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Srsf1 Gene Detail
Summary
  • Symbol
    Srsf1
  • Name
    serine/arginine-rich splicing factor 1
  • Synonyms
    1110054N12Rik, 5730507C05Rik, 6330415C05Rik, Sfrs1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98283
    NCBI Gene: 110809
  • Gene Overview
    MyGene.info: SRSF1
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr11:88047373-88053755 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      6383 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 52.40 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    SRSF1, serine and arginine rich splicing factor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SRSF1, serine and arginine rich splicing factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ASF, SF2, SF2p33, SFRS1, SRp30a
  • Links
    NCBI Gene ID: 6426
    neXtProt AC: NX_Q07955
    UniProt: Q07955

  • Chr Location
    17q22; chr17:58000919-58007346 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 31411
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SRSF1
  • Gene Tree
    Srsf1
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display early embryonic lethality. Cardiac specific conditional deletion mutants shows cardiac malfunction and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    53
  • Tissues
    53
  • cDNA Data
    21
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000001473 VEGA Gene Model | MGI Sequence Detail 6383 C57BL/6J ±  kb
    transcript OTTMUST00000093491 VEGA | MGI Sequence Detail 1209 Not Applicable  
    polypeptide OTTMUSP00000051863 VEGA | MGI Sequence Detail 253 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • RFLP
      2
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • PDB
      1X4C
    • InterPro Domains
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
      IPR029538 Serine/arginine-rich splicing factor 1
      IPR034520 SRSF1, RNA recognition motif 1
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 23
      Primer pair 1
      Other 1

      Microarray probesets 13
    Other
    Accession IDs
    less
    MGD-MRK-14371, MGI:1916007, MGI:1917883, MGI:1917974, MGI:2144200, MGI:2144540
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 15
      Phenotypes 18
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:256883 Zhou J, et al., Conserved expression of ultra-conserved noncoding RNA in mammalian nervous system. Biochim Biophys Acta. 2017 Dec;1860(12):1159-1168
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    05/15/2018
    MGI 6.12     		The Jackson Laboratory