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S100b
Gene Detail
Symbol

Name
ID
S100b
S100 protein, beta polypeptide, neural
MGI:98217
Feature Type
protein coding gene
Genetic Map
Chromosome 10
38.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr10:76253853-76261159 bp, + strand
From VEGA annotation of GRCm38

  7307 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4567  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: S100B
Protein SuperFamily: S-100 protein
Gene Tree: S100b

Human
homologs
S100B, S100 calcium binding protein B
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6285
neXtProt AC: NX_P04271

Human Synonyms: NEF, S100, S100-B, S100beta

Human Chr (Location): 21q22.3; chr21:46598618-46605122 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(1) Targeted(8) Transgenic(1)
Genomic Mutations involving S100b (4)
 
Homozygotes for targeted null mutations exhibit enhanced spatial memory, fear memory, and long-term potentiation in the hippocampal CA1 region, and more rapid and severe seizures as the result of an amygdala kindling paradigm.
 
Mutations Annotated to Human Diseases (1)   
Interactions
S100b interacts with 136 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process cellular calcium ion homeostasis, energy reserve metabolic process, ...
Component cytoplasm, extracellular region, ...
Function calcium-dependent protein binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (128 records)
Data Summary: Results (180)    Tissues (142)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 140
Western blot 17
RT-PCR 18
cDNA source data(20)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(43) Genomic(17) cDNA(23) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000020277 (Evidence)
Ensembl Gene Model ENSMUSG00000033208 (Evidence)
Entrez Gene 20203 (Evidence)
UniGene 235998
DFCI TC1584777, TC1605408, TC1608299, TC1678232
DoTS DT.487795, DT.94281710
NIA Mouse Gene Index U011674
Consensus CDS Project CCDS35943.1
International Mouse Phenotyping Consortium Status S100b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020277 VEGA Gene Model | MGI Sequence Detail 7307 C57BL/6J ±  kb
transcript OTTMUST00000048129 VEGA | MGI Sequence Detail 1484 Not Applicable 
polypeptide OTTMUSP00000021974 VEGA | MGI Sequence Detail 92 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(4) : SNPs within 2kb(84 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR013787 S100/CaBP-9k-type, calcium binding, subdomain
InterPro IPR001751 S100/Calbindin-D9k, conserved site
Protein Ontology PR:000014419 protein S100-B
References
(Earliest) J:12130 MacDonald GP, et al., Assignment of four human chromosome 21 genes to mouse chromosome 10: Implications for mouse models of Down Syndrome. Am J Hum Genet. 1988;43:A151 (Abstr.)
(Latest) J:222255 Knock E, et al., The methyl binding domain 3/nucleosome remodelling and deacetylase complex regulates neural cell fate determination and terminal differentiation in the cerebral cortex. Neural Dev. 2015;10:13
All references(210)
Other
accession IDs
MGD-MRK-14269, MGI:2143688

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory