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Rlbp1
Gene Detail
Symbol

Name
ID
Rlbp1
retinaldehyde binding protein 1
MGI:97930
Synonyms
3110056M11Rik, CRALBP
Feature Type
protein coding gene
Genetic Map
Chromosome 7
45.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:79374871-79387027 bp, - strand
From Ensembl annotation of GRCm38

  12157 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68046  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: RLBP1
Protein SuperFamily: cellular retinaldehyde-binding protein
Gene Tree: Rlbp1

Human
homologs
RLBP1, retinaldehyde binding protein 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6017
neXtProt AC: NX_P12271

Human Synonyms: CRALBP

Human Chr (Location): 15q26; chr15:89209867-89221909 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human RLBP1

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(5) Targeted(5)
 
Mice homozygous for disruptions in this gene display delayed dark adaptation as well as reduced retinal degeneration.
 
Human Diseases Modeled in Mice Using Rlbp1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Rlbp1 interacts with 92 markers (Mir7-1, Mir18, Mir18b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process response to stimulus, transport, ...
Component cell body, cytoplasm, ...
Function 11-cis retinal binding, retinol binding, ...
External Resources: FuncBase
Expression
Literature Summary: (29 records)
Data Summary: Results (101)    Tissues (30)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 7
RNA in situ 94
cDNA source data(30)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase rlbp1 ; ZFIN rlbp1a, rlbp1b    NEW 
Molecular
reagents
All nucleic(33) cDNA(31) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000039194 (Evidence)
Entrez Gene 19771 (Evidence)
UniGene 41653
DFCI TC1579657
DoTS DT.101362355, DT.97359844
NIA Mouse Gene Index U028741
Consensus CDS Project CCDS39990.1
International Mouse Phenotyping Consortium Status Rlbp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039194 Ensembl Gene Model | MGI Sequence Detail 12157 C57BL/6J ±  kb
transcript ENSMUST00000053718 Ensembl | MGI Sequence Detail 2202 Not Applicable 
polypeptide ENSMUSP00000054545 Ensembl | MGI Sequence Detail 317 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(12) UniProt(2)
Polymorphisms
SNPs within 2kb(104 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001071 Cellular retinaldehyde binding/alpha-tocopherol transport
InterPro IPR001251 CRAL-TRIO domain
InterPro IPR011074 CRAL/TRIO, N-terminal domain
Protein Ontology PR:000014030 retinaldehyde-binding protein 1
References
(Earliest) J:6901 Saari JC, et al., Identification of the endogenous retinoids associated with three cellular retinoid-binding proteins from bovine retina and retinal pigment epithelium. J Biol Chem. 1982 Nov 25;257(22):13329-33
(Latest) J:220383 Xue Y, et al., CRALBP supports the mammalian retinal visual cycle and cone vision. J Clin Invest. 2015 Feb;125(2):727-38
All references(64)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-13896, MGI:1920482

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory