Scn3a
Gene Detail

Symbol Name ID

Scn3a sodium channel, voltage-gated, type III, alpha MGI:98249

Synonyms

LOC381367, Nav1.3

Feature Type

protein coding gene

Genetic Map

Chromosome 2

38.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr2:65458263-65567627 bp, - strand From VEGA annotation of GRCm38   109365 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56005  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: voltage-gated sodium channel
Gene Tree: Scn3a

Human homologs

Human Homolog		SCN3A, sodium channel, voltage-gated, type III, alpha subunit
NCBI Gene ID		6328
neXtProt AC		NX_Q9NY46
Human Synonyms		NAC3, Nav1.3
Human Chr (Location)		2q24; chr2:165944030-166060577 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(11) : Targeted(2) Gene trapped(9)
 

Homozygous mutation of this gene results in lethality of most mutants by weaning. Heterozygous mice exhibit improved glucose tolerance.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	ion transmembrane transport, ion transport, ...
Component	cytoplasm, integral to membrane, ...
Function	ion channel activity, potassium channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (30)    Tissues (7)   
Theiler Stages: 21, 23, 25, 28

Assay Type	Results
RT-PCR	30

cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(30) cDNA(22) Primer pair(8)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000012887 (Evidence)
Ensembl Gene Model	ENSMUSG00000057182 (Evidence)
Entrez Gene	20269 (Evidence)
UniGene	330256
DFCI	TC1606576, TC1613401, TC1629296
DoTS	DT.101215050, DT.101324265, DT.110705886, DT.40140165, DT.91332730, DT.91379729, DT.94154594
NIA Mouse Gene Index	U143044
Consensus CDS Project	CCDS50596.1
International Mouse Knockout Project Status	Scn3a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000012887	VEGA Gene Model | MGI Sequence Detail	109365	C57BL/6J
transcript	OTTMUST00000030910	VEGA | MGI Sequence Detail	8550	Not Applicable
polypeptide	OTTMUSP00000013849	VEGA | MGI Sequence Detail	1947	Not Applicable

All sequences(50) RefSeq(3) UniProt(7)

Polymorphisms

RFLP(1) : SNPs(601 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR024583	Domain of unknown function DUF3451
InterPro	IPR005821	Ion transport domain
InterPro	IPR000048	IQ motif, EF-hand binding site
InterPro	IPR010526	Sodium ion transport-associated
InterPro	IPR003091	Voltage-dependent potassium channel
InterPro	IPR001696	Voltage gated sodium channel, alpha subunit
Protein Ontology	PR:000002099	sodium channel type 3 subunit alpha

References

(Earliest) J:11420 Malo D, et al., Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2. Genomics. 1991 Jul;10(3):666-72
(Latest) J:186617 Hao MM, et al., Early development of electrical excitability in the mouse enteric nervous system. J Neurosci. 2012 Aug 8;32(32):10949-60
All references(46)

Other accession IDs

MGD-MRK-14322, MGI:2685846