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Srsf1 Gene Detail
Summary
  • Symbol
    Srsf1
  • Name
    serine/arginine-rich splicing factor 1
  • Synonyms
    1110054N12Rik, 5730507C05Rik, 6330415C05Rik, Sfrs1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98283
    NCBI Gene: 110809
  • Gene Overview
    MyGene.info: SRSF1
Location & Maps
more
  • Sequence Map
    Chr11:88047373-88053755 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      6383 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 52.40 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    SRSF1, serine and arginine rich splicing factor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SRSF1, serine and arginine rich splicing factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ASF, SF2, SF2p33, SFRS1, SRp30a
  • Links
    NCBI Gene ID: 6426
    neXtProt AC: NX_Q07955

  • Chr Location
    17q22; chr17:58000919-58007346 (-)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 31411
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: SRSF1
  • Gene Tree
    Srsf1
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    75
  • Chemically induced (other)
    1
  • Gene trapped
    68
  • Targeted
    6
  • Genomic Mutations
    4 involving Srsf1
  • Incidental Mutations
    APF
Homozygous null mice display early embryonic lethality. Cardiac specific conditional deletion mutants shows cardiac malfunction and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    53
  • Tissues
    53
  • cDNA Data
    22
  • Literature Summary
    4
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001473 VEGA Gene Model | MGI Sequence Detail 6383 C57BL/6J ±  kb
transcript OTTMUST00000093491 VEGA | MGI Sequence Detail 1209 Not Applicable  
polypeptide OTTMUSP00000051863 VEGA | MGI Sequence Detail 253 Not Applicable  
For the selected sequence
Polymorphisms
less
  • RFLP
    2
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000014748 splicing factor, arginine/serine-rich 1
  • PDB
    1X4C
  • InterPro Domains
    IPR012677 Nucleotide-binding alpha-beta plait domain
    IPR000504 RNA recognition motif domain
Molecular
Reagents
less
  • All nucleic 26
    cDNA 24
    Primer pair 1
    Other 1

    Microarray probesets 13
Other
Accession IDs
less
MGD-MRK-14371, MGI:1916007, MGI:1917883, MGI:1917974, MGI:2144200, MGI:2144540
References
more
  • Summaries
    All 57
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 15
    Phenotypes 16
  • Earliest
    J:25670 Ayane M, et al., A differentially expressed murine RNA encoding a protein with similarities to two types of nucleic acid binding motifs. Nucleic Acids Res. 1991 Mar 25;19(6):1273-8
  • Latest
    J:206891 Ji X, et al., SR proteins collaborate with 7SK and promoter-associated nascent RNA to release paused polymerase. Cell. 2013 May 9;153(4):855-68
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory