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Sox11 Gene Detail
Summary
  • Symbol
    Sox11
  • Name
    SRY (sex determining region Y)-box 11
  • Synonyms
    1110038H03Rik, 6230403H02Rik, end1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98359
    NCBI Gene: 20666
  • Gene Overview
    MyGene.info: SOX11
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr12:27334264-27342574 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      8311 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 9.95 cM, cytoband A3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SOX11, SRY-box 11
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SOX11, SRY-box 11
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MRD27
  • Links
    NCBI Gene ID: 6664
    neXtProt AC: NX_P35716
    UniProt: P35716

  • Chr Location
    2p25.2; chr2:5692667-5701385 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Sox11 mouse models; 1 with human SOX11 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    85 phenotypes from 6 alleles in 8 genetic backgrounds
    70 phenotypes from multigenic genotypes
    5 images
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display neonatal lethality with impaired ossification and impaired development of the heart, lung, spleen, stomach, skeleton and pancreas. Mice homozygous for a different knock-out allele exhibit abnormal nervous system development and complete neonatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    78
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    490
  • Tissues
    370
  • cDNA Data
    31
  • Literature Summary
    77
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000021163 VEGA Gene Model | MGI Sequence Detail 8311 C57BL/6J ±  kb
    transcript OTTMUST00000050139 VEGA | MGI Sequence Detail 8311 Not Applicable  
    polypeptide OTTMUSP00000023364 VEGA | MGI Sequence Detail 395 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      61 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      cDNA 35
      Primer pair 8
      Other 3

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-14498, MGI:1913439, MGI:1915029, MGI:2144888
    References
    more
    • Summaries
      All 123
      Developmental Gene Expression 77
      Diseases 1
      Gene Ontology 15
      Phenotypes 24
    • Earliest
      J:4011 Wright EM, et al., Seven new members of the Sox gene family expressed during mouse development. Nucleic Acids Res. 1993 Feb 11;21(3):744
    • Latest
      J:261809 Mayer C, et al., Developmental diversification of cortical inhibitory interneurons. Nature. 2018 Mar 22;555(7697):457-462
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    07/10/2018
    MGI 6.12     		The Jackson Laboratory