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Sox11 Gene Detail
Summary
  • Symbol
    Sox11
  • Name
    SRY (sex determining region Y)-box 11
  • Synonyms
    1110038H03Rik, 6230403H02Rik, end1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98359
    NCBI Gene: 20666
  • Gene Overview
    MyGene.info: SOX11
Location & Maps
more
  • Sequence Map
    Chr12:27334264-27342574 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8311 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 9.95 cM, cytoband A3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SOX11, SRY-box 11
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SOX11, SRY-box 11
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MRD27
  • Links
    NCBI Gene ID: 6664
    neXtProt AC: NX_P35716

  • Chr Location
    2p25; chr2:5692667-5701385 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human SOX11 associations

Human Disease Mouse Models
       Mental Retardation, Autosomal Dominant 27; MRD27   OMIM: 615866
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    76 phenotypes from 6 alleles in 7 genetic backgrounds
    70 phenotypes from multigenic genotypes
    1 images
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display neonatal lethality with impaired ossification and impaired development of the heart, lung, spleen, stomach, skeleton and pancreas. Mice homozygous for a different knock-out allele exhibit abnormal nervous system development and complete neonatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021163 VEGA Gene Model | MGI Sequence Detail 8311 C57BL/6J ±  kb
transcript OTTMUST00000050139 VEGA | MGI Sequence Detail 8311 Not Applicable  
polypeptide OTTMUSP00000023364 VEGA | MGI Sequence Detail 395 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    61 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000015419 transcription factor SOX-11
  • InterPro Domains
    IPR009071 High mobility group box domain
    IPR029551 Transcription factor SOX-11
Molecular
Reagents
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  • All nucleic 43
    cDNA 34
    Primer pair 8
    Other 1

    Microarray probesets 8
Other
Accession IDs
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MGD-MRK-14498, MGI:1913439, MGI:1915029, MGI:2144888
References
more
  • Summaries
    All 108
    Developmental Gene Expression 68
    Gene Ontology 15
    Phenotypes 21
  • Earliest
    J:4011 Wright EM, et al., Seven new members of the Sox gene family expressed during mouse development. Nucleic Acids Res. 1993 Feb 11;21(3):744
  • Latest
    J:232434 Huang H, et al., Ablation of the Sox11 Gene Results in Clefting of the Secondary Palate Resembling the Pierre Robin Sequence. J Biol Chem. 2016 Mar 25;291(13):7107-18

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory