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Sell
Gene Detail
Symbol

Name
ID
Sell
selectin, lymphocyte
MGI:98279
Synonyms
CD62L, LECAM-1, Lnhr, L-selectin, Ly-22, Lyam1, Lyam-1, Ly-m22
Feature Type
protein coding gene
Genetic Map
Chromosome 1
71.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(41)
Sequence Map
Chr1:164062076-164080785 bp, + strand
From Ensembl annotation of GRCm38

  18710 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:539  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: L-selectin
Gene Tree: Sell

Human
homologs
Human Homolog SELL, selectin L
NCBI Gene ID 6402
neXtProt AC  NX_P14151
Human Synonyms  CD62L, LAM1, LECAM1, LEU8, LNHR, LSEL, LYAM1, PLNHR, TQ1
Human Chr (Location)  1q23-q25; chr1:169690665-169711702 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(1) Targeted(15)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit lack of lymphocyte binding to high endothelial venules of peripheral lymph nodes and defects in leukocyte rolling and neutrophil migration into the peritoneum following an inflammatory stimulus. Tumor cell survival is also reduced.
 
Human Diseases Modeled Using Mouse Sell (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Sell interacts with 173 markers (Mir1b, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cell adhesion, positive regulation of neutrophil chemotaxis, ...
Component cell surface, external side of plasma membrane, ...
Function carbohydrate binding, cell adhesion molecule binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (4)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
cDNA source data(35)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(38) Genomic(3) cDNA(35)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000026581 (Evidence)
Entrez Gene20343 (Evidence)
UniGene1461
DFCITC1579302, TC1663304
DoTSDT.101359003, DT.492389
NIA Mouse Gene IndexU001014
Consensus CDS ProjectCCDS35753.1, CCDS48421.1
International Mouse Knockout Project StatusSell
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026581 Ensembl Gene Model | MGI Sequence Detail 18710 C57BL/6J ±  kb
transcript ENSMUST00000027871 Ensembl | MGI Sequence Detail 2318 Not Applicable 
polypeptide ENSMUSP00000027871 Ensembl | MGI Sequence Detail 372 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(10) UniProt(15)
Polymorphisms
RFLP(13) : SNPs within 2kb(175 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001304 C-type lectin
InterPro IPR018378 C-type lectin, conserved site
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
InterPro IPR013111 EGF, extracellular
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR016348 L-selectin
InterPro IPR002396 Selectin superfamily
InterPro IPR000436 Sushi/SCR/CCP
Protein Ontology PR:000001318 L-selectin
References
(Earliest) J:7544 Tada N, et al., Mouse alloantigen system Ly-m22 predominantly expressed on T lymphocytes and controlled by a gene linked to M1s region on chromosome 1. Hybridoma. 1983;2(1):29-38
(Latest) J:208214 Jakubzick C, et al., Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes. Immunity. 2013 Sep 19;39(3):599-610
All references(217)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11841, MGD-MRK-11961, MGD-MRK-12014, MGD-MRK-12052, MGD-MRK-12053, MGD-MRK-14358, MGI:2138287

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory