Rac2
Gene Detail

Symbol Name ID

Rac2 RAS-related C3 botulinum substrate 2 MGI:97846

Feature Type

protein coding gene

Genetic Map

Chromosome 15

37.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr15:78559169-78572783 bp, - strand From NCBI annotation of GRCm38   13615 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55699  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: small GTPase, Rho type
Gene Tree: Rac2

Human homologs

Human Homolog		RAC2, ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
NCBI Gene ID		5880
neXtProt AC		NX_P15153
Human Synonyms		EN-7, Gx, HSPC022
Human Chr (Location)		22q13.1; chr22:37621310-37640305 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human RAC2

Alleles and phenotypes

All alleles(3) : Targeted(1) Gene trapped(2)
 

Homozygotes for a targeted null mutation exhibit peripheral blood lymphocytosis, reductions in peritoneal B-1a lymphocytes, marginal zone lymphocytes, and IgM-secreting plasma cells, decreased levels of serum IgM and IgA, and abnormal T cell migration.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	actin cytoskeleton organization, bone resorption, ...
Component	cytoplasm, intracellular, ...
Function	GTPase activity, GTP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (24)    Tissues (15)    Images (2)
Theiler Stages: 23

Assay Type	Results
RNA in situ	24

cDNA source data(75)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(76) cDNA(76)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000033220 (Evidence)
Entrez Gene	19354 (Evidence)
UniGene	1972
DFCI	TC1576323, TC1654563
DoTS	DT.494325
NIA Mouse Gene Index	U036387
Consensus CDS Project	CCDS27619.1
International Mouse Knockout Project Status	Rac2

Sequences

Length	Strain/Species
genomic	19354	NCBI Gene Model | MGI Sequence Detail	13615	C57BL/6J
transcript	NM_009008	RefSeq | MGI Sequence Detail	3036	C57BL/6
polypeptide	Q05144	UniProt | EBI | MGI Sequence Detail	192	Not Applicable

All sequences(26) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(92 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001806	Small GTPase superfamily
InterPro	IPR003578	Small GTPase superfamily, Rho type
InterPro	IPR005225	Small GTP-binding protein domain
Protein Ontology	PR:000013661	ras-related C3 botulinum toxin substrate 2

Graphical View of Protein Domain Structure

References

(Earliest) J:10526 Shirsat NV, et al., A member of the ras gene superfamily is expressed specifically in T, B and myeloid hemopoietic cells. Oncogene. 1990 May;5(5):769-72
(Latest) J:189090 Chang KH, et al., Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival. Blood. 2012 Jul 26;120(4):800-11
All references(116)

Other accession IDs

MGD-MRK-13749, MGI:2145980, MGI:2146018