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Ccl5
Gene Detail
Symbol

Name
ID
Ccl5
chemokine (C-C motif) ligand 5
MGI:98262
Synonyms
MuRantes, RANTES, Scya5, SISd, TCP228
Feature Type
protein coding gene
Genetic Map
Chromosome 11
50.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr11:83525778-83530518 bp, - strand
From VEGA annotation of GRCm38

  4741 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2244  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: CCL5
Protein SuperFamily: small inducible chemokine, C/CC types
Gene Tree: Ccl5

Human
homologs
CCL5, chemokine (C-C motif) ligand 5
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 6352
neXtProt AC: NX_P13501

Human Synonyms: D17S136E, eoCP, RANTES, SCYA5, SISd, SIS-delta, TCP228

Human Chr (Location): 17q12; chr17:35871491-35880373 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Genomic Mutations involving Ccl5 (1)
 
Homozygous mutation of this gene results in decreased ear and footpad swelling following injection with DHT. T cell proliferative response is also impaired in mutant mice.
 
Interactions
Ccl5 interacts with 19 markers (Mir29a, Mir138-1, Mir138-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (97 annotations)
Process activation of phospholipase D activity, calcium ion transport, ...
Component cell, cytoplasm, ...
Function CCR1 chemokine receptor binding, CCR4 chemokine receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (98)    Tissues (60)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 65
Northern blot 15
RT-PCR 18
cDNA source data(20)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100496523    NEW 
Molecular
reagents
All nucleic(26) Genomic(3) cDNA(20) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000000992 (Evidence)
Ensembl Gene Model ENSMUSG00000035042 (Evidence)
Entrez Gene 20304 (Evidence)
UniGene 284248
DFCI TC1583383
DoTS DT.490170, DT.99854861
Consensus CDS Project CCDS36254.1
International Mouse Phenotyping Consortium Status Ccl5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000992 VEGA Gene Model | MGI Sequence Detail 4741 C57BL/6J ±  kb
transcript OTTMUST00000001951 VEGA | MGI Sequence Detail 532 Not Applicable 
polypeptide OTTMUSP00000000943 VEGA | MGI Sequence Detail 91 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(29 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000827 CC chemokine, conserved site
InterPro IPR001811 Chemokine interleukin-8-like domain
Protein Ontology PR:000002094 C-C motif chemokine 5
References
(Earliest) J:17919 Schall TJ, et al., A human T cell-specific molecule is a member of a new gene family. J Immunol. 1988 Aug 1;141(3):1018-25
(Latest) J:209440 Harikumar KB, et al., K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5. Nat Immunol. 2014 Mar;15(3):231-8
All references(89)
Other
accession IDs
MGD-MRK-14336

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory