Phenotypes Associated with This Genotype

Genotype
MGI:3039428

• Allelic Composition: Sell^tm1Flv/Sell^tm1Flv
• Genetic Background: involves: C57BL/6 * NOD

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

pancreas inflammation ( J:88947 )

• inflammation of the islet of Langerhans is seen by 9 weeks in mutant and wild-type mice

immune system

pancreas inflammation ( J:88947 )

• inflammation of the islet of Langerhans is seen by 9 weeks in mutant and wild-type mice

decreased susceptibility to autoimmune disorder ( J:88947 )

• adoptive transfer experiment results with mutants backcrossed to NOD for 10 or more generations indicate that this reduction is a result of incomplete NOD genetic background

• the incidence of diabetes in these mutants is also decreased as a result of incomplete NOD genetic background

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:88974