Sstr2
Gene Detail

Symbol Name ID

Sstr2 somatostatin receptor 2 MGI:98328

Synonyms

Smstr2, Smstr-2, sst2, SSTR-2

Feature Type

protein coding gene

Genetic Map

Chromosome 11

79.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:113619342-113626005 bp, + strand From VEGA annotation of GRCm38   6664 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37427  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: somatostatin receptor
Gene Tree: Sstr2

Human homologs

Human Homolog		SSTR2, somatostatin receptor 2
NCBI Gene ID		6752
neXtProt AC		NX_P30874
Human Chr (Location)		17q24; chr17:71161160-71168094 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygotes for a null allele show elevated anxiety and locomotor and exploratory deficits. Homozygotes for a reporter allele show altered motor coordination, somatostatin-induced dopamine and glutamate release, retinal rod bipolar cells and EEG patterns, and reduced infarction after focal ischemia.

 

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway, G-protein coupled receptor signaling pathway, ...
Component	cytoplasm, integral to membrane, ...
Function	G-protein coupled receptor activity, PDZ domain binding, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (122)    Tissues (68)    Images (12)
Theiler Stages: 19, 21, 22, 23, 28

Assay Type	Results
RNA in situ	28
RT-PCR	94

cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(26) Genomic(9) cDNA(12) Primer pair(3) Other(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000003400 (Evidence)
Ensembl Gene Model	ENSMUSG00000047904 (Evidence)
Entrez Gene	20606 (Evidence)
DFCI	TC1596959, TC1599317
DoTS	DT.91481025
NIA Mouse Gene Index	U013516
Consensus CDS Project	CCDS25598.1
International Mouse Knockout Project Status	Sstr2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000003400	VEGA Gene Model | MGI Sequence Detail	6664	C57BL/6J
transcript	OTTMUST00000007140	VEGA | MGI Sequence Detail	1537	Not Applicable
polypeptide	OTTMUSP00000003405	VEGA | MGI Sequence Detail	346	Not Applicable

All sequences(29) RefSeq(4) UniProt(2)

Polymorphisms

RFLP(2) : SNPs(13 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000586	Somatostatin receptor
InterPro	IPR002074	Somatostatin receptor, type 2
Protein Ontology	PR:000001669	somatostatin receptor 2

References

(Earliest) J:2346 Yamada Y, et al., Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):251-5
(Latest) J:190646 Bodmer D, et al., Somatostatin receptor types 1 and 2 in the developing Mammalian cochlea. Dev Neurosci. 2012;34(4):342-53
All references(77)

Other accession IDs

MGD-MRK-14455, MGD-MRK-14458