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Rrm2 Gene Detail
Summary
  • Symbol
    Rrm2
  • Name
    ribonucleotide reductase M2
  • Synonyms
    R2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98181
    NCBI Gene: 20135
Location & Maps
more
  • Sequence Map
    Chr12:24708241-24714146 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5906 bp   ±  kb flank

  • Genome Browsers
Homology
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  • Human Ortholog
    RRM2, ribonucleotide reductase regulatory subunit M2
  • Vertebrate Orthologs
    12
  • Human Ortholog
    RRM2, ribonucleotide reductase regulatory subunit M2
    Orthology source: HomoloGene
  • Synonyms
    R2, RR2, RR2M
  • Links
    NCBI Gene ID: 6241
    neXtProt AC: NX_P31350

  • Chr Location
    2p25-p24; chr2:10122568-10131419 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 20277
    1 human;1 mouse;2 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: RRM2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    5
  • Gene trapped
    1
  • Targeted
    3
  • Transgenic
    1
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027512 VEGA Gene Model | MGI Sequence Detail 5906 C57BL/6J ±  kb
transcript OTTMUST00000068102 VEGA | MGI Sequence Detail 2193 Not Applicable  
polypeptide OTTMUSP00000034365 VEGA | MGI Sequence Detail 390 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    142 from dbSNP Build 137
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    Genomic 3
    cDNA 21
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-14210, MGI:2145142
References
more
  • Summaries
    All 51
    Developmental Gene Expression 6
    Gene Ontology 11
    Phenotypes 8
  • Earliest
    J:8879 Yang-Feng TL, et al., Ribonucleotide reductase M2 subunit sequences mapped to four different chromosomal sites in humans and mice: functional locus identified by its amplification in hydroxyurea-resistant cell lines. Genomics. 1987 Sep;1(1):77-86
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory