Rlbp1
Gene Detail

Symbol Name ID

Rlbp1 retinaldehyde binding protein 1 MGI:97930

Synonyms

3110056M11Rik, CRALBP

Feature Type

protein coding gene

Genetic Map

Chromosome 7

45.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr7:79374871-79387027 bp, - strand From Ensembl annotation of GRCm38   12157 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68046  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: cellular retinaldehyde-binding protein
Gene Tree: Rlbp1

Human homologs

Human Homolog		RLBP1, retinaldehyde binding protein 1
NCBI Gene ID		6017
neXtProt AC		NX_P12271
Human Synonyms		CRALBP
Human Chr (Location)		15q26; chr15:89753098-89764922 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human RLBP1

Alleles and phenotypes

All alleles(9) : Targeted(4) Gene trapped(5)
 

Mice homozygous for disruptions in this gene display delayed dark adaptation as well as reduced retinal degeneration.

 
Human Diseases Modeled Using Mouse Rlbp1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	response to stimulus, transport, ...
Component	cell body, cytoplasm, ...
Function	11-cis retinal binding, retinol binding, ...

External Resources: FuncBase

Expression

Literature Summary: (26 records)
Data Summary: Results (84)    Tissues (19)    Images (18)
Theiler Stages: 20, 23, 24, 28

Assay Type	Results
RNA in situ	84

cDNA source data(30)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(32) cDNA(31) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000039194 (Evidence)
Entrez Gene	19771 (Evidence)
UniGene	41653
DFCI	TC1579657
DoTS	DT.101362355, DT.97359844
NIA Mouse Gene Index	U028741
Consensus CDS Project	CCDS39990.1
International Mouse Knockout Project Status	Rlbp1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000039194	Ensembl Gene Model | MGI Sequence Detail	12157	C57BL/6J
transcript	ENSMUST00000053718	Ensembl | MGI Sequence Detail	2202	Not Applicable
polypeptide	ENSMUSP00000054545	Ensembl | MGI Sequence Detail	317	Not Applicable

All sequences(25) RefSeq(4) UniProt(2)

Polymorphisms

SNPs(71 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001071	Cellular retinaldehyde binding/alpha-tocopherol transport
InterPro	IPR001251	CRAL-TRIO domain
InterPro	IPR011074	CRAL/TRIO, N-terminal domain
Protein Ontology	PR:000014030	retinaldehyde-binding protein 1

References

(Earliest) J:6901 Saari JC, et al., Identification of the endogenous retinoids associated with three cellular retinoid-binding proteins from bovine retina and retinal pigment epithelium. J Biol Chem. 1982 Nov 25;257(22):13329-33
(Latest) J:180331 Boppana S, et al., Cellular retinaldehyde-binding protein (CRALBP) is a direct downstream target of transcription factor Pax6. Biochim Biophys Acta. 2012 Feb;1820(2):151-6
All references(58)

Other accession IDs

MGD-MRK-13896, MGI:1920482