Gene Expression Literature Summary

• Symbol: Ptbp1
• Name: polypyrimidine tract binding protein 1
• ID: MGI:97791

26 matching records from 26 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E6.5	E7.5	E8.5	E9	E9.5	E10.5	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16.5	E17	E17.5	E18	E18.5	P
Immunohistochemistry (section)		1			1	1	1		2		4		3		2	2		1			3
In situ RNA (section)						1			1		3		1								2
In situ RNA (whole mount)							1
In situ reporter (knock in)	1	1	1	1					1							1					1
Northern blot																					1
Western blot								2	3	1	2	1	4	2	1	3	1		1	2	10
RT-PCR									2	1	4		2	1			1		1	1	7
cDNA clones																		1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Ptbp1  polypyrimidine tract binding protein 1   (Synonyms: hnRNP I, Ptb)
Results	Reference
2*	J:291807 Belanger K, Nutter CA, Li J, Yu P, Kuyumcu-Martinez MN, A developmentally regulated spliced variant of PTBP1 is upregulated in type 1 diabetic hearts. Biochem Biophys Res Commun. 2019 Feb 5;509(2):384-389
4*	J:265269 Dhananjaya D, Hung KY, Tarn WY, RBM4 Modulates Radial Migration via Alternative Splicing of Dab1 during Cortex Development. Mol Cell Biol. 2018 Jun 15;38(12)
2	J:333262 Feng S, Wen H, Liu K, Xiong M, Li J, Gui Y, Lv C, Zhang J, Ma X, Wang X, Yuan S, hnRNPH1 establishes Sertoli-germ cell crosstalk through cooperation with PTBP1 and AR, and is essential for male fertility in mice. Development. 2023 Feb 15;150(3):dev201040
1	J:93248 Hamatani T, Falco G, Carter MG, Akutsu H, Stagg CA, Sharov AA, Dudekula DB, VanBuren V, Ko MS, Age-associated alteration of gene expression patterns in mouse oocytes. Hum Mol Genet. 2004 Nov 1;13(19):2263-78
2*	J:142671 Kalsotra A, Xiao X, Ward AJ, Castle JC, Johnson JM, Burge CB, Cooper TA, A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart. Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20333-8
2	J:169234 Kim JD, Kim H, Ekram MB, Yu S, Faulk C, Kim J, Rex1/Zfp42 as an epigenetic regulator for genomic imprinting. Hum Mol Genet. 2011 Apr 1;20(7):1353-62
1	J:100326 Kleinhenz B, Fabienke M, Swiniarski S, Wittenmayer N, Kirsch J, Jockusch BM, Arnold HH, Illenberger S, Raver2, a new member of the hnRNP family. FEBS Lett. 2005 Aug 15;579(20):4254-8
2	J:98810 Ladd AN, Stenberg MG, Swanson MS, Cooper TA, Dynamic balance between activation and repression regulates pre-mRNA alternative splicing during heart development. Dev Dyn. 2005 Apr 13;233(3):783-793
3*	J:137591 Lahmann I, Fabienke M, Henneberg B, Pabst O, Vauti F, Minge D, Illenberger S, Jockusch BM, Korte M, Arnold HH, The hnRNP and cytoskeletal protein raver1 contributes to synaptic plasticity. Exp Cell Res. 2008 Mar 10;314(5):1048-60
8	J:95310 Lepourcelet M, Tou L, Cai L, Sawada J, Lazar AJ, Glickman JN, Williamson JA, Everett AD, Redston M, Fox EA, Nakatani Y, Shivdasani RA, Insights into developmental mechanisms and cancers in the mammalian intestine derived from serial analysis of gene expression and study of the hepatoma-derived growth factor (HDGF). Development. 2005 Jan;132(2):415-27
4*	J:68159 Lillevali K, Kulla A, Ord T, Comparative expression analysis of the genes encoding polypyrimidine tract binding protein (PTB) and its neural homologue (brPTB) in prenatal and postnatal mouse brain. Mech Dev. 2001 Mar;101(1-2):217-20
5	J:253164 Lin JC, Lu YH, Liu YR, Lin YJ, RBM4a-regulated splicing cascade modulates the differentiation and metabolic activities of brown adipocytes. Sci Rep. 2016 Feb 9;6:20665
7	J:297779 Lin L, Zhang M, Stoilov P, Chen L, Zheng S, Developmental Attenuation of Neuronal Apoptosis by Neural-Specific Splicing of Bak1 Microexon. Neuron. 2020 Sep 23;107(6):1180-1196.e8
5	J:334567 Liu H, Duan R, He X, Qi J, Xing T, Wu Y, Zhou L, Wang L, Shao Y, Zhang F, Zhou H, Gu X, Lin B, Liu Y, Wang Y, Liu Y, Li L, Liang D, Chen YH, Endothelial deletion of PTBP1 disrupts ventricular chamber development. Nat Commun. 2023 Mar 31;14(1):1796
5	J:268025 Makeyev EV, Zhang J, Carrasco MA, Maniatis T, The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing. Mol Cell. 2007 Aug 3;27(3):435-48
4*	J:103446 McKee AE, Minet E, Stern C, Riahi S, Stiles CD, Silver PA, A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. BMC Dev Biol. 2005 Jul 20;5:14
4	J:215543 Raj B, Irimia M, Braunschweig U, Sterne-Weiler T, O'Hanlon D, Lin ZY, Chen GI, Easton LE, Ule J, Gingras AC, Eyras E, Blencowe BJ, A global regulatory mechanism for activating an exon network required for neurogenesis. Mol Cell. 2014 Oct 2;56(1):90-103
8	J:213479 Shibasaki T, Tokunaga A, Sakamoto R, Sagara H, Noguchi S, Sasaoka T, Yoshida N, PTB deficiency causes the loss of adherens junctions in the dorsal telencephalon and leads to lethal hydrocephalus. Cereb Cortex. 2013 Aug;23(8):1824-35
9*	J:223915 Suckale J, Wendling O, Masjkur J, Jager M, Munster C, Anastassiadis K, Stewart AF, Solimena M, PTBP1 is required for embryonic development before gastrulation. PLoS One. 2011;6(2):e16992
1*	J:238787 Tahmasebi S, Jafarnejad SM, Tam IS, Gonatopoulos-Pournatzis T, Matta-Camacho E, Tsukumo Y, Yanagiya A, Li W, Atlasi Y, Caron M, Braunschweig U, Pearl D, Khoutorsky A, Gkogkas CG, Nadon R, Bourque G, Yang XJ, Tian B, Stunnenberg HG, Yamanaka Y, Blencowe BJ, Giguere V, Sonenberg N, Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2. Proc Natl Acad Sci U S A. 2016 Nov 01;113(44):12360-12367
2	J:323057 Verdile V, Svetoni F, La Rosa P, Ferrante G, Cesari E, Sette C, Paronetto MP, EWS splicing regulation contributes to balancing Foxp1 isoforms required for neuronal differentiation. Nucleic Acids Res. 2022 Apr 8;50(6):3362-3378
1	J:239441 Vuong JK, Lin CH, Zhang M, Chen L, Black DL, Zheng S, PTBP1 and PTBP2 Serve Both Specific and Redundant Functions in Neuronal Pre-mRNA Splicing. Cell Rep. 2016 Dec 06;17(10):2766-2775
3	J:184828 Yap K, Lim ZQ, Khandelia P, Friedman B, Makeyev EV, Coordinated regulation of neuronal mRNA steady-state levels through developmentally controlled intron retention. Genes Dev. 2012 Jun 1;26(11):1209-23
1	J:235479 Yap K, Xiao Y, Friedman BA, Je HS, Makeyev EV, Polarizing the Neuron through Sustained Co-expression of Alternatively Spliced Isoforms. Cell Rep. 2016 May 10;15(6):1316-28
1*	J:235839 Zagore LL, Grabinski SE, Sweet TJ, Hannigan MM, Sramkoski RM, Li Q, Licatalosi DD, RNA Binding Protein Ptbp2 Is Essential for Male Germ Cell Development. Mol Cell Biol. 2015 Dec;35(23):4030-42
5	J:236302 Zhang X, Chen MH, Wu X, Kodani A, Fan J, Doan R, Ozawa M, Ma J, Yoshida N, Reiter JF, Black DL, Kharchenko PV, Sharp PA, Walsh CA, Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex. Cell. 2016 Aug 25;166(5):1147-1162.e15