Ptger3
Gene Detail

Symbol Name ID

Ptger3 prostaglandin E receptor 3 (subtype EP3) MGI:97795

Synonyms

EP3, Pgerep3, Ptgerep3

Feature Type

protein coding gene

Genetic Map

Chromosome 3

81.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr3:157566892-157644758 bp, + strand From VEGA annotation of GRCm38   77867 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:105703  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: G protein-coupled prostanoid receptor
Gene Tree: Ptger3

Human homologs

Human Homolog		PTGER3, prostaglandin E receptor 3 (subtype EP3)
NCBI Gene ID		5733
neXtProt AC		NX_P43115
Human Synonyms		EP3, EP3e, EP3-I, EP3-II, EP3-III, EP3-IV, PGE2-R
Human Chr (Location)		1p31.2; chr1:71318036-71513491 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Homozygotes for targeted null mutations exhibit increased basal renal blood flow, decreased resting renal vascular resistance, impaired duodenal bicarbonate secretion and mucosal integrity, and impaired responses to endotoxin.

 

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	adenylate cyclase-modulating G-protein coupled receptor signaling pathway, bicarbonate transport, ...
Component	integral to membrane, membrane, ...
Function	G-protein coupled receptor activity, prostaglandin E receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (138)    Tissues (45)    Images (3)
Theiler Stages: 23, 28

Assay Type	Results
RT-PCR	138

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(16) cDNA(13) Primer pair(3)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000037109 (Evidence)
Ensembl Gene Model	ENSMUSG00000040016 (Evidence)
Entrez Gene	19218 (Evidence)
UniGene	30424
DFCI	TC1586711, TC1593242
DoTS	DT.101360044, DT.94124448, DT.94131249
NIA Mouse Gene Index	U004023
Consensus CDS Project	CCDS17932.1
International Mouse Knockout Project Status	Ptger3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037109	VEGA Gene Model | MGI Sequence Detail	77867	C57BL/6J
transcript	OTTMUST00000095548	VEGA | MGI Sequence Detail	2097	Not Applicable
polypeptide	OTTMUSP00000053314	VEGA | MGI Sequence Detail	366	Not Applicable

All sequences(29) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(295 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000276	G protein-coupled receptor, rhodopsin-like
InterPro	IPR001244	Prostaglandin DP receptor
InterPro	IPR000265	Prostanoid EP3 receptor
InterPro	IPR000154	Prostanoid EP3 receptor type 3
InterPro	IPR008365	Prostanoid receptor
Protein Ontology	PR:000001659	prostaglandin E2 receptor EP3 subtype

References

(Earliest) J:150 Sugimoto Y, et al., Cloning and expression of a cDNA for mouse prostaglandin E receptor EP3 subtype. J Biol Chem. 1992 Apr 5;267(10):6463-6
(Latest) J:190524 Shalom-Barak T, et al., Placental PPARgamma regulates spatiotemporally diverse genes and a unique metabolic network. Dev Biol. 2012 Dec 1;372(1):143-55
All references(110)

Other accession IDs

MGD-MRK-13257, MGD-MRK-13662