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Ptger3
Gene Detail
 Symbol
Name
ID
Ptger3
prostaglandin E receptor 3 (subtype EP3)
MGI:97795
Synonyms EP3, Pgerep3, Ptgerep3
Feature Type protein coding gene
Genetic Map
Chromosome 3
81.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:157566892-157644758 bp, + strand
From VEGA annotation of GRCm38

  77867 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:105703  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: G protein-coupled prostanoid receptor
Gene Tree: Ptger3

Human
homologs
Human Homolog PTGER3, prostaglandin E receptor 3 (subtype EP3)
NCBI Gene ID 5733
neXtProt AC  NX_P43115
Human Synonyms  EP3, EP3e, EP3-I, EP3-II, EP3-III, EP3-IV, PGE2-R
Human Chr (Location)  1p31.2; chr1:70852353-71047808 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
 
Homozygotes for targeted null mutations exhibit increased basal renal blood flow, decreased resting renal vascular resistance, impaired duodenal bicarbonate secretion and mucosal integrity, and impaired responses to endotoxin.
 
Interactions
Ptger3 interacts with 145 markers (Mir1a-1, Mir1a-2, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process adenylate cyclase-modulating G-protein coupled receptor signaling pathway, bicarbonate transport, ...
Component cytosol, integral component of membrane, ...
Function G-protein coupled receptor activity, prostaglandin E receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (138)    Tissues (45)    Images (3)
Theiler Stages: 23, 28
Assay TypeResults
RT-PCR 138
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(13) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000037109 (Evidence)
Ensembl Gene ModelENSMUSG00000040016 (Evidence)
Entrez Gene19218 (Evidence)
UniGene30424
DFCITC1586711, TC1593242
DoTSDT.101360044, DT.94124448, DT.94131249
NIA Mouse Gene IndexU004023
Consensus CDS ProjectCCDS17932.1
International Mouse Knockout Project StatusPtger3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037109 VEGA Gene Model | MGI Sequence Detail 77867 C57BL/6J ±  kb
transcript OTTMUST00000095548 VEGA | MGI Sequence Detail 2097 Not Applicable 
polypeptide OTTMUSP00000053314 VEGA | MGI Sequence Detail 366 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(8) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(339 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR001244 Prostaglandin DP receptor
InterPro IPR000265 Prostanoid EP3 receptor
InterPro IPR000154 Prostanoid EP3 receptor type 3
InterPro IPR008365 Prostanoid receptor
Protein Ontology PR:000001659 prostaglandin E2 receptor EP3 subtype
References (Earliest) J:150 Sugimoto Y, et al., Cloning and expression of a cDNA for mouse prostaglandin E receptor EP3 subtype. J Biol Chem. 1992 Apr 5;267(10):6463-6
(Latest) J:207320 Morimoto K, et al., Prostaglandin E2-EP3 signaling induces inflammatory swelling by mast cell activation. J Immunol. 2014 Feb 1;192(3):1130-7
All references(116)
Other
accession IDs
MGD-MRK-13257, MGD-MRK-13662

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory