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Sstr2 Gene Detail
Summary
  • Symbol
    Sstr2
  • Name
    somatostatin receptor 2
  • Synonyms
    Smstr2, Smstr-2, sst2, SSTR-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98328
    NCBI Gene: 20606
  • Gene Overview
    MyGene.info: SSTR2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:113619481-113625895 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 79.05 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    77 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98328
protein coding gene Chr11:113619342-113626028 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019350
protein coding gene Chr11:117441646-117449962 (+)
A/J MGP_AJ_G0019318
protein coding gene Chr11:112384635-112393890 (+)
AKR/J MGP_AKRJ_G0019287
protein coding gene Chr11:115690420-115697097 (+)
BALB/cJ MGP_BALBcJ_G0019292
protein coding gene Chr11:112793292-112800777 (+)
C3H/HeJ MGP_C3HHeJ_G0019101
protein coding gene Chr11:116042566-116049230 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019742
protein coding gene Chr11:120967545-120976006 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017365
protein coding gene Chr11:109461775-109468380 (+)
CAST/EiJ MGP_CASTEiJ_G0018654
protein coding gene Chr11:117314421-117321079 (+)
CBA/J MGP_CBAJ_G0019070
protein coding gene Chr11:125897792-125906087 (+)
DBA/2J MGP_DBA2J_G0019182
protein coding gene Chr11:111822580-111829747 (+)
FVB/NJ MGP_FVBNJ_G0019173
protein coding gene Chr11:111297244-111304199 (+)
LP/J MGP_LPJ_G0019252
protein coding gene Chr11:117879659-117886354 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019204
protein coding gene Chr11:125050837-125060640 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019779
protein coding gene Chr11:116345241-116351937 (+)
PWK/PhJ MGP_PWKPhJ_G0018419
protein coding gene Chr11:113031143-113038461 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018211
protein coding gene Chr11:116156193-116162827 (+)
WSB/EiJ MGP_WSBEiJ_G0018706
protein coding gene Chr11:116301208-116307878 (+)



Homology
more
  • Human Ortholog
    SSTR2, somatostatin receptor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SSTR2, somatostatin receptor 2
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 6752
    neXtProt AC: NX_P30874
    UniProt: P30874

  • Chr Location
    17q25.1; chr17:73165021-73171955 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 4 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show elevated anxiety and locomotor and exploratory deficits. Homozygotes for a reporter allele show altered motor coordination, somatostatin-induced dopamine and glutamate release, retinal rod bipolar cells and EEG patterns, and reduced infarction after focal ischemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20606 NCBI Gene Model | MGI Sequence Detail 6415 C57BL/6J ±  kb
    transcript NM_009217 RefSeq | MGI Sequence Detail 1532 C57BL/6  
    polypeptide P30875 UniProt | EBI | MGI Sequence Detail 369 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 10
      cDNA 12
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-14455, MGD-MRK-14458
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 12
      Gene Ontology 9
      Phenotypes 26
    • Earliest
      J:2346 Yamada Y, et al., Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):251-5
    • Latest
      J:218669 Elliott AD, et al., Somatostatin and insulin mediate glucose-inhibited glucagon secretion in the pancreatic alpha-cell by lowering cAMP. Am J Physiol Endocrinol Metab. 2015 Jan 15;308(2):E130-43

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory