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Rrm2 Gene Detail
Summary
  • Symbol
    Rrm2
  • Name
    ribonucleotide reductase M2
  • Synonyms
    R2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98181
    NCBI Gene: 20135
  • Gene Overview
    MyGene.info: RRM2
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:24708254-24714146 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 8.50 cM
  • Mapping Data
    22 experiments
Strain
Comparison
more
  • SNPs within 2kb
    141 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98181
protein coding gene Chr12:24708241-24714146 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019632
protein coding gene Chr12:22389167-22395075 (+)
A/J MGP_AJ_G0019599
protein coding gene Chr12:21776770-21782885 (+)
AKR/J MGP_AKRJ_G0019570
protein coding gene Chr12:22505881-22513591 (+)
BALB/cJ MGP_BALBcJ_G0019576
protein coding gene Chr12:22045446-22051340 (+)
C3H/HeJ MGP_C3HHeJ_G0019380
protein coding gene Chr12:22385283-22391191 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020024
protein coding gene Chr12:23078505-23084410 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017648
protein coding gene Chr12:21259337-21264846 (+)
CAST/EiJ MGP_CASTEiJ_G0018935
protein coding gene Chr12:17350070-17356092 (+)
CBA/J MGP_CBAJ_G0019351
protein coding gene Chr12:23814061-23819969 (+)
DBA/2J MGP_DBA2J_G0019465
protein coding gene Chr12:21627851-21635086 (+)
FVB/NJ MGP_FVBNJ_G0019456
protein coding gene Chr12:21519427-21525306 (+)
LP/J MGP_LPJ_G0019535
protein coding gene Chr12:22455897-22462819 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019491
protein coding gene Chr12:23671433-23677556 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020063
protein coding gene Chr12:22071929-22077837 (+)
PWK/PhJ MGP_PWKPhJ_G0018702
protein coding gene Chr12:16361624-16367816 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018490
protein coding gene Chr12:16579246-16586070 (+)
WSB/EiJ MGP_WSBEiJ_G0018986
protein coding gene Chr12:22222115-22228716 (+)



Homology
more
  • Human Ortholog
    RRM2, ribonucleotide reductase regulatory subunit M2
  • Vertebrate Orthologs
    12
  • Human Ortholog
    RRM2, ribonucleotide reductase regulatory subunit M2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    R2, RR2, RR2M
  • Links
    NCBI Gene ID: 6241
    neXtProt AC: NX_P31350
    UniProt: P31350

  • Chr Location
    2p25.1; chr2:10122568-10131419 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 20277
    1 human;1 mouse;2 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RRM2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20135 NCBI Gene Model | MGI Sequence Detail 5893 C57BL/6J ±  kb
transcript NM_009104 RefSeq | MGI Sequence Detail 2199 C57BL/6  
polypeptide P11157 UniProt | EBI | MGI Sequence Detail 390 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    Genomic 3
    cDNA 22
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-14210, MGI:2145142
References
more
  • Summaries
    All 74
    Developmental Gene Expression 9
    Gene Ontology 14
    Phenotypes 12
  • Earliest
    J:8537 Thelander L, et al., Isolation and characterization of expressible cDNA clones encoding the M1 and M2 subunits of mouse ribonucleotide reductase. Mol Cell Biol. 1986 Oct;6(10):3433-42
  • Latest
    J:241850 Naiman N, et al., Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development. Dev Cell. 2017 May 22;41(4):349-365.e3

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory