Srsf1 MGI Mouse Gene Detail - MGI:98283 - serine and arginine-rich splicing factor 1

Symbol

Srsf1
Name

serine and arginine-rich splicing factor 1
Synonyms

1110054N12Rik, 5730507C05Rik, 6330415C05Rik, Sfrs1

Feature Type

protein coding gene
IDs

MGI:98283
NCBI Gene: 110809
Gene Overview

MyGene.info: SRSF1
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr11:88047373-88053755 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 52.40 cM
Mapping Data

8 experiments

Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98283	protein coding gene	Chr11:88046499-88053757 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018919	protein coding gene	Chr11:89728139-89734516 (+)
A/J	MGP_AJ_G0018887	protein coding gene	Chr11:86252050-86258427 (+)
AKR/J	MGP_AKRJ_G0018857	protein coding gene	Chr11:88873431-88879808 (+)
BALB/cJ	MGP_BALBcJ_G0018860	protein coding gene	Chr11:86670030-86676407 (+)
C3H/HeJ	MGP_C3HHeJ_G0018674	protein coding gene	Chr11:88894035-88900406 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019312	protein coding gene	Chr11:92454823-92461205 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016943	protein coding gene	Chr11:83273466-83279854 (+)
CAST/EiJ	MGP_CASTEiJ_G0018229	protein coding gene	Chr11:89583023-89589409 (+)
CBA/J	MGP_CBAJ_G0018645	protein coding gene	Chr11:96386178-96392555 (+)
DBA/2J	MGP_DBA2J_G0018753	protein coding gene	Chr11:85816784-85823161 (+)
FVB/NJ	MGP_FVBNJ_G0018742	protein coding gene	Chr11:85314381-85320758 (+)
LP/J	MGP_LPJ_G0018823	protein coding gene	Chr11:90243936-90250313 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018769	protein coding gene	Chr11:96397439-96405025 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019352	protein coding gene	Chr11:89093873-89100243 (+)
PWK/PhJ	MGP_PWKPhJ_G0017999	protein coding gene	Chr11:86659592-86666014 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017790	protein coding gene	Chr11:88659254-88665626 (+)
WSB/EiJ	MGP_WSBEiJ_G0018278	protein coding gene	Chr11:88980479-88986846 (+)

Human Ortholog

SRSF1, serine and arginine rich splicing factor 1

Vertebrate Orthologs

10

Human Ortholog

SRSF1, serine and arginine rich splicing factor 1
Orthology source: HomoloGene, HGNC
Synonyms

ASF, SF2, SF2p33, SFRS1, SRp30a
Links

HGNC:10780

NCBI Gene ID: 6426

neXtProt AC: NX_Q07955

UniProt: Q07955
Chr Location

17q22; chr17:58000919-58007346 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 31411
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: SRSF1
Gene Tree

Srsf1

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References

1 with disease annotations

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Phenotype Summary

19 phenotypes from 2 alleles in 2 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

75
Chemically induced (other)

1
Gene trapped

68
Targeted

6
Genomic Mutations

4 involving Srsf1
Incidental Mutations

APF
Find Mice (IMSR)

63 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display early embryonic lethality. Cardiac specific conditional deletion mutants shows cardiac malfunction and premature death.

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All GO Annotations

34
GO References

16

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

694
Tissues

57
cDNA Data

23
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase srsf1

ZFIN srsf1a, srsf1b

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Srsf1 interacts with 479 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

70
RefSeq

5
UniProt

4
CCDS

CCDS36273.1, CCDS36274.1

Ensembl

ENSMUSG00000018379 (Evidence)
NCBI Gene

110809

			Length	Strain/Species	Flank
genomic	ENSMUSG00000018379	Ensembl Gene Model \| MGI Sequence Detail	6383	C57BL/6J	± kb
transcript	ENSMUST00000107920	Ensembl \| MGI Sequence Detail	1209	Not Applicable
polypeptide	ENSMUSP00000103553	Ensembl \| MGI Sequence Detail	253	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000014748 splicing factor, arginine/serine-rich 1

(term hierarchy)
PDB

1X4C
InterPro Domains

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

IPR034520 SRSF1, RNA recognition motif 1

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All nucleic 27

cDNA 25

Primer pair 1

Other 1

Microarray probesets 13

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MGD-MRK-14371, MGI:1916007, MGI:1917883, MGI:1917974, MGI:2144200, MGI:2144540

Summaries

All 76

Developmental Gene Expression 6

Diseases 1

Gene Ontology 16

Phenotypes 19
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:284098 Katsuyama T, et al., Splicing factor SRSF1 controls T cell hyperactivity and systemic autoimmunity. J Clin Invest. 2019 Dec 2;129(12):5411-5423

TSS for Srsf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104012	Chr11:88047302-88047346 (+)	-49 bp
Tssr104013	Chr11:88047660-88047690 (+)	302 bp
Tssr104014	Chr11:88047693-88047727 (+)	337 bp
Tssr104015	Chr11:88047788-88047832 (+)	437 bp
Tssr104016	Chr11:88049407-88049421 (+)	2,041 bp
Tssr104017	Chr11:88049541-88049604 (+)	2,200 bp
Tssr104018	Chr11:88051156-88051169 (+)	3,790 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 11/10/2020 MGI 6.16