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Eprs Gene Detail
Summary
  • Symbol
    Eprs
  • Name
    glutamyl-prolyl-tRNA synthetase
  • Synonyms
    2410081F06Rik, 3010002K18Rik, Qprs
  • Feature Type
    protein coding gene
  • IDs
    MGI:97838
    NCBI Gene: 107508
  • Gene Overview
    MyGene.info: EPRS1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:185363044-185428360 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 89.50 cM, cytoband H4-H6
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    888 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97838
protein coding gene Chr1:185361554-185428360 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016916
protein coding gene Chr1:192095319-192165772 (+)
A/J MGP_AJ_G0016895
protein coding gene Chr1:184240793-184305776 (+)
AKR/J MGP_AKRJ_G0016860
protein coding gene Chr1:189659936-189735917 (+)
BALB/cJ MGP_BALBcJ_G0016853
protein coding gene Chr1:184882526-184947464 (+)
C3H/HeJ MGP_C3HHeJ_G0016677
protein coding gene Chr1:190539233-190606541 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017316
protein coding gene Chr1:198224248-198299488 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015023
protein coding gene Chr1:175224313-175292923 (+)
CAST/EiJ MGP_CASTEiJ_G0016260
protein coding gene Chr1:189964860-190036547 (+)
CBA/J MGP_CBAJ_G0016651
protein coding gene Chr1:205619693-205691929 (+)
DBA/2J MGP_DBA2J_G0016757
protein coding gene Chr1:182998384-183064178 (+)
FVB/NJ MGP_FVBNJ_G0016753
protein coding gene Chr1:181100754-181165281 (+)
LP/J MGP_LPJ_G0016832
protein coding gene Chr1:193246362-193314828 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016785
protein coding gene Chr1:212496148-212566173 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017353
protein coding gene Chr1:189540309-189610407 (+)
PWK/PhJ MGP_PWKPhJ_G0016047
protein coding gene Chr1:182208804-182276153 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015823
protein coding gene Chr1:188496098-188564847 (+)
WSB/EiJ MGP_WSBEiJ_G0016322
protein coding gene Chr1:189707257-189775165 (+)



Homology
more
  • Human Ortholog
    EPRS1, glutamyl-prolyl-tRNA synthetase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EPRS1, glutamyl-prolyl-tRNA synthetase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EARS, EPRS, GLUPRORS, HLD15, PARS, PIG32, QARS, QPRS
  • Links
    NCBI Gene ID: 2058
    neXtProt AC: NX_P07814
    UniProt: P07814

  • Chr Location
    1q41; chr1:219968600-220046658 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 3 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a phospho-mimetic allele exhibit normal body weight, life span and glucose metabolism. Mice homozygous for a phospho-deficient allele exhibit decrease body weight, enhanced lipolysis, altered glucose metabolism and increased energy expenditure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026615 Ensembl Gene Model | MGI Sequence Detail 65317 C57BL/6J ±  kb
    transcript ENSMUST00000046514 Ensembl | MGI Sequence Detail 4906 Not Applicable  
    polypeptide ENSMUSP00000045841 Ensembl | MGI Sequence Detail 1512 Not Applicable  
    For the selected sequence
    Protein
    Information
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    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000007144 bifunctional glutamate/proline--tRNA ligase
    • EC
    • InterPro Domains
      IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site
      IPR006195 Aminoacyl-tRNA synthetase, class II
      IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)
      IPR004154 Anticodon-binding
      IPR036621 Anticodon-binding domain superfamily
      IPR000924 Glutamyl/glutaminyl-tRNA synthetase
      IPR020059 Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain
      IPR020058 Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain
      IPR004526 Glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolic
      IPR004046 Glutathione S-transferase, C-terminal
      IPR036282 Glutathione S-transferase, C-terminal domain superfamily
      IPR004499 Proline-tRNA ligase, class IIa, archaeal-type
      IPR016061 Proline-tRNA ligase, class II, C-terminal
      IPR033721 Prolyl-tRNA synthetase, catalytic domain
      IPR017449 Prolyl-tRNA synthetase, class II
      IPR011035 Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain superfamily
      IPR020056 Ribosomal protein L25/Gln-tRNA synthetase, N-terminal
      IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
      IPR009068 S15/NS1, RNA-binding
      IPR000738 WHEP-TRS domain
    Molecular
    Reagents
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    • All nucleic 35
      cDNA 33
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-13739, MGI:1919640, MGI:1924024, MGI:2138682
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 13
    • Earliest
      J:16735 Kaiser E, et al., The human EPRS locus (formerly the QARS locus): a gene encoding a class I and a class II aminoacyl-tRNA synthetase. Genomics. 1994 Jan 15;19(2):280-90
    • Latest
      J:244749 Arif A, et al., EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice. Nature. 2017 Feb 16;542(7641):357-361

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory