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Rdx Gene Detail
Summary
  • Symbol
    Rdx
  • Name
    radixin
  • Feature Type
    protein coding gene
  • IDs
    MGI:97887
    NCBI Gene: 19684
  • Gene Overview
    MyGene.info: RDX
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:52047173-52088735 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 28.62 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    192 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97887
protein coding gene Chr9:52047150-52088738 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034804
protein coding gene Chr9:51021648-51063885 (+)
A/J MGP_AJ_G0034785
protein coding gene Chr9:49431072-49473816 (+)
AKR/J MGP_AKRJ_G0034713
protein coding gene Chr9:50478936-50520441 (+)
BALB/cJ MGP_BALBcJ_G0034777
protein coding gene Chr9:49187625-49229583 (+)
C3H/HeJ MGP_C3HHeJ_G0034487
protein coding gene Chr9:50978164-51019653 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035296
protein coding gene Chr9:52433720-52477586 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032209
protein coding gene Chr9:48871401-48913058 (+)
CAST/EiJ MGP_CASTEiJ_G0033809
protein coding gene Chr9:50936059-50980022 (+)
CBA/J MGP_CBAJ_G0034458
protein coding gene Chr9:54253514-54294973 (+)
DBA/2J MGP_DBA2J_G0034617
protein coding gene Chr9:49288694-49330733 (+)
FVB/NJ MGP_FVBNJ_G0034559
protein coding gene Chr9:48503064-48545519 (+)
LP/J MGP_LPJ_G0034699
protein coding gene Chr9:51349191-51391862 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034602
protein coding gene Chr9:55849863-55891925 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035318
protein coding gene Chr9:50475969-50517425 (+)
PWK/PhJ MGP_PWKPhJ_G0033513
protein coding gene Chr9:49279558-49321826 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033349
protein coding gene Chr9:50758475-50800650 (+)
WSB/EiJ MGP_WSBEiJ_G0033921
protein coding gene Chr9:50474927-50517398 (+)



Homology
more
  • Human Ortholog
    RDX, radixin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RDX, radixin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DFNB24
  • Links
    NCBI Gene ID: 5962
    neXtProt AC: NX_P35241
    UniProt: P35241

  • Chr Location
    11q22.3; chr11:110174880-110296712 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Rdx mouse models; 1 with human RDX associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    3 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation display mild degenerative changes in the liver and hyperbilirubinemia. Adult homozygotes exhibit profound deafness, but not imbalance, associated with progressive degeneration of stereocilia of cochlear hair cells after the onset of hearing.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032050 Ensembl Gene Model | MGI Sequence Detail 41563 C57BL/6J ±  kb
    transcript ENSMUST00000163153 Ensembl | MGI Sequence Detail 4131 Not Applicable  
    polypeptide ENSMUSP00000128249 Ensembl | MGI Sequence Detail 583 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 18

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-13819, MGI:2142943
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 14
      Diseases 1
      Gene Ontology 17
      Phenotypes 17
    • Earliest
      J:35128 Funayama N, et al., Radixin is a novel member of the band 4.1 family. J Cell Biol. 1991 Nov;115(4):1039-48
    • Latest
      J:258787 Bresson L, et al., Podoplanin regulates mammary stem cell function and tumorigenesis by potentiating Wnt/beta-catenin signaling. Development. 2018 Feb 21;145(4)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory