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Psap Gene Detail
Summary
  • Symbol
    Psap
  • Name
    prosaposin
  • Synonyms
    SGP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97783
    NCBI Gene: 19156
  • Gene Overview
    MyGene.info: PSAP
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:60277627-60302594 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24968 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 30.02 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    PSAP, prosaposin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PSAP, prosaposin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GLBA, SAP1
  • Links
    NCBI Gene ID: 5660
    neXtProt AC: NX_P07602
    UniProt: P07602

  • Chr Location
    10q22.1; chr10:71816283-71851375 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 37680
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PSAP
  • Protein SuperFamily
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Psap mouse models; 2 with human PSAP associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    131 phenotypes from 8 alleles in 7 genetic backgrounds
    1 phenotype from multigenic genotypes
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation die either neonatally or around 7 weeks. At 30 days, mutants show hypomyelination, PAS-positive material in the nervous system, and accumulation of ceramides in brain, liver, and kidney.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000016474 VEGA Gene Model | MGI Sequence Detail 24968 C57BL/6J ±  kb
    transcript OTTMUST00000039727 VEGA | MGI Sequence Detail 2646 Not Applicable  
    polypeptide OTTMUSP00000017725 VEGA | MGI Sequence Detail 554 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      237 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 1562
      Genomic 2
      cDNA 1556
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13645, MGI:2143518
    References
    more
    • Summaries
      All 98
      Developmental Gene Expression 12
      Diseases 3
      Gene Ontology 9
      Phenotypes 47
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:249356 Ishihara S, et al., Mechano-Signal Transduction in Mesenchymal Stem Cells Induces Prosaposin Secretion to Drive the Proliferation of Breast Cancer Cells. Cancer Res. 2017 Nov 15;77(22):6179-6189

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory