S100b
Gene Detail

Symbol Name ID

S100b S100 protein, beta polypeptide, neural MGI:98217

Feature Type

protein coding gene

Genetic Map

Chromosome 10

38.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)

Sequence Map

Chr10:76253853-76261159 bp, + strand From VEGA annotation of GRCm38   7307 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4567  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: S-100 protein
Gene Tree: S100b

Human homologs

Human Homolog		S100B, S100 calcium binding protein B
NCBI Gene ID		6285
neXtProt AC		NX_P04271
Human Synonyms		NEF, S100, S100-B, S100beta
Human Chr (Location)		21q22.3; chr21:48018531-48025035 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Homozygotes for targeted null mutations exhibit enhanced spatial memory, fear memory, and long-term potentiation in the hippocampal CA1 region, and more rapid and severe seizures as the result of an amygdala kindling paradigm.

 

Gene Ontology (GO) classifications

All GO classifications: (36 annotations)

Process	cellular calcium ion homeostasis, energy reserve metabolic process, ...
Component	cytoplasm, extracellular region, ...
Function	calcium-dependent protein binding, calcium ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (98 records)
Data Summary: Results (160)    Tissues (132)    Images (23)
Theiler Stages: 13, 15, 17, 19, 20, 22, 23, 26, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	140
RT-PCR	18

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(43) Genomic(17) cDNA(23) Primer pair(2) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000020277 (Evidence)
Ensembl Gene Model	ENSMUSG00000033208 (Evidence)
Entrez Gene	20203 (Evidence)
UniGene	235998
DFCI	TC1584777, TC1605408, TC1608299, TC1678232
DoTS	DT.487795, DT.94281710
NIA Mouse Gene Index	U011674
Consensus CDS Project	CCDS35943.1
International Mouse Knockout Project Status	S100b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020277	VEGA Gene Model | MGI Sequence Detail	7307	C57BL/6J
transcript	OTTMUST00000048129	VEGA | MGI Sequence Detail	1484	Not Applicable
polypeptide	OTTMUSP00000021974	VEGA | MGI Sequence Detail	92	Not Applicable

All sequences(29) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(4) : SNPs(77 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR018247	EF-Hand 1, calcium-binding site
InterPro	IPR018249	EF-HAND 2
InterPro	IPR011992	EF-hand-like domain
InterPro	IPR013787	S100/CaBP-9k-type, calcium binding, subdomain
InterPro	IPR001751	S100/Calbindin-D9k, conserved site
Protein Ontology	PR:000014419	protein S100-B

References

(Earliest) J:12130 MacDonald GP, et al., Assignment of four human chromosome 21 genes to mouse chromosome 10: Implications for mouse models of Down Syndrome. Am J Hum Genet. 1988;43:A151 (Abstr.)
(Latest) J:194894 Couesnon A, et al., CLIPR-59: a protein essential for neuromuscular junction stability during mouse late embryonic development. Development. 2013 Apr;140(7):1583-93
All references(184)

Other accession IDs

MGD-MRK-14269, MGI:2143688