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Rdx
Gene Detail
Symbol

Name
ID
Rdx
radixin
MGI:97887
Feature Type
protein coding gene
Genetic Map
Chromosome 9
28.62 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:52047150-52088737 bp, + strand
From Ensembl annotation of GRCm38

  41588 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37707  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: ezrin/radixin/moesin
Gene Tree: Rdx

Human
homologs
Human Homolog RDX, radixin
NCBI Gene ID 5962
neXtProt AC  NX_P35241
Human Synonyms  DFNB24
Human Chr (Location)  11q23; chr11:110174880-110296712 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human RDX
Mutations,
alleles, and
phenotypes
All mutations/alleles(31) : Gene trapped(27) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation display mild degenerative changes in the liver and hyperbilirubinemia. Adult homozygotes exhibit profound deafness, but not imbalance, associated with progressive degeneration of stereocilia of cochlear hair cells after the onset of hearing.
 
Human Diseases Modeled Using Mouse Rdx (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Interactions
Rdx interacts with 332 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process actin filament capping, apical protein localization, ...
Component apical part of cell, cell-cell adherens junction, ...
Function actin binding, cytoskeletal protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (9)    Tissues (5)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 3
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(17)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000032050 (Evidence)
Entrez Gene19684 (Evidence)
DFCITC1573146, TC1586795, TC1601522, TC1619650, TC1627343
DoTSDT.101248412, DT.101392230, DT.110599334, DT.493912, DT.91342930, DT.94132974, DT.97415609
PDB2D2Q, 2EMS, 2EMT, 2YVC, 2ZPY, 1GC6, 1GC7, 1J19, 2D10, 2D11
Consensus CDS ProjectCCDS40634.1, CCDS52793.1
International Mouse Knockout Project StatusRdx
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032050 Ensembl Gene Model | MGI Sequence Detail 41588 C57BL/6J ±  kb
transcript ENSMUST00000163153 Ensembl | MGI Sequence Detail 4156 Not Applicable 
polypeptide ENSMUSP00000128249 Ensembl | MGI Sequence Detail 583 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(6) UniProt(8)
Polymorphisms
SNPs within 2kb(197 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019749 Band 4.1 domain
InterPro IPR019750 Band 4.1 family
InterPro IPR011174 Ezrin/radixin/moesin
InterPro IPR011259 Ezrin/radixin/moesin, C-terminal
InterPro IPR000798 Ezrin/radixin/moesin like
InterPro IPR014352 FERM/acyl-CoA-binding protein, 3-helical bundle
InterPro IPR019748 FERM central domain
InterPro IPR019747 FERM conserved site
InterPro IPR018980 FERM, C-terminal PH-like domain
InterPro IPR000299 FERM domain
InterPro IPR018979 FERM, N-terminal
InterPro IPR008954 Moesin
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000003009 radixin
References
(Earliest) J:35128 Funayama N, et al., Radixin is a novel member of the band 4.1 family. J Cell Biol. 1991 Nov;115(4):1039-48
(Latest) J:193640 Lo JC, et al., RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. PLoS Genet. 2012;8(10):e1002969
All references(62)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-13819, MGI:2142943

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory