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Rcvrn
Gene Detail
Symbol

Name
ID
Rcvrn
recoverin
MGI:97883
Synonyms
cancer associated retinopathy protein, guanylate cyclase activator, S-modulin
Feature Type
protein coding gene
Genetic Map
Chromosome 11
41.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:67695326-67703333 bp, + strand
From VEGA annotation of GRCm38

  8008 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2177  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Gene Tree: Rcvrn

Human
homologs
Human Homolog RCVRN, recoverin
NCBI Gene ID 5957
neXtProt AC  NX_P35243
Human Synonyms  RCV1
Human Chr (Location)  17p13.1; chr17:9897710-9905367 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
 
Homozygous mutant mice exhibit faster flash response recovery in dark-adapted rods, decreased sensitivity of rods to steps of light and altered kinetics of sodium/calcium-potassium exchange in rods.
 
Interactions
Rcvrn interacts with 48 markers (Mir27b, Mir28b, Mir28c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process phototransduction, regulation of calcium ion transport, ...
Component dendrite
Function calcium ion binding, metal ion binding
External Resources: FuncBase
Expression
Literature Summary: (34 records)
Data Summary: Results (4)    Tissues (2)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 2
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(6)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000005933 (Evidence)
Ensembl Gene ModelENSMUSG00000020907 (Evidence)
Entrez Gene19674 (Evidence)
Consensus CDS ProjectCCDS24859.1
International Mouse Knockout Project StatusRcvrn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005933 VEGA Gene Model | MGI Sequence Detail 8008 C57BL/6J ±  kb
transcript OTTMUST00000013215 VEGA | MGI Sequence Detail 1040 Not Applicable 
polypeptide OTTMUSP00000006130 VEGA | MGI Sequence Detail 202 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(2) : SNPs within 2kb(84 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
Protein Ontology PR:000013845 recoverin
References
(Earliest) J:970 McGinnis JF, et al., Cloning and sequencing of the 23 kDa mouse photoreceptor cell-specific protein. FEBS Lett. 1992 May 11;302(2):172-6
(Latest) J:206963 Orieux G, et al., Involvement of Bcl-2-associated transcription factor 1 in the differentiation of early-born retinal cells. J Neurosci. 2014 Jan 22;34(4):1530-41
All references(61)
Other
accession IDs
MGD-MRK-13806

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory