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Sstr2
Gene Detail
 Symbol
Name
ID
Sstr2
somatostatin receptor 2
MGI:98328
Synonyms Smstr2, Smstr-2, sst2, SSTR-2
Feature Type protein coding gene
Genetic Map
Chromosome 11
79.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:113619342-113626028 bp, + strand
From VEGA annotation of GRCm38

  6687 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37427  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: somatostatin receptor
Gene Tree: Sstr2

Human
homologs
Human Homolog SSTR2, somatostatin receptor 2
NCBI Gene ID 6752
neXtProt AC  NX_P30874
Human Chr (Location)  17q24; chr17:73165021-73171955 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele show elevated anxiety and locomotor and exploratory deficits. Homozygotes for a reporter allele show altered motor coordination, somatostatin-induced dopamine and glutamate release, retinal rod bipolar cells and EEG patterns, and reduced infarction after focal ischemia.
 
Interactions
Sstr2 interacts with 73 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway, G-protein coupled receptor signaling pathway, ...
Component cytoplasm, integral component of membrane, ...
Function G-protein coupled receptor activity, PDZ domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (122)    Tissues (68)    Images (12)
Theiler Stages: 19, 21, 22, 23, 28
Assay TypeResults
RNA in situ 28
RT-PCR 94
cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) Genomic(9) cDNA(12) Primer pair(3) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000003400 (Evidence)
Ensembl Gene ModelENSMUSG00000047904 (Evidence)
Entrez Gene20606 (Evidence)
DFCITC1596959, TC1599317
DoTSDT.91481025
NIA Mouse Gene IndexU013516
Consensus CDS ProjectCCDS25598.1, CCDS59571.1
International Mouse Knockout Project StatusSstr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003400 VEGA Gene Model | MGI Sequence Detail 6687 C57BL/6J ±  kb
transcript OTTMUST00000007141 VEGA | MGI Sequence Detail 2143 Not Applicable 
polypeptide OTTMUSP00000065122 VEGA | MGI Sequence Detail 369 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(4) UniProt(1)
Polymorphisms RFLP(2) : SNPs within 2kb(82 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR002074 Somatostatin receptor 2
InterPro IPR000586 Somatostatin receptor family
Protein Ontology PR:000001669 somatostatin receptor type 2
References (Earliest) J:2346 Yamada Y, et al., Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):251-5
(Latest) J:203529 Zhao P, et al., Agonist-biased trafficking of somatostatin receptor 2A in enteric neurons. J Biol Chem. 2013 Sep 6;288(36):25689-700
All references(79)
Other
accession IDs
MGD-MRK-14455, MGD-MRK-14458

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory