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Rcvrn Gene Detail
Summary
  • Symbol
    Rcvrn
  • Name
    recoverin
  • Synonyms
    cancer associated retinopathy protein, guanylate cyclase activator, S-modulin
  • Feature Type
    protein coding gene
  • IDs
    MGI:97883
    NCBI Gene: 19674
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:67695326-67703333 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 41.13 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    83 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97883
protein coding gene Chr11:67695326-67703355 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018493
protein coding gene Chr11:68013576-68021606 (+)
A/J MGP_AJ_G0018462
protein coding gene Chr11:65466200-65474278 (+)
AKR/J MGP_AKRJ_G0018431
protein coding gene Chr11:67420331-67428347 (+)
BALB/cJ MGP_BALBcJ_G0018433
protein coding gene Chr11:65746650-65754627 (+)
C3H/HeJ MGP_C3HHeJ_G0018246
protein coding gene Chr11:67436269-67444296 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018885
protein coding gene Chr11:70081362-70089367 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016529
protein coding gene Chr11:62416254-62424350 (+)
CAST/EiJ MGP_CASTEiJ_G0017802
protein coding gene Chr11:67663080-67671138 (+)
CBA/J MGP_CBAJ_G0018220
protein coding gene Chr11:73178209-73186174 (+)
DBA/2J MGP_DBA2J_G0018329
protein coding gene Chr11:65069347-65077328 (+)
FVB/NJ MGP_FVBNJ_G0018319
protein coding gene Chr11:64672321-64680373 (+)
LP/J MGP_LPJ_G0018400
protein coding gene Chr11:68581645-68589675 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018342
protein coding gene Chr11:73937055-73945071 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018926
protein coding gene Chr11:67673527-67681568 (+)
PWK/PhJ MGP_PWKPhJ_G0017577
protein coding gene Chr11:65682312-65690594 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017365
protein coding gene Chr11:67496916-67506445 (+)
WSB/EiJ MGP_WSBEiJ_G0017855
protein coding gene Chr11:67276347-67284363 (+)



Homology
more
  • Human Ortholog
    RCVRN, recoverin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RCVRN, recoverin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RCV1
  • Links
    NCBI Gene ID: 5957
    neXtProt AC: NX_P35243
    UniProt: P35243

  • Chr Location
    17p13.1; chr17:9897710-9905367 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2177
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RCVRN
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit faster flash response recovery in dark-adapted rods, decreased sensitivity of rods to steps of light and altered kinetics of sodium/calcium-potassium exchange in rods.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020907 Ensembl Gene Model | MGI Sequence Detail 8008 C57BL/6J ±  kb
    transcript ENSMUST00000021290 Ensembl | MGI Sequence Detail 1040 Not Applicable  
    polypeptide ENSMUSP00000021290 Ensembl | MGI Sequence Detail 202 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 7
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13806
    References
    more
    • Summaries
      All 93
      Developmental Gene Expression 60
      Gene Ontology 3
      Phenotypes 9
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:301112 Maddala R, et al., Absence of S100A4 in the mouse lens induces an aberrant retina-specific differentiation program and cataract. Sci Rep. 2021 Jan 26;11(1):2203

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    04/06/2021
    MGI 6.16
    The Jackson Laboratory