Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including epithelial to mesenchymal transition involved in endocardial cushion formation; positive regulation of epithelial to mesenchymal transition; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including hair follicle morphogenesis; negative regulation of cell differentiation involved in embryonic placenta development; and trophoblast giant cell differentiation. Located in cytoplasm and nucleus. Part of pericentric heterochromatin. Is expressed in several structures, including central nervous system; early conceptus; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human SNAI1 (snail family transcriptional repressor 1).