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Eprs
Gene Detail
 Symbol
Name
ID
Eprs
glutamyl-prolyl-tRNA synthetase
MGI:97838
Synonyms 2410081F06Rik, 3010002K18Rik, Qprs
Feature Type protein coding gene
Genetic Map
Chromosome 1
89.50 cM, cytoband H4-H6
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:185363095-185428355 bp, + strand
From NCBI annotation of GRCm38

  65261 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5870  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: human multifunctional amino acid-tRNA ligase
Gene Tree: Eprs

Human
homologs
Human Homolog EPRS, glutamyl-prolyl-tRNA synthetase
NCBI Gene ID 2058
neXtProt AC  NX_P07814
Human Synonyms  EARS, GLUPRORS, PARS, QARS, QPRS
Human Chr (Location)  1q41; chr1:219968600-220046658 (-)  GRCh38
Alleles
and
phenotypes
All alleles(31) : Gene trapped(28) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process cellular response to interferon-gamma, glutamyl-tRNA aminoacylation, ...
Component cytoplasm, GAIT complex, ...
Function aminoacyl-tRNA ligase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (131)    Tissues (98)    Images (24)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 131
cDNA source data(26)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(33) cDNA(31) Primer pair(2)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000026615 (Evidence)
Entrez Gene107508 (Evidence)
DFCITC1598969, TC1602270, TC1653556, TC1710705
DoTSDT.101268330, DT.101389843, DT.102550578, DT.537012, DT.94210661, DT.94211716, DT.97415409
NIA Mouse Gene IndexU001246
EC6.1.1.15, 6.1.1.17
Consensus CDS ProjectCCDS35818.1
International Mouse Knockout Project StatusEprs
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 107508 NCBI Gene Model | MGI Sequence Detail 65261 C57BL/6J ±  kb
transcript NM_029735 RefSeq | MGI Sequence Detail 4850 C57BL/6 
polypeptide Q8CGC7 UniProt | EBI | MGI Sequence Detail 1512 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(6) UniProt(7)
Polymorphisms SNPs within 2kb(895 from dbSNP Build 137)    SNPs within 2kb including multiple locations(901)
Protein-related
information
ResourceIDDescription
InterPro IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site
InterPro IPR006195 Aminoacyl-tRNA synthetase, class II
InterPro IPR002314 Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain
InterPro IPR004154 Anticodon-binding
InterPro IPR000924 Glutamyl/glutaminyl-tRNA synthetase, class Ib
InterPro IPR020061 Glutamyl/glutaminyl-tRNA synthetase, class Ib, alpha-bundle domain
InterPro IPR020059 Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain
InterPro IPR020058 Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain
InterPro IPR004526 Glutamyl-tRNA synthetase, class Ib, archaeal/eukaryotic cytosolic
InterPro IPR004046 Glutathione S-transferase, C-terminal
InterPro IPR010987 Glutathione S-transferase, C-terminal-like
InterPro IPR004499 Proline-tRNA ligase, class IIa, archaeal-type
InterPro IPR016061 Proline-tRNA ligase, class II, C-terminal
InterPro IPR017449 Prolyl-tRNA synthetase, class II
InterPro IPR011035 Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain
InterPro IPR020056 Ribosomal protein L25/Gln-tRNA synthetase, beta-barrel domain
InterPro IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
InterPro IPR009068 S15/NS1, RNA-binding
InterPro IPR000738 WHEP-TRS
Protein Ontology PR:000007144 bifunctional aminoacyl-tRNA synthetase
Graphical View of Protein Domain Structure
References (Earliest) J:16735 Kaiser E, et al., The human EPRS locus (formerly the QARS locus): a gene encoding a class I and a class II aminoacyl-tRNA synthetase. Genomics. 1994 Jan 15;19(2):280-90
(Latest) J:192858 Arif A, et al., Heterotrimeric GAIT complex drives transcript-selective translation inhibition in murine macrophages. Mol Cell Biol. 2012 Dec;32(24):5046-55
All references(43)
Other
accession IDs
MGD-MRK-13739, MGI:1919640, MGI:1924024, MGI:2138682

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory