About   Help   FAQ
Snai1 Gene Detail
Summary
  • Symbol
    Snai1
  • Name
    snail family zinc finger 1
  • Synonyms
    Sna, Sna1, Snail, Snail1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98330
    NCBI Gene: 20613
  • Gene Overview
    MyGene.info: SNAI1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:167538195-167542814 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4620 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 87.33 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SNAI1, snail family transcriptional repressor 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SNAI1, snail family transcriptional repressor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    dJ710H13.1, SLUGH2, SNA, SNAH, SNAIL, SNAIL1
  • Links
    NCBI Gene ID: 6615
    neXtProt AC: NX_O95863
    UniProt: O95863

  • Chr Location
    20q13.13; chr20:49982976-49988886 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Snai1 mouse models

Human Disease Mouse Models
      
IDs
View 2 models
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    64 phenotypes from 7 alleles in 11 genetic backgrounds
    17 phenotypes from multigenic genotypes
    2 images
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit lethality by E8.5, reduced size, and abnormal mesoderm development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000001149 VEGA Gene Model | MGI Sequence Detail 4620 C57BL/6J ±  kb
    transcript OTTMUST00000002241 VEGA | MGI Sequence Detail 1621 Not Applicable  
    polypeptide OTTMUSP00000001090 VEGA | MGI Sequence Detail 264 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      21 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      Genomic 1
      cDNA 41
      Primer pair 7
      Other 9

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14460, MGI:2138858
    References
    more
    • Summaries
      All 270
      Developmental Gene Expression 170
      Diseases 2
      Gene Ontology 20
      Phenotypes 40
    • Earliest
      J:3088 Nieto MA, et al., Cloning and developmental expression of Sna, a murine homologue of the Drosophila snail gene. Development. 1992 Sep;116(1):227-37
    • Latest
      J:265181 Kim BJ, et al., RERE deficiency leads to decreased expression of GATA4 and the development of ventricular septal defects. Dis Model Mech. 2018 Aug 28;11(9)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    10/16/2018
    MGI 6.12
    The Jackson Laboratory