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Rara
Gene Detail
Symbol

Name
ID
Rara
retinoic acid receptor, alpha
MGI:97856
Synonyms
RARalpha1, RAR alpha 1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
62.76 cM, cytoband D-E1
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr11:98927818-98974942 bp, + strand
From VEGA annotation of GRCm38

  47125 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20262  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: retinoic acid receptor
Gene Tree: Rara

Human
homologs
Human Homolog RARA, retinoic acid receptor, alpha
NCBI Gene ID 5914
neXtProt AC  NX_P10276
Human Synonyms  NR1B1, RAR
Human Chr (Location)  17q21; chr17:40309171-40357643 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human RARA
Mutations,
alleles, and
phenotypes
All mutations/alleles(109) : Gene trapped(100) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations show high neonatal mortality due to maternal cannibalization, failure to thrive, and excess mortality during the postnatal period. Male survivors exhibit testicular degeneration.
 
Phenotype Images(1)
Interactions
Rara interacts with 192 markers (Mir7-1, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (125 annotations)
Process apoptotic cell clearance, bone development, ...
Component cytoplasm, dendrite, ...
Function chromatin DNA binding, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (78 records)
Data Summary: Results (614)    Tissues (360)    Images (72)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 405
Northern blot 45
Western blot 16
RT-PCR 99
RNase protection 48
cDNA source data(57)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(96) Genomic(5) cDNA(66) Primer pair(18) Other(7)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000006440 (Evidence)
Ensembl Gene ModelENSMUSG00000037992 (Evidence)
Entrez Gene19401 (Evidence)
UniGene439744
DFCITC1579190, TC1589016, TC1615122, TC1626953, TC1726236
DoTSDT.101366332, DT.110512960, DT.110513020, DT.110513032, DT.110513042, DT.481371, DT.91382373, DT.94309873, DT.99841871, DT.99850751
NIA Mouse Gene IndexU013319
Consensus CDS ProjectCCDS36304.1, CCDS48905.1
International Mouse Knockout Project StatusRara
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006440 VEGA Gene Model | MGI Sequence Detail 47125 C57BL/6J ±  kb
transcript OTTMUST00000014708 VEGA | MGI Sequence Detail 2380 Not Applicable 
polypeptide OTTMUSP00000006836 VEGA | MGI Sequence Detail 462 Not Applicable 

For the selected sequences
All sequences(90) RefSeq(24) UniProt(5)
Polymorphisms
RFLP(4) : SNPs within 2kb(122 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR003078 Retinoic acid receptor
InterPro IPR001723 Steroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000013736 retinoic acid receptor alpha
References
(Earliest) J:9853 Harada M, et al., Strain difference and mode of inheritance of the susceptibility to passive cutaneous anaphylaxis mediated by allogeneic IgE antibody in the mouse. Immunol Invest. 1989 Jun;18(5):723-35
(Latest) J:210244 Guo Y, et al., Dissecting the role of retinoic acid receptor isoforms in the CD8 response to infection. J Immunol. 2014 Apr 1;192(7):3336-44
All references(271)
Other
accession IDs
MGD-MRK-13766

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory