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Scn3a Gene Detail
Summary
  • Symbol
    Scn3a
  • Name
    sodium channel, voltage-gated, type III, alpha
  • Synonyms
    LOC381367, Nav1.3
  • Feature Type
    protein coding gene
  • IDs
    MGI:98249
    NCBI Gene: 20269
  • Gene Overview
    MyGene.info: SCN3A
Location & Maps
more
  • Sequence Map
    Chr2:65458263-65567627 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      109365 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 38.55 cM
  • Mapping Data
    11 experiments
Homology
more
  • Human Ortholog
    SCN3A, sodium voltage-gated channel alpha subunit 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SCN3A, sodium voltage-gated channel alpha subunit 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NAC3, Nav1.3
  • Links
    NCBI Gene ID: 6328
    neXtProt AC: NX_Q9NY46

  • Chr Location
    2q24; chr2:165087520-165204088 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 3 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (other)
    1
  • Gene trapped
    9
  • Targeted
    5
  • Genomic Mutations
    1 involving Scn3a
  • Incidental Mutations
Homozygous mutation of this gene results in lethality of most mutants by weaning. Heterozygous mice exhibit improved glucose tolerance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012887 VEGA Gene Model | MGI Sequence Detail 109365 C57BL/6J ±  kb
transcript OTTMUST00000030910 VEGA | MGI Sequence Detail 8550 Not Applicable  
polypeptide OTTMUSP00000013849 VEGA | MGI Sequence Detail 1947 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    874 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    9 Sequences
  • InterPro Domains
    IPR005821 Ion transport domain
    IPR010526 Sodium ion transport-associated
    IPR027359 Voltage-dependent channel, four helix bundle domain
    IPR024583 Voltage-gated Na+ ion channel, cytoplasmic domain
    IPR028325 Voltage-gated potassium channel
    IPR001696 Voltage gated sodium channel, alpha subunit
Molecular
Reagents
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  • All nucleic 30
    cDNA 22
    Primer pair 8

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-14322, MGI:2685846
References
more
  • Summaries
    All 46
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 12
  • Earliest
    J:11420 Malo D, et al., Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2. Genomics. 1991 Jul;10(3):666-72
  • Latest
    J:226211 Zhang Q, et al., Na+ current properties in islet alpha- and beta-cells reflect cell-specific Scn3a and Scn9a expression. J Physiol. 2014 Nov 1;592(Pt 21):4677-96

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory