Srsf1 MGI Mouse Gene Detail - MGI:98283 - serine/arginine-rich splicing factor 1

Srsf1 Gene Detail

Symbol

Srsf1
Name

serine/arginine-rich splicing factor 1
Synonyms

1110054N12Rik, 5730507C05Rik, 6330415C05Rik, Sfrs1

Feature Type

protein coding gene
IDs

MGI:98283
NCBI Gene: 110809
Gene Overview

MyGene.info: SRSF1

Sequence Map

Chr11:88047373-88053755 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

6383 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 52.40 cM
Mapping Data

8 experiments

Human Ortholog

SRSF1, serine and arginine rich splicing factor 1

Vertebrate Orthologs

10

Human Ortholog

SRSF1, serine and arginine rich splicing factor 1
Orthology source: HomoloGene, HGNC
Synonyms

ASF, SF2, SF2p33, SFRS1, SRp30a
Links

HGNC:10780

NCBI Gene ID: 6426

neXtProt AC: NX_Q07955

UniProt: Q07955
Chr Location

17q22; chr17:58000919-58007346 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 31411
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: SRSF1
Gene Tree

Srsf1

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References

1 with disease annotations

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Phenotype Summary

19 phenotypes from 2 alleles in 2 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

75
Chemically induced (other)

1
Gene trapped

68
Targeted

6
Genomic Mutations

4 involving Srsf1
Incidental Mutations

APF
Find Mice (IMSR)

73 strains or lines available

Homozygous null mice display early embryonic lethality. Cardiac specific conditional deletion mutants shows cardiac malfunction and premature death.

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All GO Annotations

31
GO References

15

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

53
Tissues

53
cDNA Data

22
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase srsf1

ZFIN srsf1a, srsf1b

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Srsf1 interacts with 479 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

66
RefSeq

5
UniProt

4
CCDS

CCDS36273.1, CCDS36274.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000001473	VEGA Gene Model \| MGI Sequence Detail	6383	C57BL/6J	± kb
transcript	OTTMUST00000093491	VEGA \| MGI Sequence Detail	1209	Not Applicable
polypeptide	OTTMUSP00000051863	VEGA \| MGI Sequence Detail	253	Not Applicable

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RFLP

2

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UniProt

4 Sequences
Protein Ontology

PR:000014748 splicing factor, arginine/serine-rich 1

(term hierarchy)
PDB

1X4C
InterPro Domains

IPR000504 RNA recognition motif domain

IPR034520 SRSF1, RNA recognition motif 1

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All nucleic 26

cDNA 24

Primer pair 1

Other 1

Microarray probesets 13

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MGD-MRK-14371, MGI:1916007, MGI:1917883, MGI:1917974, MGI:2144200, MGI:2144540

Summaries

All 67

Developmental Gene Expression 4

Diseases 1

Gene Ontology 15

Phenotypes 17
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:236188 Cheng Y, et al., Liver-Specific Deletion of SRSF2 Caused Acute Liver Failure and Early Death in Mice. Mol Cell Biol. 2016 Jun 1;36(11):1628-38

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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