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Rfc1 Gene Detail
Summary
  • Symbol
    Rfc1
  • Name
    replication factor C (activator 1) 1
  • Synonyms
    140kDa, Alp145, Recc1, RFC140
  • Feature Type
    protein coding gene
  • IDs
    MGI:97891
    NCBI Gene: 19687
  • Gene Overview
    MyGene.info: RFC1
Location & Maps
more
  • Sequence Map
    Chr5:65261850-65335670 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      73821 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 33.61 cM, cytoband C
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    RFC1, replication factor C subunit 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RFC1, replication factor C subunit 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    A1, MHCBFB, PO-GA, RECC1, RFC, RFC140
  • Links
    NCBI Gene ID: 5981
    neXtProt AC: NX_P35251

  • Chr Location
    4p14-p13; chr4:39287449-39366381 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    48
  • Chemically induced (other)
    2
  • Gene trapped
    41
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    4 involving Rfc1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000038036 VEGA Gene Model | MGI Sequence Detail 73821 C57BL/6J ±  kb
transcript OTTMUST00000097963 VEGA | MGI Sequence Detail 4689 Not Applicable  
polypeptide OTTMUSP00000054967 VEGA | MGI Sequence Detail 1145 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    332 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    12 Sequences
  • Protein Ontology
    PR:000013905 replication factor C subunit 1
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR003959 ATPase, AAA-type, core
    IPR001357 BRCT domain
    IPR008921 DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal
    IPR013725 DNA replication factor RFC1, C-terminal
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR012178 Replication factor C subunit 1
Molecular
Reagents
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  • All nucleic 188
    cDNA 187
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-13825
References
more
  • Summaries
    All 51
    Developmental Gene Expression 8
    Gene Ontology 6
    Phenotypes 26
  • Earliest
    J:28599 Burbelo PD, et al., Cloning of the large subunit of activator 1 (replication factor C) reveals homology with bacterial DNA ligases. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11543-7
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory