Selp
Gene Detail

Symbol Name ID

Selp selectin, platelet MGI:98280

Synonyms

CD62P, Grmp, P-selectin

Feature Type

protein coding gene

Genetic Map

Chromosome 1

71.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)

Sequence Map

Chr1:164115264-164150026 bp, + strand From VEGA annotation of GRCm38   34763 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2260  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: E-selectin/P-selectin
Gene Tree: Selp

Human homologs

Human Homolog		SELP, selectin P (granule membrane protein 140kDa, antigen CD62)
NCBI Gene ID		6403
neXtProt AC		NX_P16109
Human Synonyms		CD62, CD62P, GMP140, GRMP, LECAM3, PADGEM, PSEL
Human Chr (Location)		1q22-q25; chr1:169558087-169599377 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human SELP

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygotes for targeted null mutations exhibit mildly attenuated inflammatory responses, increased numbers of circulating neutrophils, lack of leukocyte rolling in mesenteric venules, and increased survival after Plasmodium berghei infection.

 

Gene Ontology (GO) classifications

All GO classifications: (41 annotations)

Process	blood vessel morphogenesis, cell adhesion, ...
Component	cytoplasm, external side of plasma membrane, ...
Function	calcium-dependent protein binding, carbohydrate binding, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (2)    Tissues (2)   
Theiler Stages: 20, 25

Assay Type	Results
Immunohistochemistry	2

cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) Genomic(2) cDNA(18) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000034812 (Evidence)
Ensembl Gene Model	ENSMUSG00000026580 (Evidence)
Entrez Gene	20344 (Evidence)
UniGene	3337
DFCI	TC1587977
DoTS	DT.101357586, DT.110918423, DT.530618
NIA Mouse Gene Index	U001015
Consensus CDS Project	CCDS48422.1
International Mouse Knockout Project Status	Selp

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034812	VEGA Gene Model | MGI Sequence Detail	34763	C57BL/6J
transcript	OTTMUST00000088484	VEGA | MGI Sequence Detail	3438	Not Applicable
polypeptide	OTTMUSP00000048219	VEGA | MGI Sequence Detail	768	Not Applicable

All sequences(35) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(2) : SNPs(136 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016060	Complement control module
InterPro	IPR001304	C-type lectin
InterPro	IPR018378	C-type lectin, conserved site
InterPro	IPR016187	C-type lectin fold
InterPro	IPR016186	C-type lectin-like
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR002396	Selectin superfamily
InterPro	IPR000436	Sushi/SCR/CCP
Protein Ontology	PR:000001432	P-selectin

References

(Earliest) J:4461 Popp RA, Linkage of Es-1 and Es-2 in the mouse. J Hered. 1967;58:186-188
(Latest) J:187383 Scheiermann C, et al., Adrenergic nerves govern circadian leukocyte recruitment to tissues. Immunity. 2012 Aug 24;37(2):290-301
All references(258)

Other accession IDs

MGD-MRK-10271, MGD-MRK-14360