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Rac2
Gene Detail
Symbol

Name
ID
Rac2
RAS-related C3 botulinum substrate 2
MGI:97846
Feature Type
protein coding gene
Genetic Map
Chromosome 15
37.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:78559169-78572783 bp, - strand
From NCBI annotation of GRCm38

  13615 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55699  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RAC2
Protein SuperFamily: small GTPase, Rho type
Gene Tree: Rac2

Human
homologs
RAC2, ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5880
neXtProt AC: NX_P15153

Human Synonyms: EN-7, Gx, HSPC022, p21-Rac2

Human Chr (Location): 22q13.1; chr22:37225261-37244299 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human RAC2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Gene trapped(2) Radiation induced(1) Targeted(1)
Genomic Mutations involving Rac2 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit peripheral blood lymphocytosis, reductions in peritoneal B-1a lymphocytes, marginal zone lymphocytes, and IgM-secreting plasma cells, decreased levels of serum IgM and IgA, and abnormal T cell migration.
 
Phenotype Images(2)
Interactions
Rac2 interacts with 233 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process actin cytoskeleton organization, actin filament organization, ...
Component actin filament, cytoplasm, ...
Function GTPase activity, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (24)    Tissues (15)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
cDNA source data(75)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA RAC2 ; Xenbase rac2 ; ZFIN rac2    NEW 
Molecular
reagents
All nucleic(76) cDNA(76)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000033220 (Evidence)
Entrez Gene 19354 (Evidence)
UniGene 1972
DFCI TC1576323, TC1654563
DoTS DT.494325
NIA Mouse Gene Index U036387
Consensus CDS Project CCDS27619.1
International Mouse Phenotyping Consortium Status Rac2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 19354 NCBI Gene Model | MGI Sequence Detail 13615 C57BL/6J ±  kb
transcript NM_009008 RefSeq | MGI Sequence Detail 3036 C57BL/6 
polypeptide Q05144 UniProt | EBI | MGI Sequence Detail 192 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(106 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR003578 Small GTPase superfamily, Rho type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000013661 ras-related C3 botulinum toxin substrate 2
Graphical View of Protein Domain Structure
References
(Earliest) J:10526 Shirsat NV, et al., A member of the ras gene superfamily is expressed specifically in T, B and myeloid hemopoietic cells. Oncogene. 1990 May;5(5):769-72
(Latest) J:221504 Pan D, et al., P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation. Blood. 2015 Feb 12;125(7):1146-58
All references(125)
Other
accession IDs
MGD-MRK-13749, MGI:2145980, MGI:2146018

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory