Srsf1
Gene Detail

Symbol

Name
ID

Srsf1
serine/arginine-rich splicing factor 1
MGI:98283

Synonyms

1110054N12Rik, 5730507C05Rik, 6330415C05Rik, Sfrs1

Feature Type

protein coding gene

Genetic Map

Chromosome 11
52.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr11:88047373-88053755 bp, + strand From VEGA annotation of GRCm38   6383 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:31411  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Srsf1

Human
homologs

Human Homolog		SRSF1, serine/arginine-rich splicing factor 1
NCBI Gene ID		6426
neXtProt AC		NX_Q07955
Human Synonyms		ASF, SF2, SF2p33, SFRS1, SRp30a
Human Chr (Location)		17q22; chr17:58000919-58007346 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(74) : Gene trapped(68) Targeted(6)
Genomic Mutations involving Srsf1 (3)
Incidental mutations (data from APF )
 

Homozygous null mice display early embryonic lethality. Cardiac specific conditional deletion mutants shows cardiac malfunction and premature death.

 
Mutations Annotated to Human Diseases (1)   

Interactions

Srsf1 interacts with 479 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (31 annotations)

Process	cardiac muscle contraction, in utero embryonic development, ...
Component	catalytic step 2 spliceosome, cytoplasm, ...
Function	mRNA binding, nucleic acid binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)

Data Summary: Results (53)    Tissues (53)    Images (11)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	51
RT-PCR	2

cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(26) cDNA(24) Primer pair(1) Other(1)
Microarray probesets(13)

Other database
links

VEGA Gene Model	OTTMUSG00000001473 (Evidence)
Ensembl Gene Model	ENSMUSG00000018379 (Evidence)
Entrez Gene	110809 (Evidence)
DFCI	TC1573137, TC1580635, TC1585059, TC1600703, TC1603790, TC1668524, TC1677251, TC1714571
DoTS	DT.101207952, DT.101391396, DT.101391398, DT.110512255, DT.496539, DT.91281569, DT.94313573, DT.94313600, DT.97388751
NIA Mouse Gene Index	U013154, U195045
PDB	1X4C
Consensus CDS Project	CCDS36273.1, CCDS36274.1
International Mouse Knockout Project Status	Srsf1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000001473	VEGA Gene Model | MGI Sequence Detail	6383	C57BL/6J
transcript	OTTMUST00000093491	VEGA | MGI Sequence Detail	1209	Not Applicable
polypeptide	OTTMUSP00000051863	VEGA | MGI Sequence Detail	253	Not Applicable

All sequences(86) RefSeq(6) UniProt(4)

Polymorphisms

RFLP(2) : SNPs within 2kb(35 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR012677	Nucleotide-binding, alpha-beta plait
InterPro	IPR000504	RNA recognition motif domain
Protein Ontology	PR:000014748	splicing factor, arginine/serine-rich 1

References

(Earliest) J:25670 Ayane M, et al., A differentially expressed murine RNA encoding a protein with similarities to two types of nucleic acid binding motifs. Nucleic Acids Res. 1991 Mar 25;19(6):1273-8
(Latest) J:206891 Ji X, et al., SR proteins collaborate with 7SK and promoter-associated nascent RNA to release paused polymerase. Cell. 2013 May 9;153(4):855-68
All references(60)

Other
accession IDs

MGD-MRK-14371, MGI:1916007, MGI:1917883, MGI:1917974, MGI:2144200, MGI:2144540