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Shc1 Gene Detail
Summary
  • Symbol
    Shc1
  • Name
    src homology 2 domain-containing transforming protein C1
  • Synonyms
    p66, p66shc, ShcA
  • Feature Type
    protein coding gene
  • IDs
    MGI:98296
    NCBI Gene: 20416
  • Gene Overview
    MyGene.info: SHC1
Location & Maps
more
  • Sequence Map
    Chr3:89418443-89430015 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11573 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 39.11 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SHC1, SHC adaptor protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SHC1, SHC adaptor protein 1
    Orthology source: HomoloGene
  • Synonyms
    SHC, SHCA
  • Links
    NCBI Gene ID: 6464
    neXtProt AC: NX_P29353

  • Chr Location
    1q21; chr1:154962298-154974492 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    52 phenotypes from 13 alleles in 7 genetic backgrounds
    19 phenotypes from multigenic genotypes
    67 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    81
  • Chemically induced (other)
    1
  • Gene trapped
    62
  • Radiation induced
    1
  • Targeted
    15
  • Transgenic
    2
  • Genomic Mutations
    2 involving Shc1
  • Incidental Mutations
Homozygotes with a targeted mutation of the exon encoding the CH2 region show an extended life span, reduced cellular sensitivity to oxidative stress and UV irradiation, and resistance to diet-induced atherogenesis. Homozygotes lacking all three isoformsdie around E11.5 with cardiovascular defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022071 VEGA Gene Model | MGI Sequence Detail 11573 C57BL/6J ±  kb
transcript OTTMUST00000052404 VEGA | MGI Sequence Detail 2617 Not Applicable  
polypeptide OTTMUSP00000024848 VEGA | MGI Sequence Detail 579 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    40 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 109
    Genomic 1
    cDNA 107
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-14402
References
more
  • Summaries
    All 132
    Developmental Gene Expression 14
    Gene Ontology 20
    Phenotypes 67
  • Earliest
    J:17164 Pelicci G, et al., A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell. 1992 Jul 10;70(1):93-104
  • Latest
    J:229198 Lunghi B, et al., Smoking p66Shc knocked out mice develop respiratory bronchiolitis with fibrosis but not emphysema. PLoS One. 2015;10(3):e0119797

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory