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Ptger3 Gene Detail
Summary
  • Symbol
    Ptger3
  • Name
    prostaglandin E receptor 3 (subtype EP3)
  • Synonyms
    EP3, Pgerep3, Ptgerep3
  • Feature Type
    protein coding gene
  • IDs
    MGI:97795
    NCBI Gene: 19218
  • Gene Overview
    MyGene.info: PTGER3
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:157566816-157644758 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 81.32 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    339 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97795
protein coding gene Chr3:157566816-157645888 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028012
protein coding gene Chr3:161705678-161787277 (+)
A/J MGP_AJ_G0027970
protein coding gene Chr3:155813239-155896700 (+)
AKR/J MGP_AKRJ_G0027936
protein coding gene Chr3:159949175-160031259 (+)
BALB/cJ MGP_BALBcJ_G0027982
protein coding gene Chr3:155620851-155704002 (+)
C3H/HeJ MGP_C3HHeJ_G0027712
protein coding gene Chr3:160349506-160436278 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028425
protein coding gene Chr3:166989030-167072748 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025764
protein coding gene Chr3:150436135-150518381 (+)
CAST/EiJ MGP_CASTEiJ_G0027165
protein coding gene Chr3:160481681-160569065 (+)
CBA/J MGP_CBAJ_G0027687
protein coding gene Chr3:172929328-173020940 (+)
DBA/2J MGP_DBA2J_G0027827
protein coding gene Chr3:154859965-154940327 (+)
FVB/NJ MGP_FVBNJ_G0027794
protein coding gene Chr3:152210298-152291981 (+)
LP/J MGP_LPJ_G0027938
protein coding gene Chr3:163036690-163122229 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027827
protein coding gene Chr3:181537640-181625371 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028484
protein coding gene Chr3:159637076-159722822 (+)
PWK/PhJ MGP_PWKPhJ_G0026888
protein coding gene Chr3:154796288-154876639 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026716
protein coding gene Chr3:157852534-157940161 (+)
WSB/EiJ MGP_WSBEiJ_G0027245
protein coding gene Chr3:160604830-160687246 (+)



Homology
more
  • Human Ortholog
    PTGER3, prostaglandin E receptor 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PTGER3, prostaglandin E receptor 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EP3, EP3e, EP3-I, EP3-II, EP3-III, EP3-IV, EP3-VI, PGE2-R
  • Links
    NCBI Gene ID: 5733
    neXtProt AC: NX_P43115
    UniProt: P43115

  • Chr Location
    1p31.1; chr1:70852353-71047814 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 3 alleles in 8 genetic backgrounds
    80 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit increased basal renal blood flow, decreased resting renal vascular resistance, impaired duodenal bicarbonate secretion and mucosal integrity, and impaired responses to endotoxin.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19218 NCBI Gene Model | MGI Sequence Detail 77943 C57BL/6J ±  kb
    transcript NM_001359745 RefSeq | MGI Sequence Detail 2202 C57BL/6  
    polypeptide P30557 UniProt | EBI | MGI Sequence Detail 365 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 1
      cDNA 14
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13257, MGD-MRK-13662
    References
    more
    • Summaries
      All 136
      Developmental Gene Expression 6
      Gene Ontology 15
      Phenotypes 80
    • Earliest
      J:229737 Idell S, et al., Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndrome. J Clin Invest. 1989 Aug;84(2):695-705
    • Latest
      J:263602 Chen D, et al., E-Prostanoid 3 Receptor Mediates Sprouting Angiogenesis Through Suppression of the Protein Kinase A/beta-Catenin/Notch Pathway. Arterioscler Thromb Vasc Biol. 2017 May;37(5):856-866

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory