Sell
Gene Detail

Symbol Name ID

Sell selectin, lymphocyte MGI:98279

Synonyms

CD62L, LECAM-1, Lnhr, L-selectin, Ly-22, Lyam1, Lyam-1, Ly-m22

Feature Type

protein coding gene

Genetic Map

Chromosome 1

71.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(41)

Sequence Map

Chr1:164062076-164080785 bp, + strand From NCBI annotation of GRCm38   18710 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:539  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: L-selectin
Gene Tree: Sell

Human homologs

Human Homolog		SELL, selectin L
NCBI Gene ID		6402
neXtProt AC		NX_P14151
Human Synonyms		CD62L, LAM1, LECAM1, LEU8, LNHR, LSEL, LYAM1, PLNHR, TQ1
Human Chr (Location)		1q23-q25; chr1:169659806-169680843 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(16) : Targeted(15) Gene trapped(1)
 

Homozygotes for targeted null mutations exhibit lack of lymphocyte binding to high endothelial venules of peripheral lymph nodes and defects in leukocyte rolling and neutrophil migration into the peritoneum following an inflammatory stimulus. Tumor cell survival is also reduced.

 
Human Diseases Modeled Using Mouse Sell (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	cell adhesion, positive regulation of neutrophil chemotaxis, ...
Component	cell surface, external side of plasma membrane, ...
Function	carbohydrate binding, cell adhesion molecule binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (4)    Tissues (2)   
Theiler Stages: 26, 28

Assay Type	Results
Immunohistochemistry	4

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) Genomic(3) cDNA(14)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000026581 (Evidence)
Entrez Gene	20343 (Evidence)
DFCI	TC1579302, TC1663304
DoTS	DT.101359003, DT.492389
NIA Mouse Gene Index	U001014
Consensus CDS Project	CCDS35753.1, CCDS48421.1
International Mouse Knockout Project Status	Sell

Sequences

Length	Strain/Species
genomic	20343	NCBI Gene Model | MGI Sequence Detail	18710	C57BL/6J
transcript	NM_011346	RefSeq | MGI Sequence Detail	2341	C57BL/6
polypeptide	P18337	UniProt | EBI | MGI Sequence Detail	372	Not Applicable

All sequences(43) RefSeq(4) UniProt(8)

Polymorphisms

RFLP(13) : SNPs(121 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016060	Complement control module
InterPro	IPR001304	C-type lectin
InterPro	IPR018378	C-type lectin, conserved site
InterPro	IPR016187	C-type lectin fold
InterPro	IPR016186	C-type lectin-like
InterPro	IPR013111	EGF, extracellular
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR016348	L-selectin
InterPro	IPR002396	Selectin superfamily
InterPro	IPR000436	Sushi/SCR/CCP
Protein Ontology	PR:000001318	L-selectin

Graphical View of Protein Domain Structure

References

(Earliest) J:7544 Tada N, et al., Mouse alloantigen system Ly-m22 predominantly expressed on T lymphocytes and controlled by a gene linked to M1s region on chromosome 1. Hybridoma. 1983;2(1):29-38
(Latest) J:189559 Shenoy GN, et al., Recruitment of memory B cells to lymph nodes remote from the site of immunization requires an inflammatory stimulus. J Immunol. 2012 Jul 15;189(2):521-8
All references(207)

Other accession IDs

MGD-MRK-11841, MGD-MRK-11961, MGD-MRK-12014, MGD-MRK-12052, MGD-MRK-12053, MGD-MRK-14358, MGI:2138287