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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Psap
prosaposin
MGI:97783
141 phenotypes from 10 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Psapm1Btlr/Psapm1Btlr
C57BL/6J-Psapm1Btlr 		ataxia J:267559
Psaptm1Ggb/Psaptm1Ggb
involves: 129S/SvEv * C57BL/6J 		abnormal behavior J:121761
abnormal forebrain morphology J:121761
abnormal lipid level J:121761
abnormal microglial cell physiology J:121761
abnormal myelination J:121761
abnormal reproductive system physiology J:121761
abnormal spleen morphology J:121761
abnormal telencephalon morphology J:121761
ataxia J:121761
axon degeneration J:121761
hindlimb paralysis J:121761
kyphosis J:121761
normal nervous system phenotype J:121761
neuron degeneration J:121761
neuronal intranuclear inclusions J:121761
premature death J:121761
Purkinje cell degeneration J:121761
normal renal/urinary system phenotype J:121761
straub tail J:121761
weight loss J:121761
Psaptm1Juma/Psaptm1Juma
FVB.129S-Psaptm1Juma 		abnormal brainstem morphology J:121761
abnormal microglial cell physiology J:121761
abnormal myelination J:121761
premature death J:121761
Psaptm1Juma/Psaptm1Juma
involves: 129S/SvEv * C57BL/6J 		abnormal gait J:94408
abnormal kidney cortex morphology J:94408
abnormal motor coordination/balance J:94408
abnormal renal tubule morphology J:94408
ataxia J:94408
hydronephrosis J:94408
polydipsia J:94408
polyuria J:94408
premature death J:94408
Purkinje cell degeneration J:94408
small cerebellum J:94408
Psaptm1Mhor/Psaptm1Mhor
either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) 		no abnormal phenotype detected J:97577
Psaptm1Suz/Psap+
involves: 129P2/OlaHsd * FVB 		abnormal cochlea morphology J:116349
Psaptm1Suz/Psaptm1Suz
B6.129P2-Psaptm1Suz 		abnormal lipid level J:120657
normal homeostasis/metabolism phenotype J:120657
premature death J:120657
prenatal lethality, incomplete penetrance J:120657
normal reproductive system phenotype J:120657
Psaptm1Suz/Psaptm1Suz
involves: 129P2/OlaHsd 		abnormal astrocyte morphology J:113052
abnormal brain white matter morphology J:33477
abnormal choroid plexus morphology J:113052
abnormal circulating testosterone level J:106511
abnormal corneal stroma morphology J:113052
abnormal dorsal root ganglion morphology J:113052
abnormal enteric ganglia morphology J:113052
abnormal enzyme/coenzyme level J:283977
abnormal epididymis morphology J:106511
abnormal eye morphology J:113052
abnormal food intake J:113052
abnormal gait J:113052
abnormal head movements J:33477
abnormal hepatocyte morphology J:113052
abnormal lipid homeostasis J:33477
abnormal lipid level J:78223
abnormal macrophage morphology J:113052
abnormal muscle fiber morphology J:113052
abnormal nervous system morphology J:113052
abnormal neuron morphology J:113052
abnormal prostate gland epithelium morphology J:106511
abnormal prostate gland morphology J:106511
abnormal renal tubule morphology J:113052
abnormal Schwann cell morphology J:113052
abnormal seminal vesicle morphology J:106511
abnormal vascular endothelial cell morphology J:113052
astrocytosis J:113052
ataxia J:33477
axon degeneration J:113052
axonal spheroids J:113052
decreased body size J:33477
decreased body weight J:113052
decreased epididymis weight J:106511
decreased kidney weight J:106511
decreased liver weight J:106511
decreased locomotor activity J:113052
decreased male germ cell number J:106511
decreased prostate gland weight J:106511
decreased seminal vesicle weight J:106511
decreased spleen weight J:106511
decreased testis weight J:106511
demyelination J:33477
head shaking J:33477
hindlimb paralysis J:113052
hyperactivity J:113052
increased beta-galactosidase level J:283977
lethality at weaning, complete penetrance J:33477
muscular atrophy J:113052
neonatal lethality, incomplete penetrance J:33477
paraparesis J:113052
prenatal lethality, incomplete penetrance J:33477
progressive muscle weakness J:33477
seizures J:113052
slow postnatal weight gain J:113052
small kidney J:33477
tonic seizures J:33477
tremors J:33477, J:113052
Psaptm1Suz/Psaptm1Suz
involves: 129P2/OlaHsd * C57BL/6J 		abnormal myelination J:121761
Psaptm1Suz/Psaptm1Suz
involves: 129P2/OlaHsd * FVB 		abnormal cochlea morphology J:116349
abnormal cochlear IHC afferent innervation pattern J:116349
abnormal cochlear IHC efferent innervation pattern J:116349
abnormal cochlear inner hair cell morphology J:116349
abnormal cochlear OHC efferent innervation pattern J:116349
abnormal cochlear outer hair cell physiology J:116349
abnormal Deiters cell morphology J:116349
abnormal organ of Corti morphology J:116349
cochlear outer hair cell degeneration J:116349
deafness J:116349
decreased distortion product otoacoustic emission amplitude J:116349
increased or absent threshold for auditory brainstem response J:116349
sensorineural hearing loss J:116349
Psaptm1Suz/Psaptm2.1Juma
involves: 129 * 129P2/OlaHsd * C57BL/6J * FVB/N 		abnormal cerebellar granule cell morphology J:283977
abnormal cerebellar granule layer morphology J:283977
abnormal cerebellar molecular layer J:283977
abnormal gait J:283977
abnormal motor capabilities/coordination/movement J:283977
abnormal vascular endothelial cell morphology J:283977
astrocytosis J:283977
axonal spheroids J:283977
decreased cerebellar granule cell number J:283977
normal hematopoietic system phenotype J:283977
normal homeostasis/metabolism phenotype J:283977
impaired coordination J:283977
limb grasping J:283977
normal liver/biliary system phenotype J:283977
nervous system inclusion bodies J:283977
Purkinje cell degeneration J:283977
normal reproductive system phenotype J:283977
tremors J:283977
Psaptm2.1Juma/Psaptm2.1Juma
involves: 129 * C57BL/6J * FVB/N 		abnormal cerebellar granule cell morphology J:283977
abnormal cerebellar granule layer morphology J:283977
abnormal cerebellar molecular layer J:283977
abnormal enzyme/coenzyme level J:283977
abnormal gait J:283977
abnormal motor capabilities/coordination/movement J:283977
abnormal vascular endothelial cell morphology J:283977
astrocytosis J:283977
axonal spheroids J:283977
decreased cerebellar granule cell number J:283977
normal hematopoietic system phenotype J:283977
normal homeostasis/metabolism phenotype J:283977
impaired coordination J:283977
limb grasping J:283977
normal liver/biliary system phenotype J:283977
nervous system inclusion bodies J:283977
Purkinje cell degeneration J:283977
normal reproductive system phenotype J:283977
tremors J:283977
Psaptm2Ggb/Psaptm2Ggb
involves: 129S/SvEv * C57BL/6J 		abnormal kidney physiology J:137650
abnormal nervous system physiology J:137650
abnormal neuron physiology J:137650
abnormal respiratory system physiology J:137650
abnormal urine homeostasis J:137650
ataxia J:137650
normal behavior/neurological phenotype J:137650
CNS inflammation J:137650
decreased body weight J:137650
impaired balance J:137650
impaired coordination J:137650
kidney inflammation J:137650
limb grasping J:137650
microgliosis J:198242
normal nervous system phenotype J:137650
premature death J:198242
tremors J:137650, J:198242
Psaptm2Suz/Psaptm2Suz
involves: 129S/SvEv * C57BL/6J 		abnormal brain white matter morphology J:78223
abnormal brainstem morphology J:78223
abnormal cerebellum morphology J:78223
abnormal enzyme/coenzyme activity J:78223
abnormal gait J:73188, J:78223
abnormal habituation J:198242
abnormal intestinal peristalsis J:78223
abnormal involuntary movement J:78223
abnormal lipid level J:73188, J:78223, J:120657
abnormal liver morphology J:198242
abnormal macrophage morphology J:78223
abnormal myelin sheath morphology J:73188
abnormal nervous system morphology J:73188, J:78223
abnormal Schwann cell morphology J:78223
abnormal spinal cord morphology J:78223
abnormal ventral spinal root morphology J:78223
CNS inflammation J:78223
decreased locomotor activity J:78223, J:198242
demyelination J:73188, J:78223
enhanced autophagy J:198242
hindlimb paralysis J:78223
normal homeostasis/metabolism phenotype J:120657
hyperactivity J:78223, J:198242
impaired coordination J:198242
increased spinal cord size J:78223
microgliosis J:198242
muscle weakness J:78223
muscular atrophy J:78223
neurogenic bladder J:78223
neuronal intranuclear inclusions J:78223
premature death J:73188, J:78223, J:198242
seizures J:78223
short stride length J:73188
Psaptm3.1Ggb/Psaptm3.1Ggb
involves: 129S/SvEv * C57BL/6J 		abnormal axon morphology J:155864
abnormal dorsal root ganglion morphology J:155864
abnormal hippocampus granule cell layer J:155864
abnormal innervation J:155864
astrocytosis J:155864
ataxia J:155864
axonal spheroids J:155864
decreased anxiety-related response J:155864
decreased Purkinje cell number J:155864
demyelination J:155864
hindlimb paralysis J:155864
impaired coordination J:155864
impaired limb coordination J:155864
increased vertical activity J:155864
limb grasping J:155864
paraparesis J:155864
reduced long-term potentiation J:155864
small cerebellum J:155864
Psaptm4.1Ggb/Psaptm4.1Ggb
involves: 129S/SvEv * C57BL/6J 		abnormal distal convoluted tubule morphology J:198242
abnormal habituation J:198242
abnormal lipid homeostasis J:198242
abnormal liver morphology J:198242
abnormal locomotor behavior J:198242
abnormal neuron morphology J:198242
abnormal vascular endothelial cell morphology J:198242
amyloid beta deposits J:198242
astrocytosis J:198242
decreased locomotor activity J:198242
enhanced autophagy J:198242
hyperactivity J:198242
impaired coordination J:198242
limb grasping J:198242
microgliosis J:198242
normal nervous system phenotype J:198242
premature death J:198242
tremors J:198242
weight loss J:198242
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory