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Rac2 Gene Detail
Summary
  • Symbol
    Rac2
  • Name
    RAS-related C3 botulinum substrate 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:97846
    NCBI Gene: 19354
  • Gene Overview
    MyGene.info: RAC2
Location & Maps
more
  • Sequence Map
    Chr15:78559169-78572783 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13615 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 37.57 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    RAC2, ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RAC2, ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EN-7, Gx, HSPC022, p21-Rac2
  • Links
    NCBI Gene ID: 5880
    neXtProt AC: NX_P15153

  • Chr Location
    22q13.1; chr22:37225261-37244299 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human RAC2 associations

Human Disease Mouse Models
       Neutrophil Immunodeficiency Syndrome   OMIM: 608203
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 4 alleles in 6 genetic backgrounds
    9 phenotypes from multigenic genotypes
    92 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (ENU)
    3
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Radiation induced
    2
  • Targeted
    1
  • Genomic Mutations
    3 involving Rac2
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit peripheral blood lymphocytosis, reductions in peritoneal B-1a lymphocytes, marginal zone lymphocytes, and IgM-secreting plasma cells, decreased levels of serum IgM and IgA, and abnormal T cell migration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19354 NCBI Gene Model | MGI Sequence Detail 13615 C57BL/6J ±  kb
transcript NM_009008 RefSeq | MGI Sequence Detail 3036 C57BL/6  
polypeptide Q05144 UniProt | EBI | MGI Sequence Detail 192 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    106 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 76
    cDNA 76

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-13749, MGI:2145980, MGI:2146018
References
more
  • Summaries
    All 124
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 11
    Phenotypes 92
  • Earliest
    J:10526 Shirsat NV, et al., A member of the ras gene superfamily is expressed specifically in T, B and myeloid hemopoietic cells. Oncogene. 1990 May;5(5):769-72
  • Latest
    J:221504 Pan D, et al., P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation. Blood. 2015 Feb 12;125(7):1146-58

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory