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Sstr2 Gene Detail
Summary
  • Symbol
    Sstr2
  • Name
    somatostatin receptor 2
  • Synonyms
    Smstr2, Smstr-2, sst2, SSTR-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98328
    NCBI Gene: 20606
  • Gene Overview
    MyGene.info: SSTR2
Location & Maps
more
  • Sequence Map
    Chr11:113619342-113626028 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6687 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 79.05 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SSTR2, somatostatin receptor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SSTR2, somatostatin receptor 2
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 6752
    neXtProt AC: NX_P30874

  • Chr Location
    17q24; chr17:73165021-73171955 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 3 alleles in 4 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show elevated anxiety and locomotor and exploratory deficits. Homozygotes for a reporter allele show altered motor coordination, somatostatin-induced dopamine and glutamate release, retinal rod bipolar cells and EEG patterns, and reduced infarction after focal ischemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003400 VEGA Gene Model | MGI Sequence Detail 6687 C57BL/6J ±  kb
transcript OTTMUST00000007141 VEGA | MGI Sequence Detail 2143 Not Applicable  
polypeptide OTTMUSP00000065122 VEGA | MGI Sequence Detail 369 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    79 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000001669 somatostatin receptor type 2
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR002074 Somatostatin receptor 2
    IPR000586 Somatostatin receptor family
Molecular
Reagents
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  • All nucleic 26
    Genomic 9
    cDNA 12
    Primer pair 3
    Other 2

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-14455, MGD-MRK-14458
References
more
  • Summaries
    All 78
    Developmental Gene Expression 11
    Gene Ontology 8
    Phenotypes 26
  • Earliest
    J:2346 Yamada Y, et al., Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):251-5
  • Latest
    J:218669 Elliott AD, et al., Somatostatin and insulin mediate glucose-inhibited glucagon secretion in the pancreatic alpha-cell by lowering cAMP. Am J Physiol Endocrinol Metab. 2015 Jan 15;308(2):E130-43

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory