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Rac2
Gene Detail
Symbol

Name
ID
Rac2
RAS-related C3 botulinum substrate 2
MGI:97846
Feature Type
protein coding gene
Genetic Map
Chromosome 15
37.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:78559169-78572783 bp, - strand
From NCBI annotation of GRCm38

  13615 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55699  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: small GTPase, Rho type
Gene Tree: Rac2

Human
homologs
Human Homolog RAC2, ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
NCBI Gene ID 5880
neXtProt AC  NX_P15153
Human Synonyms  EN-7, Gx, HSPC022, p21-Rac2
Human Chr (Location)  22q13.1; chr22:37225261-37244299 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human RAC2
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Radiation induced(1) Targeted(1)
Genomic Mutations involving Rac2 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit peripheral blood lymphocytosis, reductions in peritoneal B-1a lymphocytes, marginal zone lymphocytes, and IgM-secreting plasma cells, decreased levels of serum IgM and IgA, and abnormal T cell migration.
 
Interactions
Rac2 interacts with 233 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process actin cytoskeleton organization, actin filament organization, ...
Component actin filament, cytoplasm, ...
Function GTPase activity, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (24)    Tissues (15)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
cDNA source data(75)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(76) cDNA(76)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000033220 (Evidence)
Entrez Gene19354 (Evidence)
UniGene1972
DFCITC1576323, TC1654563
DoTSDT.494325
NIA Mouse Gene IndexU036387
Consensus CDS ProjectCCDS27619.1
International Mouse Knockout Project StatusRac2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 19354 NCBI Gene Model | MGI Sequence Detail 13615 C57BL/6J ±  kb
transcript NM_009008 RefSeq | MGI Sequence Detail 3036 C57BL/6 
polypeptide Q05144 UniProt | EBI | MGI Sequence Detail 192 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(106 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR003578 Small GTPase superfamily, Rho type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000013661 ras-related C3 botulinum toxin substrate 2
Graphical View of Protein Domain Structure
References
(Earliest) J:10526 Shirsat NV, et al., A member of the ras gene superfamily is expressed specifically in T, B and myeloid hemopoietic cells. Oncogene. 1990 May;5(5):769-72
(Latest) J:205191 Sima C, et al., Rac-null leukocytes are associated with increased inflammation-mediated alveolar bone loss. Am J Pathol. 2014 Feb;184(2):472-82
All references(121)
Other
accession IDs
MGD-MRK-13749, MGI:2145980, MGI:2146018

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory