX11, SRY (sex determining region Y)-box 11
NCBI Gene ID		6664
neXtProt AC		NX_P35716
Human Chr (Location)		2p25; chr2:5832799-5841517 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygous null mice display neonatal lethality with impaired ossification and impaired development of the heart, lung, spleen, stomach, skeleton, and pancreas.

 

Gene Ontology (GO) classifications

All GO classifications: (79 annotations)

Process	cardiac ventricle formation, cell differentiation, ...
Component	cytoplasm, nucleus
Function	DNA binding, enhancer sequence-specific DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (49 records)
Data Summary: Results (344)    Tissues (263)    Images (54)
Theiler Stages: 2, 3, 11, 15, 16, 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	239
Northern blot	2
RT-PCR	103

cDNA source data(28)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(39) cDNA(32) Primer pair(7)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000021163 (Evidence)
Ensembl Gene Model	ENSMUSG00000063632 (Evidence)
Entrez Gene	20666 (Evidence)
DFCI	TC1579106, TC1586225, TC1596797, TC1604073, TC1639944, TC1650282, TC1665342, TC1777221
DoTS	DT.103571478, DT.525047, DT.529295, DT.94260399, DT.99841910
NIA Mouse Gene Index	U070418, U367574
Consensus CDS Project	CCDS25849.1
International Mouse Knockout Project Status	Sox11

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021163	VEGA Gene Model | MGI Sequence Detail	8311	C57BL/6J
transcript	OTTMUST00000050139	VEGA | MGI Sequence Detail	8311	Not Applicable
polypeptide	OTTMUSP00000023364	VEGA | MGI Sequence Detail	395	Not Applicable

All sequences(52) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(34 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009071	High mobility group, superfamily
InterPro	IPR017386	SOX-12/11/4a
Protein Ontology	PR:000015419	transcription factor SOX-11

References

(Earliest) J:4011 Wright EM, et al., Seven new members of the Sox gene family expressed during mouse development. Nucleic Acids Res. 1993 Feb 11;21(3):744
(Latest) J:194066 Usui A, et al., The early retinal progenitor-expressed gene Sox11 regulates the timing of the differentiation of retinal cells. Development. 2013 Feb;140(4):740-50
All references(92)

Other accession IDs

MGD-MRK-14498, MGI:1913439, MGI:1915029, MGI:2144888