Rdx
Gene Detail

Symbol Name ID

Rdx radixin MGI:97887

Feature Type

protein coding gene

Genetic Map

Chromosome 9

28.62 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr9:52047150-52088737 bp, + strand From Ensembl annotation of GRCm38   41588 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37707  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ezrin/radixin/moesin
Gene Tree: Rdx

Human homologs

Human Homolog		RDX, radixin
NCBI Gene ID		5962
neXtProt AC		NX_P35241
Human Synonyms		DFNB24
Human Chr (Location)		11q23; chr11:110045605-110167437 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human RDX

Alleles and phenotypes

All alleles(31) : Targeted(4) Gene trapped(27)
 

Mice homozygous for a targeted mutation display mild degenerative changes in the liver and hyperbilirubinemia. Adult homozygotes exhibit profound deafness, but not imbalance, associated with progressive degeneration of stereocilia of cochlear hair cells after the onset of hearing.

 
Human Diseases Modeled Using Mouse Rdx (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (29 annotations)

Process	actin filament capping, apical protein localization, ...
Component	apical part of cell, cell-cell adherens junction, ...
Function	actin binding, cytoskeletal protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (9)    Tissues (5)    Images (2)
Theiler Stages: 13, 22, 28

Assay Type	Results
Immunohistochemistry	6
RNA in situ	3

cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) cDNA(17)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000032050 (Evidence)
Entrez Gene	19684 (Evidence)
DFCI	TC1573146, TC1586795, TC1601522, TC1619650, TC1627343
DoTS	DT.101248412, DT.101392230, DT.110599334, DT.493912, DT.91342930, DT.94132974, DT.97415609
PDB	2D2Q, 2EMS, 2EMT, 2YVC, 2ZPY, 1GC6, 1GC7, 1J19, 2D10, 2D11
Consensus CDS Project	CCDS40634.1, CCDS52793.1
International Mouse Knockout Project Status	Rdx

Sequences

Length	Strain/Species
genomic	ENSMUSG00000032050	Ensembl Gene Model | MGI Sequence Detail	41588	C57BL/6J
transcript	ENSMUST00000163153	Ensembl | MGI Sequence Detail	4156	Not Applicable
polypeptide	ENSMUSP00000128249	Ensembl | MGI Sequence Detail	583	Not Applicable

All sequences(60) RefSeq(6) UniProt(8)

Polymorphisms

SNPs(170 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR019749	Band 4.1 domain
InterPro	IPR019750	Band 4.1 family
InterPro	IPR011174	Ezrin/radixin/moesin
InterPro	IPR011259	Ezrin/radixin/moesin, C-terminal
InterPro	IPR000798	Ezrin/radixin/moesin like
InterPro	IPR014352	FERM/acyl-CoA-binding protein, 3-helical bundle
InterPro	IPR019748	FERM central domain
InterPro	IPR019747	FERM conserved site
InterPro	IPR018980	FERM, C-terminal PH-like domain
InterPro	IPR000299	FERM domain
InterPro	IPR018979	FERM, N-terminal
InterPro	IPR008954	Moesin
InterPro	IPR011993	Pleckstrin homology-like domain
Protein Ontology	PR:000003009	radixin

References

(Earliest) J:35128 Funayama N, et al., Radixin is a novel member of the band 4.1 family. J Cell Biol. 1991 Nov;115(4):1039-48
(Latest) J:178461 Pearson HB, et al., SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia. J Clin Invest. 2011 Nov 1;121(11):4257-67
All references(61)

Other accession IDs

MGD-MRK-13819, MGI:2142943