Rheb
Gene Detail

Symbol Name ID

Rheb Ras homolog enriched in brain MGI:97912

Feature Type

protein coding gene

Genetic Map

Chromosome 5

11.93 cM
Detailed Genetic Map ± 1 cM

Sequence Map

Chr5:24802823-24842624 bp, - strand From VEGA annotation of GRCm38   39802 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:123916  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Ras-related protein Rab
Gene Tree: Rheb

Human homologs

Human Homolog		RHEB, Ras homolog enriched in brain
NCBI Gene ID		6009
neXtProt AC		NX_Q15382
Human Synonyms		RHEB2
Human Chr (Location)		7q36; chr7:151163098-151217010 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(33) : Targeted(5) Gene trapped(28)
 

Mice homozygous for a null allele display embryonic lethality during organogenesis associated with impaired heart development.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	GTP catabolic process, positive regulation of TOR signaling cascade, ...
Component	membrane, plasma membrane, ...
Function	GTP binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (62)    Tissues (36)    Images (27)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	62

cDNA source data(124)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(124) cDNA(124)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000023527 (Evidence)
Ensembl Gene Model	ENSMUSG00000028945 (Evidence)
Entrez Gene	19744 (Evidence)
UniGene	319175
DFCI	TC1574556, TC1671617
DoTS	DT.494722, DT.97331925
NIA Mouse Gene Index	U026006
Consensus CDS Project	CCDS39032.1
International Mouse Knockout Project Status	Rheb

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023527	VEGA Gene Model | MGI Sequence Detail	39802	C57BL/6J
transcript	OTTMUST00000057340	VEGA | MGI Sequence Detail	1784	Not Applicable
polypeptide	OTTMUSP00000027651	VEGA | MGI Sequence Detail	184	Not Applicable

All sequences(26) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(269 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001806	Small GTPase superfamily
InterPro	IPR020849	Small GTPase superfamily, Ras type
InterPro	IPR005225	Small GTP-binding protein domain
Protein Ontology	PR:000013975	GTP-binding protein Rheb

References

(Earliest) J:71817 Sutherland HG, et al., Large-scale identification of mammalian proteins localized to nuclear sub-compartments. Hum Mol Genet. 2001 Sep 1;10(18):1995-2011
(Latest) J:180541 Zheng M, et al., Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1. Nat Cell Biol. 2011 Mar;13(3):263-72
All references(48)

Other accession IDs

MGD-MRK-13864