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Shc1 Gene Detail
Summary
  • Symbol
    Shc1
  • Name
    src homology 2 domain-containing transforming protein C1
  • Synonyms
    p66, p66shc, ShcA
  • Feature Type
    protein coding gene
  • IDs
    MGI:98296
    NCBI Gene: 20416
  • Gene Overview
    MyGene.info: SHC1
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:89418443-89430027 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 39.11 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    40 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98296
protein coding gene Chr3:89418402-89430029 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027439
protein coding gene Chr3:89632987-89645071 (+)
A/J MGP_AJ_G0027403
protein coding gene Chr3:86666656-86678876 (+)
AKR/J MGP_AKRJ_G0027367
protein coding gene Chr3:88763448-88777015 (+)
BALB/cJ MGP_BALBcJ_G0027412
protein coding gene Chr3:86633937-86646150 (+)
C3H/HeJ MGP_C3HHeJ_G0027154
protein coding gene Chr3:88966920-88980153 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027858
protein coding gene Chr3:93019241-93030640 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025210
protein coding gene Chr3:82149359-82162528 (+)
CAST/EiJ MGP_CASTEiJ_G0026600
protein coding gene Chr3:89323415-89336000 (+)
CBA/J MGP_CBAJ_G0027128
protein coding gene Chr3:96209022-96223365 (+)
DBA/2J MGP_DBA2J_G0027266
protein coding gene Chr3:86044290-86056898 (+)
FVB/NJ MGP_FVBNJ_G0027234
protein coding gene Chr3:84387257-84397009 (+)
LP/J MGP_LPJ_G0027375
protein coding gene Chr3:90712597-90725238 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027254
protein coding gene Chr3:102418687-102430367 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027917
protein coding gene Chr3:88519437-88532679 (+)
PWK/PhJ MGP_PWKPhJ_G0026334
protein coding gene Chr3:85922657-85933497 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026153
protein coding gene Chr3:87693114-87708900 (+)
WSB/EiJ MGP_WSBEiJ_G0026682
protein coding gene Chr3:88912269-88929491 (+)



Homology
more
  • Human Ortholog
    SHC1, SHC adaptor protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SHC1, SHC adaptor protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SHC, SHCA
  • Links
    NCBI Gene ID: 6464
    neXtProt AC: NX_P29353
    UniProt: P29353

  • Chr Location
    1q21.3; chr1:154962298-154974492 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    53 phenotypes from 13 alleles in 7 genetic backgrounds
    19 phenotypes from multigenic genotypes
    73 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes with a targeted mutation of the exon encoding the CH2 region show an extended life span, reduced cellular sensitivity to oxidative stress and UV irradiation, and resistance to diet-induced atherogenesis. Homozygotes lacking all three isoformsdie around E11.5 with cardiovascular defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042626 Ensembl Gene Model | MGI Sequence Detail 11585 C57BL/6J ±  kb
    transcript ENSMUST00000094378 Ensembl | MGI Sequence Detail 2617 Not Applicable  
    polypeptide ENSMUSP00000091940 Ensembl | MGI Sequence Detail 579 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 112
      Genomic 1
      cDNA 109
      Primer pair 1
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-14402
    References
    more
    • Summaries
      All 161
      Developmental Gene Expression 14
      Diseases 1
      Gene Ontology 23
      Phenotypes 73
    • Earliest
      J:17164 Pelicci G, et al., A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell. 1992 Jul 10;70(1):93-104
    • Latest
      J:253031 Granatiero V, et al., Role of p66shc in skeletal muscle function. Sci Rep. 2017 Jul 24;7(1):6283

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory