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Ptbp1 Gene Detail
Summary
  • Symbol
    Ptbp1
  • Name
    polypyrimidine tract binding protein 1
  • Synonyms
    hnRNP I, Ptb
  • Feature Type
    protein coding gene
  • IDs
    MGI:97791
    NCBI Gene: 19205
  • Gene Overview
    MyGene.info: PTBP1
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:79854432-79864435 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    13 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97791
protein coding gene Chr10:79854427-79864771 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017463
protein coding gene Chr10:80410843-80419678 (+)
A/J MGP_AJ_G0017441
protein coding gene Chr10:77608936-77619157 (+)
AKR/J MGP_AKRJ_G0017402
protein coding gene Chr10:79722188-79732528 (+)
BALB/cJ MGP_BALBcJ_G0017403
protein coding gene Chr10:77835019-77846075 (+)
C3H/HeJ MGP_C3HHeJ_G0017226
protein coding gene Chr10:79826456-79837804 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017857
protein coding gene Chr10:83184611-83195612 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015545
protein coding gene Chr10:73834597-73844955 (+)
CAST/EiJ MGP_CASTEiJ_G0016793
protein coding gene Chr10:80012293-80023135 (+)
CBA/J MGP_CBAJ_G0017198
protein coding gene Chr10:86410948-86423881 (+)
DBA/2J MGP_DBA2J_G0017304
protein coding gene Chr10:76823821-76834172 (+)
FVB/NJ MGP_FVBNJ_G0017298
protein coding gene Chr10:76002426-76011913 (+)
LP/J MGP_LPJ_G0017375
protein coding gene Chr10:80887098-80898949 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017324
protein coding gene Chr10:88383895-88394177 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017898
protein coding gene Chr10:79706105-79719961 (+)
PWK/PhJ MGP_PWKPhJ_G0016574
protein coding gene Chr10:76685900-76696071 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016363
protein coding gene Chr10:78682129-78691858 (+)
WSB/EiJ MGP_WSBEiJ_G0016853
protein coding gene Chr10:79729874-79739709 (+)



Homology
more
  • Human Ortholog
    PTBP1, polypyrimidine tract binding protein 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PTBP1, polypyrimidine tract binding protein 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HNRNPI, HNRNP-I, HNRPI, pPTB, PTB, PTB-1, PTB2, PTB3, PTB4, PTB-T
  • Links
    NCBI Gene ID: 5725
    neXtProt AC: NX_P26599
    UniProt: P26599

  • Chr Location
    19p13.3; chr19:797392-812327 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 49188
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PTBP1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 3 alleles in 3 genetic backgrounds
    4 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele die before E6.5. Mice homozygous for a conditional allele activated in neuronal stem cells (NSCs) exhibit premature death, and non-obstructive hydrocephaly with loss of ependymal cells due to precocious NSC differentiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19205 NCBI Gene Model | MGI Sequence Detail 10004 C57BL/6J ±  kb
    transcript NM_001077363 RefSeq | MGI Sequence Detail 3127 C57BL/6  
    polypeptide P17225 UniProt | EBI | MGI Sequence Detail 527 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      21 Sequences
    • InterPro Domains
      IPR006536 HnRNP-L/PTB
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR034798 Polypyrimidine tract-binding protein1/2/3, RNA recognition motif 2
      IPR035000 PTBP1, RNA recognition motif 1
      IPR035001 PTBP1, RNA recognition motif 3
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
    Molecular
    Reagents
    less
    • All nucleic 712
      Genomic 1
      cDNA 708
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13658, MGI:2143456
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 20
      Gene Ontology 8
      Phenotypes 19
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:265269 D D, et al., RBM4 Modulates Radial Migration via Alternative Splicing of Dab1 during Cortex Development. Mol Cell Biol. 2018 Jun 15;38(12)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory