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Ptger3
Gene Detail
Symbol

Name
ID
Ptger3
prostaglandin E receptor 3 (subtype EP3)
MGI:97795
Synonyms
EP3, Pgerep3, Ptgerep3
Feature Type
protein coding gene
Genetic Map
Chromosome 3
81.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:157566892-157645888 bp, + strand
From VEGA annotation of GRCm38

  78997 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:105703  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PTGER3
Protein SuperFamily: G protein-coupled prostanoid receptor
Gene Tree: Ptger3

Human
homologs
PTGER3, prostaglandin E receptor 3 (subtype EP3)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5733
neXtProt AC: NX_P43115

Human Synonyms: EP3, EP3e, EP3-I, EP3-II, EP3-III, EP3-IV, EP3-VI, PGE2-R

Human Chr (Location): 1p31.2; chr1:70852353-71047814 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from CvDC )
 
Homozygotes for targeted null mutations exhibit increased basal renal blood flow, decreased resting renal vascular resistance, impaired duodenal bicarbonate secretion and mucosal integrity, and impaired responses to endotoxin.
 
Interactions
Ptger3 interacts with 145 markers (Mir1a-1, Mir1a-2, Mir10a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (138)    Tissues (45)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 138
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ptger3 ; ZFIN ptger3    NEW 
Molecular
reagents
All nucleic(16) cDNA(13) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000037109 (Evidence)
Ensembl Gene Model ENSMUSG00000040016 (Evidence)
Entrez Gene 19218 (Evidence)
UniGene 30424
DFCI TC1586711, TC1593242
DoTS DT.101360044, DT.94124448, DT.94131249
NIA Mouse Gene Index U004023
Consensus CDS Project CCDS17932.1
International Mouse Phenotyping Consortium Status Ptger3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037109 VEGA Gene Model | MGI Sequence Detail 78997 C57BL/6J ±  kb
transcript OTTMUST00000095548 VEGA | MGI Sequence Detail 2097 Not Applicable 
polypeptide OTTMUSP00000053314 VEGA | MGI Sequence Detail 366 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(8) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(340 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR001244 Prostaglandin DP receptor
InterPro IPR000265 Prostanoid EP3 receptor
InterPro IPR000154 Prostanoid EP3 receptor type 3
InterPro IPR008365 Prostanoid receptor
Protein Ontology PR:000001659 prostaglandin E2 receptor EP3 subtype
References
(Earliest) J:150 Sugimoto Y, et al., Cloning and expression of a cDNA for mouse prostaglandin E receptor EP3 subtype. J Biol Chem. 1992 Apr 5;267(10):6463-6
(Latest) J:220545 Lu A, et al., EP3 receptor deficiency attenuates pulmonary hypertension through suppression of Rho/TGF-beta1 signaling. J Clin Invest. 2015 Mar 2;125(3):1228-42
All references(118)
Other
accession IDs
MGD-MRK-13257, MGD-MRK-13662

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory