Rara
Gene Detail

Symbol Name ID

Rara retinoic acid receptor, alpha MGI:97856

Synonyms

RARalpha1, RAR alpha 1

Feature Type

protein coding gene

Genetic Map

Chromosome 11

62.76 cM, cytoband D-E1
Detailed Genetic Map ± 1 cM


Mapping data(15)

Sequence Map

Chr11:98927818-98974942 bp, + strand From VEGA annotation of GRCm38   47125 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20262  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: retinoic acid receptor
Gene Tree: Rara

Human homologs

Human Homolog		RARA, retinoic acid receptor, alpha
NCBI Gene ID		5914
neXtProt AC		NX_P10276
Human Synonyms		NR1B1, RAR
Human Chr (Location)		17q21; chr17:38465423-38513895 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human RARA

Alleles and phenotypes

All alleles(109) : Targeted(9) Gene trapped(100)
 

Homozygotes for targeted null mutations show high neonatal mortality due to maternal cannibalization, failure to thrive, and excess mortality during the postnatal period. Male survivors exhibit testicular degeneration.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (111 annotations)

Process	apoptotic cell clearance, cellular response to estrogen stimulus, ...
Component	cytoplasm, dendrite, ...
Function	chromatin DNA binding, DNA binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (77 records)
Data Summary: Results (616)    Tissues (353)    Images (68)
Theiler Stages: 2, 3, 4, 5, 9, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	1
RNA in situ	402
Northern blot	45
Western blot	15
RT-PCR	105
RNase protection	48

cDNA source data(57)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(94) Genomic(5) cDNA(65) Primer pair(17) Other(7)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000006440 (Evidence)
Ensembl Gene Model	ENSMUSG00000037992 (Evidence)
Entrez Gene	19401 (Evidence)
UniGene	439744
DFCI	TC1579190, TC1589016, TC1615122, TC1626953, TC1726236
DoTS	DT.101366332, DT.110512960, DT.110513020, DT.110513032, DT.110513042, DT.481371, DT.91382373, DT.94309873, DT.99841871, DT.99850751
NIA Mouse Gene Index	U013319
Consensus CDS Project	CCDS36304.1, CCDS48905.1
International Mouse Knockout Project Status	Rara

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006440	VEGA Gene Model | MGI Sequence Detail	47125	C57BL/6J
transcript	OTTMUST00000014708	VEGA | MGI Sequence Detail	2380	Not Applicable
polypeptide	OTTMUSP00000006836	VEGA | MGI Sequence Detail	462	Not Applicable

All sequences(74) RefSeq(8) UniProt(5)

Polymorphisms

RFLP(4) : SNPs(103 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008946	Nuclear hormone receptor, ligand-binding
InterPro	IPR000536	Nuclear hormone receptor, ligand-binding, core
InterPro	IPR003078	Retinoic acid receptor
InterPro	IPR001723	Steroid hormone receptor
InterPro	IPR013088	Zinc finger, NHR/GATA-type
InterPro	IPR001628	Zinc finger, nuclear hormone receptor-type
Protein Ontology	PR:000013736	retinoic acid receptor alpha

References

(Earliest) J:9853 Harada M, et al., Strain difference and mode of inheritance of the susceptibility to passive cutaneous anaphylaxis mediated by allogeneic IgE antibody in the mouse. Immunol Invest. 1989 Jun;18(5):723-35
(Latest) J:193750 Chee LC, et al., The granulocyte-colony stimulating factor receptor (G-CSFR) interacts with retinoic acid receptors (RARs) in the regulation of myeloid differentiation. J Leukoc Biol. 2013 Feb;93(2):235-43
All references(264)

Other accession IDs

MGD-MRK-13766