Rlbp1^tm1Jsa
Targeted Allele Detail

Summary

• Symbol: Rlbp1^tm1Jsa
• Name: retinaldehyde binding protein 1; targeted mutation 1, John C Saari
• MGI ID: MGI:2181491
• Synonyms: Rlbp1^-
• Gene: Rlbp1 Location: Chr7:79024618-79036796 bp, - strand Genetic Position: Chr7, 45.0 cM
• Alliance: Rlbp1^tm1Jsa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68444
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette into exon 3 via homologous recombination. Absence of gene expression in retinas of homozygous mutant mice was demonstrated by immunohistochemistry and Western blot analysis. (J:68444)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rlbp1 Mutation: 29 strains or lines available

References

• Original: J:68444 Saari JC, et al., Visual cycle impairment in cellular retinaldehyde binding protein (CRALBP) knockout mice results in delayed dark adaptation. Neuron. 2001 Mar;29(3):739-48
• All: 6 reference(s)