Srsf1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Srsf1
serine and arginine-rich splicing factor 1
MGI:98283

19 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Myl2^tm1(cre)Krc/Myl2⁺ Srsf1^tm1Xdfu/Srsf1^tm1Xdfu involves: 129S4/SvJae	abnormal cardiac muscle contractility	J:96039
	abnormal myocardial fiber morphology	J:96039
	cardiac fibrosis	J:96039
	cardiac hypertrophy	J:96039
	decreased heart left ventricle posterior wall thickness	J:96039
	decreased heart rate	J:96039
	dilated cardiomyopathy	J:96039
	premature death	J:96039
Srsf1^tm1.1Xdfu/Srsf1^tm1.1Xdfu involves: 129S4/SvJae	embryonic lethality between implantation and somite formation, complete penetrance	J:96039
Srsf1^tm1Xdfu/Srsf1^tm1Xdfu Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 involves: 129S4/SvJae * C57BL/6 * SJL	abnormal optic nerve morphology	J:143205
	abnormal retina ganglion layer morphology	J:143205
	abnormal retina horizontal cell morphology	J:143205
	abnormal retina inner limiting membrane morphology	J:143205
	abnormal retina morphology	J:143205
	decreased amacrine cell number	J:143205
	decreased retina ganglion cell number	J:143205
	increased retina apoptosis	J:143205
	microphthalmia	J:143205
	retina degeneration	J:143205

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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