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Scn3a
Gene Detail
 Symbol
Name
ID
Scn3a
sodium channel, voltage-gated, type III, alpha
MGI:98249
Synonyms LOC381367, Nav1.3
Feature Type protein coding gene
Genetic Map
Chromosome 2
38.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr2:65458263-65567627 bp, - strand
From VEGA annotation of GRCm38

  109365 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56005  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: voltage-gated sodium channel
Gene Tree: Scn3a

Human
homologs
Human Homolog SCN3A, sodium channel, voltage-gated, type III, alpha subunit
NCBI Gene ID 6328
neXtProt AC  NX_Q9NY46
Human Synonyms  NAC3, Nav1.3
Human Chr (Location)  2q24; chr2:165087520-165204088 (-)  GRCh38
Alleles
and
phenotypes
All alleles(14) : Targeted(5) Gene trapped(9)
 
Homozygous mutation of this gene results in lethality of most mutants by weaning. Heterozygous mice exhibit improved glucose tolerance.
 
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process ion transport, membrane depolarization during action potential, ...
Component cytoplasm, integral component of membrane, ...
Function potassium channel activity, sodium channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (30)    Tissues (7)   
Theiler Stages: 21, 23, 25, 28
Assay TypeResults
RT-PCR 30
cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(30) cDNA(22) Primer pair(8)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000012887 (Evidence)
Ensembl Gene ModelENSMUSG00000057182 (Evidence)
Entrez Gene20269 (Evidence)
UniGene330256
DFCITC1606576, TC1613401, TC1629296
DoTSDT.101215050, DT.101324265, DT.110705886, DT.40140165, DT.91332730, DT.91379729, DT.94154594
NIA Mouse Gene IndexU143044
Consensus CDS ProjectCCDS50596.1
International Mouse Knockout Project StatusScn3a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012887 VEGA Gene Model | MGI Sequence Detail 109365 C57BL/6J ±  kb
transcript OTTMUST00000030910 VEGA | MGI Sequence Detail 8550 Not Applicable 
polypeptide OTTMUSP00000013849 VEGA | MGI Sequence Detail 1947 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(7) UniProt(7)
Polymorphisms RFLP(1) : SNPs within 2kb(880 from dbSNP Build 137)    SNPs within 2kb including multiple locations(882)
Protein-related
information
ResourceIDDescription
InterPro IPR024583 Domain of unknown function DUF3451
InterPro IPR005821 Ion transport domain
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR010526 Sodium ion transport-associated
InterPro IPR003091 Voltage-dependent potassium channel
InterPro IPR027359 Voltage-dependent potassium channel, four helix bundle domain
InterPro IPR001696 Voltage gated sodium channel, alpha subunit
Protein Ontology PR:000002099 sodium channel type 3 subunit alpha
References (Earliest) J:11420 Malo D, et al., Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2. Genomics. 1991 Jul;10(3):666-72
(Latest) J:186617 Hao MM, et al., Early development of electrical excitability in the mouse enteric nervous system. J Neurosci. 2012 Aug 8;32(32):10949-60
All references(49)
Other
accession IDs
MGD-MRK-14322, MGI:2685846

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory