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Rheb
Gene Detail
Symbol

Name
ID
Rheb
Ras homolog enriched in brain
MGI:97912
Synonyms
Rheb1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
11.93 cM
Detailed Genetic Map ± 1 cM

Sequence Map
Chr5:24802823-24842624 bp, - strand
From VEGA annotation of GRCm38

  39802 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:123916  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RHEB
Protein SuperFamily: Ras-related protein Rab
Gene Tree: Rheb

Human
homologs
RHEB, Ras homolog enriched in brain
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6009
neXtProt AC: NX_Q15382

Human Synonyms: RHEB2

Human Chr (Location): 7q36; chr7:151466012-151519924 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(36) : Gene trapped(28) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele display embryonic lethality during organogenesis associated with impaired heart development. Mice homozygous for a conditional allele activated in the heart exhibit postnatal lethality due to impaired cardiac hypertrophic growth and sarcomere maturation.
 
Phenotype Images(1)
Interactions
Rheb interacts with 218 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process positive regulation of oligodendrocyte differentiation, positive regulation of TOR signaling, ...
Component cytoplasm, dendrite, ...
Function GDP binding, GTPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (62)    Tissues (36)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 62
cDNA source data(132)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rheb    NEW 
Molecular
reagents
All nucleic(132) cDNA(132)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000023527 (Evidence)
Ensembl Gene Model ENSMUSG00000028945 (Evidence)
Entrez Gene 19744 (Evidence)
UniGene 319175
DFCI TC1574556, TC1671617
DoTS DT.494722, DT.97331925
NIA Mouse Gene Index U026006
PDB 4O2L, 4O2R, 4O25
Consensus CDS Project CCDS39032.1
International Mouse Phenotyping Consortium Status Rheb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023527 VEGA Gene Model | MGI Sequence Detail 39802 C57BL/6J ±  kb
transcript OTTMUST00000057340 VEGA | MGI Sequence Detail 1784 Not Applicable 
polypeptide OTTMUSP00000027651 VEGA | MGI Sequence Detail 184 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(367 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR020849 Small GTPase superfamily, Ras type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000013975 GTP-binding protein Rheb
References
(Earliest) J:71817 Sutherland HG, et al., Large-scale identification of mammalian proteins localized to nuclear sub-compartments. Hum Mol Genet. 2001 Sep 1;10(18):1995-2011
(Latest) J:221351 Goorden SM, et al., Intact neuronal function in Rheb1 mutant mice: implications for TORC1-based treatments. Hum Mol Genet. 2015 Jun 15;24(12):3390-8
All references(55)
Other
accession IDs
MGD-MRK-13864

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory