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Sell
Gene Detail
Symbol

Name
ID
Sell
selectin, lymphocyte
MGI:98279
Synonyms
CD62L, LECAM-1, Lnhr, L-selectin, Ly-22, Lyam1, Lyam-1, Ly-m22
Feature Type
protein coding gene
Genetic Map
Chromosome 1
71.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(41)
Sequence Map
Chr1:164061982-164084181 bp, + strand
From VEGA annotation of GRCm38

  22200 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:539  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: SELL
Protein SuperFamily: L-selectin
Gene Tree: Sell

Human
homologs
SELL, selectin L
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6402
neXtProt AC: NX_P14151

Human Synonyms: CD62L, LAM1, LECAM1, LEU8, LNHR, LSEL, LYAM1, PLNHR, TQ1

Human Chr (Location): 1q24.2; chr1:169690665-169711702 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(16)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit lack of lymphocyte binding to high endothelial venules of peripheral lymph nodes and defects in leukocyte rolling and neutrophil migration into the peritoneum following an inflammatory stimulus. Tumor cell survival is also reduced.
 
Human Diseases Modeled in Mice Using Sell (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Sell interacts with 173 markers (Mir1b, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cell adhesion, positive regulation of neutrophil chemotaxis, ...
Component cell surface, external side of plasma membrane, ...
Function carbohydrate binding, cell adhesion molecule binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (4)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
cDNA source data(35)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase sell    NEW 
Molecular
reagents
All nucleic(38) Genomic(3) cDNA(35)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000050837 (Evidence)
Ensembl Gene Model ENSMUSG00000026581 (Evidence)
Entrez Gene 20343 (Evidence)
UniGene 1461
DFCI TC1579302, TC1663304
DoTS DT.101359003, DT.492389
NIA Mouse Gene Index U001014
Consensus CDS Project CCDS35753.1, CCDS48421.1
International Mouse Phenotyping Consortium Status Sell
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050837 VEGA Gene Model | MGI Sequence Detail 22200 C57BL/6J ±  kb
transcript OTTMUST00000128809 VEGA | MGI Sequence Detail 1215 Not Applicable 
polypeptide OTTMUSP00000069272 VEGA | MGI Sequence Detail 387 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(10) UniProt(9)
Polymorphisms
RFLP(13) : SNPs within 2kb(204 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001304 C-type lectin
InterPro IPR018378 C-type lectin, conserved site
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
InterPro IPR013111 EGF, extracellular
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR016348 L-selectin
InterPro IPR002396 Selectin superfamily
InterPro IPR000436 Sushi/SCR/CCP
Protein Ontology PR:000001318 L-selectin
References
(Earliest) J:7544 Tada N, et al., Mouse alloantigen system Ly-m22 predominantly expressed on T lymphocytes and controlled by a gene linked to M1s region on chromosome 1. Hybridoma. 1983;2(1):29-38
(Latest) J:208214 Jakubzick C, et al., Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes. Immunity. 2013 Sep 19;39(3):599-610
All references(217)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11841, MGD-MRK-11961, MGD-MRK-12014, MGD-MRK-12052, MGD-MRK-12053, MGD-MRK-14358, MGI:2138287

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory