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Selp
Gene Detail
Symbol

Name
ID
Selp
selectin, platelet
MGI:98280
Synonyms
CD62P, Grmp, P-selectin
Feature Type
protein coding gene
Genetic Map
Chromosome 1
71.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr1:164115264-164150026 bp, + strand
From VEGA annotation of GRCm38

  34763 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2260  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SELP
Protein SuperFamily: E-selectin/P-selectin
Gene Tree: Selp

Human
homologs
SELP, selectin P (granule membrane protein 140kDa, antigen CD62)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 6403
neXtProt AC: NX_P16109

Human Synonyms: CD62, CD62P, GMP140, GRMP, LECAM3, PADGEM, PSEL

Human Chr (Location): 1q24.2; chr1:169588849-169630139 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SELP

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from APF )
 
Homozygotes for targeted null mutations exhibit mildly attenuated inflammatory responses, increased numbers of circulating neutrophils, lack of leukocyte rolling in mesenteric venules, and increased survival after Plasmodium berghei infection.
 
Interactions
Selp interacts with 218 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process cell adhesion, cellular response to interleukin-6, ...
Component cytoplasm, external side of plasma membrane, ...
Function calcium-dependent protein binding, carbohydrate binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (2)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100485005    NEW 
Molecular
reagents
All nucleic(21) Genomic(2) cDNA(18) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000034812 (Evidence)
Ensembl Gene Model ENSMUSG00000026580 (Evidence)
Entrez Gene 20344 (Evidence)
UniGene 3337
DFCI TC1587977
DoTS DT.101357586, DT.110918423, DT.530618
NIA Mouse Gene Index U001015
PDB 4GXB
Consensus CDS Project CCDS48422.1
International Mouse Phenotyping Consortium Status Selp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034812 VEGA Gene Model | MGI Sequence Detail 34763 C57BL/6J ±  kb
transcript OTTMUST00000088484 VEGA | MGI Sequence Detail 3438 Not Applicable 
polypeptide OTTMUSP00000048219 VEGA | MGI Sequence Detail 768 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(270 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001304 C-type lectin
InterPro IPR018378 C-type lectin, conserved site
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR002396 Selectin superfamily
InterPro IPR000436 Sushi/SCR/CCP
Protein Ontology PR:000001432 P-selectin
References
(Earliest) J:4461 Popp RA, Linkage of Es-1 and Es-2 in the mouse. J Hered. 1967;58:186-188
(Latest) J:220789 Khoretonenko MV, et al., Platelets, acting in part via P-selectin, mediate cytomegalovirus-induced microvascular dysfunction. Am J Physiol Heart Circ Physiol. 2014 Dec 15;307(12):H1745-53
All references(267)
Other
accession IDs
MGD-MRK-10271, MGD-MRK-14360

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory