About   Help   FAQ
Shmt1
Gene Detail
Symbol

Name
ID
Shmt1
serine hydroxymethyltransferase 1 (soluble)
MGI:98299
Synonyms
mshmt, mshmt1, mshmt2, Shmt
Feature Type
protein coding gene
Genetic Map
Chromosome 11
37.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:60788104-60811718 bp, - strand
From VEGA annotation of GRCm38

  23615 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3074  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: serine/glycine hydroxymethyltransferase
Gene Tree: Shmt1

Human
homologs
Human Homolog SHMT1, serine hydroxymethyltransferase 1 (soluble)
NCBI Gene ID 6470
neXtProt AC  NX_P34896
Human Synonyms  CSHMT, SHMT
Human Chr (Location)  17p11.2; chr17:18327860-18363563 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(42) : Gene trapped(36) Targeted(6)
Genomic Mutations involving Shmt1 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice with deficiencies in this gene display abnormalities in hepatic partioning of methylenetetrahydrofolate but are otherwise healthy and fertile.
 
Alleles Annotated to Human Diseases(2)   
Interactions
Shmt1 interacts with 148 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process folic acid metabolic process, glycine biosynthetic process, ...
Component cytoplasm, cytosol, ...
Function amino acid binding, catalytic activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (75)    Tissues (14)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 75
cDNA source data(138)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(139) cDNA(138) Primer pair(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000007760 (Evidence)
Ensembl Gene ModelENSMUSG00000020534 (Evidence)
Entrez Gene20425 (Evidence)
UniGene364956
DFCITC1575515, TC1683855, TC1637604, TC1587399
DoTSDT.101404041, DT.97412438, DT.484913, DT.101404042
EC2.1.2.1
PDB1EJI
Consensus CDS ProjectCCDS24799.1
International Mouse Knockout Project StatusShmt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007760 VEGA Gene Model | MGI Sequence Detail 23615 C57BL/6J ±  kb
transcript OTTMUST00000017725 VEGA | MGI Sequence Detail 2858 Not Applicable 
polypeptide OTTMUSP00000008170 VEGA | MGI Sequence Detail 478 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(4) UniProt(9)
Polymorphisms
SNPs within 2kb(220 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015424 Pyridoxal phosphate-dependent transferase
InterPro IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1
InterPro IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2
InterPro IPR001085 Serine hydroxymethyltransferase
InterPro IPR019798 Serine hydroxymethyltransferase, pyridoxal phosphate binding site
Protein Ontology PR:000014847 serine hydroxymethyltransferase, cytosolic
References
(Earliest) J:36385 Nakshatri H, et al., Isolation of retinoic acid-repressed genes from P19 embryonal carcinoma cells. Gene. 1996 Sep 26;174(1):79-84
(Latest) J:183477 Nilsson LM, et al., Mouse genetics suggests cell-context dependency for Myc-regulated metabolic enzymes during tumorigenesis. PLoS Genet. 2012 Mar;8(3):e1002573
All references(49)
Other
accession IDs
MGD-MRK-14406, MGI:2144126, MGI:2144138, MGI:2144665

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/18/2014
MGI 5.20
The Jackson Laboratory