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Sell Gene Detail
Summary
  • Symbol
    Sell
  • Name
    selectin, lymphocyte
  • Synonyms
    CD62L, LECAM-1, Lnhr, L-selectin, Ly-22, Lyam1, Lyam-1, Ly-m22
  • Feature Type
    protein coding gene
  • IDs
    MGI:98279
    NCBI Gene: 20343
  • Gene Overview
    MyGene.info: SELL
Location & Maps
more
  • Sequence Map
    Chr1:164061982-164084181 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22200 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 71.37 cM
  • Mapping Data
    41 experiments
Homology
more
  • Human Ortholog
    SELL, selectin L
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SELL, selectin L
    Orthology source: HomoloGene
  • Synonyms
    CD62L, LAM1, LECAM1, LEU8, LNHR, LSEL, LYAM1, PLNHR, TQ1
  • Links
    NCBI Gene ID: 6402
    neXtProt AC: NX_P14151

  • Chr Location
    1q24.2; chr1:169690665-169711702 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Sell mouse models

Human Disease Mouse Models
       Diabetes Mellitus, Insulin-Dependent; IDDM   OMIM: 222100 View 4 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 10 alleles in 14 genetic backgrounds
    35 phenotypes from multigenic genotypes
    115 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    22
  • Chemically induced (ENU)
    2
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Targeted
    17
  • Genomic Mutations
    2 involving Sell
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit lack of lymphocyte binding to high endothelial venules of peripheral lymph nodes and defects in leukocyte rolling and neutrophil migration into the peritoneum following an inflammatory stimulus. Tumor cellsurvival is also reduced.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050837 VEGA Gene Model | MGI Sequence Detail 22200 C57BL/6J ±  kb
transcript OTTMUST00000128809 VEGA | MGI Sequence Detail 1215 Not Applicable  
polypeptide OTTMUSP00000069272 VEGA | MGI Sequence Detail 387 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    205 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 38
    Genomic 3
    cDNA 35

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-11841, MGD-MRK-11961, MGD-MRK-12014, MGD-MRK-12052, MGD-MRK-12053, MGD-MRK-14358, MGI:2138287
References
more
  • Summaries
    All 218
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 20
    Phenotypes 115
  • Earliest
    J:7544 Tada N, et al., Mouse alloantigen system Ly-m22 predominantly expressed on T lymphocytes and controlled by a gene linked to M1s region on chromosome 1. Hybridoma. 1983;2(1):29-38
  • Latest
    J:229061 Albiero M, et al., Diabetes causes bone marrow autonomic neuropathy and impairs stem cell mobilization via dysregulated p66Shc and Sirt1. Diabetes. 2014 Apr;63(4):1353-65

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory