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C4a Gene Detail
Summary
  • Symbol
    C4a
  • Name
    complement component 4A (Rodgers blood group)
  • Synonyms
    Slp
Location & Maps
more
  • Sequence Map
    Chr17:34809092-34823464 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14373 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.37 cM
  • Mapping Data
    12 experiments
Homology
more
  • Human Ortholog
    C4A, complement component 4A (Rodgers blood group)
  • Vertebrate Orthologs
    12
  • Human Ortholog
    C4A, complement component 4A (Rodgers blood group)
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C4, C4A2, C4A3, C4A4, C4A6, C4AD, C4S, CO4, CPAMD2, RG
  • Links
    NCBI Gene ID: 720
    neXtProt AC: NX_P0C0L4

  • Chr Location
    6p21.3; chr6:31982057-32002680 (+)  GRCh38.p2

  • Human Ortholog
    C4B, complement component 4B (Chido blood group)
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C4B1, C4B12, C4B2, C4B_2, C4B3, C4B5, C4BD, C4F, CH, CO4, CPAMD3
  • Links
    NCBI Gene ID: 721
    neXtProt AC: NX_P0C0L4, NX_P0C0L5

  • Chr Location
    6p21.3; chr6:32014795-32035418 (+)  GRCh38.p2

Human Diseases
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  • Diseases
    2 with human C4A,C4B associations

Human Disease Mouse Models
       Complement Component 4a Deficiency; C4AD   OMIM: 614380
Complement Component 4b Deficiency; C4BD   OMIM: 614379
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Sequences &
Gene Models
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  • All Sequences
  • RefSeq
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033087 VEGA Gene Model | MGI Sequence Detail 14373 C57BL/6J ±  kb
transcript NM_011413 RefSeq | MGI Sequence Detail 5369 Not Specified  
polypeptide NP_035543 RefSeq | MGI Sequence Detail 1735 Not Specified  
For the selected sequence
Polymorphisms
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  • RFLP
Molecular
Reagents
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  • All nucleic 87
    Genomic 71
    cDNA 14
    Other 2

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-14443
References
more
  • Summaries
    All 67
    Gene Ontology 5
  • Earliest
    J:5181 Passmore HC, et al., A sex-limited serum protein variant in the mouse: inheritance and association with the H-2 region. Biochem Genet. 1970 Jun;4(3):351-65
  • Latest
    J:86324 Krebs CJ, et al., Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression. Genes Dev. 2003 Nov 1;17(21):2664-74

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory