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Shc1
Gene Detail
Symbol

Name
ID
Shc1
src homology 2 domain-containing transforming protein C1
MGI:98296
Synonyms
p66, p66shc, ShcA
Feature Type
protein coding gene
Genetic Map
Chromosome 3
39.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:89418443-89430015 bp, + strand
From VEGA annotation of GRCm38

  11573 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7934  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SHC1
Protein SuperFamily: SHC-transforming protein
Gene Tree: Shc1

Human
homologs
SHC1, SHC (Src homology 2 domain containing) transforming protein 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6464
neXtProt AC: NX_P29353

Human Synonyms: SHC, SHCA

Human Chr (Location): 1q21; chr1:154962298-154974492 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(79) : Gene trapped(62) Targeted(15) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes with a targeted mutation of the exon encoding the CH2 region show an extended life span, reduced cellular sensitivity to oxidative stress and UV irradiation, and resistance to diet-induced atherogenesis. Homozygotes lacking all three isoforms die around E11.5 with cardiovascular defects.
 
Interactions
Shc1 interacts with 229 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (49 annotations)
Process actin cytoskeleton organization, actin cytoskeleton reorganization, ...
Component cytoplasm, endosome membrane, ...
Function ephrin receptor binding, epidermal growth factor receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (25)    Tissues (20)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 13
RNA in situ 2
RT-PCR 10
cDNA source data(103)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase shc1    NEW 
Molecular
reagents
All nucleic(109) Genomic(1) cDNA(107) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000022071 (Evidence)
Ensembl Gene Model ENSMUSG00000042626 (Evidence)
Entrez Gene 20416 (Evidence)
UniGene 86595
DFCI TC1576486, TC1618328, TC1700526
NIA Mouse Gene Index U003466, U142377
Consensus CDS Project CCDS17508.1, CCDS50962.1
International Mouse Phenotyping Consortium Status Shc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022071 VEGA Gene Model | MGI Sequence Detail 11573 C57BL/6J ±  kb
transcript OTTMUST00000052404 VEGA | MGI Sequence Detail 2617 Not Applicable 
polypeptide OTTMUSP00000024848 VEGA | MGI Sequence Detail 579 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(8) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(40 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006020 Phosphotyrosine interaction domain
InterPro IPR006019 Phosphotyrosine interaction (PID/PI)
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR000980 SH2 domain
Protein Ontology PR:000003178 shc-transforming protein 1
References
(Earliest) J:17164 Pelicci G, et al., A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell. 1992 Jul 10;70(1):93-104
(Latest) J:220826 Natalicchio A, et al., The p66(Shc) redox adaptor protein is induced by saturated fatty acids and mediates lipotoxicity-induced apoptosis in pancreatic beta cells. Diabetologia. 2015 Jun;58(6):1260-71
All references(131)
Other
accession IDs
MGD-MRK-14402

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory