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Rrm2
Gene Detail
 Symbol
Name
ID
Rrm2
ribonucleotide reductase M2
MGI:98181
Synonyms R2
Feature Type protein coding gene
Genetic Map
Chromosome 12
8.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(21)
Sequence Map
Chr12:24708241-24714146 bp, + strand
From VEGA annotation of GRCm38

  5906 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20277  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Rrm2

Human
homologs
Human Homolog RRM2, ribonucleotide reductase M2
NCBI Gene ID 6241
neXtProt AC  NX_P31350
Human Synonyms  R2, RR2, RR2M
Human Chr (Location)  2p25-p24; chr2:10122568-10131419 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Interactions
Rrm2 interacts with 164 markers (Mir17, Mir18, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process deoxyribonucleoside diphosphate metabolic process, deoxyribonucleotide biosynthetic process, ...
Component cytoplasm, nuclear envelope, ...
Function metal ion binding, oxidoreductase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (282)    Tissues (114)    Images (36)
Theiler Stages: 20, 22, 23, 24
Assay TypeResults
RNA in situ 282
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) Genomic(3) cDNA(21) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000027512 (Evidence)
Ensembl Gene ModelENSMUSG00000020649 (Evidence)
Entrez Gene20135 (Evidence)
DFCITC1573327, TC1617377, TC1629239
DoTSDT.101391645, DT.101711839, DT.495536, DT.94201692
NIA Mouse Gene IndexU013803, U033845
EC1.17.4.1
PDB1AFT, 1H0N, 1H0O, 1XSM, 1W68, 1W69
Consensus CDS ProjectCCDS25844.1
International Mouse Knockout Project StatusRrm2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027512 VEGA Gene Model | MGI Sequence Detail 5906 C57BL/6J ±  kb
transcript OTTMUST00000068102 VEGA | MGI Sequence Detail 2193 Not Applicable 
polypeptide OTTMUSP00000034365 VEGA | MGI Sequence Detail 390 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(2) UniProt(4)
Polymorphisms RFLP(2) : SNPs within 2kb(142 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009078 Ferritin-like superfamily
InterPro IPR012348 Ribonucleotide reductase-related
InterPro IPR000358 Ribonucleotide reductase small subunit
Protein Ontology PR:000014306 ribonucleoside-diphosphate reductase subunit M2
References (Earliest) J:8879 Yang-Feng TL, et al., Ribonucleotide reductase M2 subunit sequences mapped to four different chromosomal sites in humans and mice: functional locus identified by its amplification in hydroxyurea-resistant cell lines. Genomics. 1987 Sep;1(1):77-86
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(58)
Other
accession IDs
MGD-MRK-14210, MGI:2145142

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory