Shc1
Gene Detail

Symbol Name ID

Shc1 src homology 2 domain-containing transforming protein C1 MGI:98296

Synonyms

p66, p66shc, ShcA

Feature Type

protein coding gene

Genetic Map

Chromosome 3

39.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr3:89418443-89430015 bp, + strand From VEGA annotation of GRCm38   11573 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Shc1 ± 2 cM)

Protein SuperFamily: SHC-transforming protein
Gene Tree: Shc1

Human ortholog

SHC1 SHC (Src homology 2 domain containing) transforming protein 1 NCBI Gene ID 6464
Human Synonyms: SHC, SHCA
Human Chr1:154934774-154946959 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(77) : Targeted(15) Gene trapped(62)
 

Homozygotes with a targeted mutation of the exon encoding the CH2 region show an extended life span, reduced cellular sensitivity to oxidative stress and UV irradiation, and resistance to diet-induced atherogenesis. Homozygotes lacking all three isoforms die around E11.5 with cardiovascular defects.

 

Gene Ontology (GO) classifications

All GO classifications: (38 annotations)

Process	actin cytoskeleton organization, actin cytoskeleton reorganization, ...
Component	cytoplasm, endosome membrane, ...
Function	ephrin receptor binding, epidermal growth factor receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (13 records)
Data Summary: Results (25)    Tissues (20)    Images (8)
Theiler Stages: 19, 20, 21, 22, 24, 28

Assay Type	Results
Immunohistochemistry	13
RNA in situ	2
RT-PCR	10

cDNA source data(99)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(105) Genomic(1) cDNA(103) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000022071 (Evidence)
Ensembl Gene Model	ENSMUSG00000042626 (Evidence)
Entrez Gene	20416 (Evidence)
UniGene	86595
DFCI	TC1576486, TC1618328, TC1700526
DoTS	DT.101180654, DT.101385146, DT.101385152, DT.103563474, DT.110749809, DT.491522
Consensus CDS Project	CCDS17508.1, CCDS50962.1
International Mouse Knockout Project Status	Shc1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022071	VEGA Gene Model | MGI Sequence Detail	11573	C57BL/6J
transcript	OTTMUST00000052404	VEGA | MGI Sequence Detail	2617	Not Applicable
polypeptide	OTTMUSP00000024848	VEGA | MGI Sequence Detail	579	Not Applicable

All sequences(80) RefSeq(4) UniProt(5)

Polymorphisms

RFLP(1) : SNPs(35 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006020	Phosphotyrosine interaction domain
InterPro	IPR006019	Phosphotyrosine interaction (PID/PI)
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR000980	SH2 domain
Protein Ontology	PR:000003178	shc-transforming protein 1

References

(Earliest) J:17164 Pelicci G, et al., A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell. 1992 Jul 10;70(1):93-104
(Latest) J:192597 Bock F, et al., Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc. Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):648-53
All references(110)

Other accession IDs

MGD-MRK-14402