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Srsf1
Gene Detail
 Symbol
Name
ID
Srsf1
serine/arginine-rich splicing factor 1
MGI:98283
Synonyms 1110054N12Rik, 5730507C05Rik, 6330415C05Rik, Sfrs1
Feature Type protein coding gene
Genetic Map
Chromosome 11
52.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr11:88047373-88053755 bp, + strand
From VEGA annotation of GRCm38

  6383 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31411  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Srsf1

Human
homologs
Human Homolog SRSF1, serine/arginine-rich splicing factor 1
NCBI Gene ID 6426
neXtProt AC  NX_Q07955
Human Synonyms  ASF, SF2, SF2p33, SFRS1, SRp30a
Human Chr (Location)  17q22; chr17:58000919-58007346 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(73) : Gene trapped(68) Targeted(5)
Genomic Mutations involving Srsf1 (2)
Incidental mutations (data from APF )
 
Homozygous null mice display early embryonic lethality. Cardiac specific conditional deletion mutants shows cardiac malfunction and premature death.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Srsf1 interacts with 479 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process cardiac muscle contraction, in utero embryonic development, ...
Component catalytic step 2 spliceosome, cytoplasm, ...
Function mRNA binding, nucleic acid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (53)    Tissues (53)    Images (11)
Theiler Stages: 19, 21, 23, 27, 28
Assay TypeResults
RNA in situ 51
RT-PCR 2
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) cDNA(24) Primer pair(1) Other(1)
Microarray probesets(13)
Other database
links
VEGA Gene ModelOTTMUSG00000001473 (Evidence)
Ensembl Gene ModelENSMUSG00000018379 (Evidence)
Entrez Gene110809 (Evidence)
DFCITC1573137, TC1580635, TC1585059, TC1600703, TC1603790, TC1668524, TC1677251, TC1714571
DoTSDT.101207952, DT.101391396, DT.101391398, DT.110512255, DT.496539, DT.91281569, DT.94313573, DT.94313600, DT.97388751
NIA Mouse Gene IndexU013154, U195045
PDB1X4C
Consensus CDS ProjectCCDS36273.1, CCDS36274.1
International Mouse Knockout Project StatusSrsf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001473 VEGA Gene Model | MGI Sequence Detail 6383 C57BL/6J ±  kb
transcript OTTMUST00000093491 VEGA | MGI Sequence Detail 1209 Not Applicable 
polypeptide OTTMUSP00000051863 VEGA | MGI Sequence Detail 253 Not Applicable 

For the selected sequences
All sequences(86) RefSeq(6) UniProt(4)
Polymorphisms RFLP(2) : SNPs within 2kb(35 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR000504 RNA recognition motif domain
Protein Ontology PR:000014748 splicing factor, arginine/serine-rich 1
References (Earliest) J:25670 Ayane M, et al., A differentially expressed murine RNA encoding a protein with similarities to two types of nucleic acid binding motifs. Nucleic Acids Res. 1991 Mar 25;19(6):1273-8
(Latest) J:206891 Ji X, et al., SR proteins collaborate with 7SK and promoter-associated nascent RNA to release paused polymerase. Cell. 2013 May 9;153(4):855-68
All references(60)
Other
accession IDs
MGD-MRK-14371, MGI:1916007, MGI:1917883, MGI:1917974, MGI:2144200, MGI:2144540

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory