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Prps1 Gene Detail
Summary
  • Symbol
    Prps1
  • Name
    phosphoribosyl pyrophosphate synthetase 1
  • Synonyms
    2310010D17Rik, Prps-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97775
    NCBI Gene: 19139
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:140456613-140476140 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 61.35 cM, cytoband F1-F2
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    72 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97775
protein coding gene ChrX:140456603-140476140 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036134
protein coding gene ChrX:138005983-138026861 (+)
A/J MGP_AJ_G0036112
protein coding gene ChrX:137383207-137405329 (+)
AKR/J MGP_AKRJ_G0036037
protein coding gene ChrX:141784467-141804998 (+)
BALB/cJ MGP_BALBcJ_G0036102
protein coding gene ChrX:135697938-135717554 (+)
C3H/HeJ MGP_C3HHeJ_G0035811
protein coding gene ChrX:138014918-138035061 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036627
protein coding gene ChrX:142049193-142071191 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033451
protein coding gene ChrX:129107450-129130473 (+)
CAST/EiJ MGP_CASTEiJ_G0035102
protein coding gene ChrX:118832307-118852575 (+)
CBA/J MGP_CBAJ_G0035788
protein coding gene ChrX:146413983-146436456 (+)
DBA/2J MGP_DBA2J_G0035945
protein coding gene ChrX:136526543-136546278 (+)
FVB/NJ MGP_FVBNJ_G0035879
protein coding gene ChrX:135759712-135780187 (+)
LP/J MGP_LPJ_G0036036
protein coding gene ChrX:138957048-138976513 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035916
protein coding gene ChrX:153926643-153948855 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036663
protein coding gene ChrX:137311994-137331506 (+)
PWK/PhJ MGP_PWKPhJ_G0034795
protein coding gene ChrX:115735488-115755776 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034621
protein coding gene ChrX:119373827-119393361 (+)
WSB/EiJ MGP_WSBEiJ_G0035237
protein coding gene ChrX:135636322-135655753 (+)



Homology
more
  • Human Ortholog
    PRPS1, phosphoribosyl pyrophosphate synthetase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PRPS1, phosphoribosyl pyrophosphate synthetase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARTS, CMTX5, DFN2, DFNX1, PPRibP, PRSI, PRS-I
  • Links
    NCBI Gene ID: 5631
    neXtProt AC: NX_P60891
    UniProt: P60891

  • Chr Location
    Xq22.3; chrX:107628424-107651026 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    4 with human PRPS1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031432 Ensembl Gene Model | MGI Sequence Detail 19528 C57BL/6J ±  kb
transcript ENSMUST00000033809 Ensembl | MGI Sequence Detail 1965 Not Applicable  
polypeptide ENSMUSP00000033809 Ensembl | MGI Sequence Detail 318 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000013291 ribose-phosphate pyrophosphokinase 1
  • EC
  • InterPro Domains
    IPR000842 Phosphoribosyl pyrophosphate synthetase, conserved site
    IPR000836 Phosphoribosyltransferase domain
    IPR029057 Phosphoribosyltransferase-like
    IPR005946 Ribose-phosphate pyrophosphokinase
    IPR037515 Ribose-phosphate pyrophosphokinase, bacterial-type
    IPR029099 Ribose-phosphate pyrophosphokinase, N-terminal domain
Molecular
Reagents
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  • All nucleic 154
    cDNA 152
    Primer pair 1
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-13629, MGD-MRK-13631, MGI:1913803, MGI:2145078, MGI:2148046
References
more
  • Summaries
    All 52
    Developmental Gene Expression 7
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:9641 Taira M, et al., Tissue-differential expression of two distinct genes for phosphoribosyl pyrophosphate synthetase and existence of the testis-specific transcript. Biochim Biophys Acta. 1989 Mar 1;1007(2):203-8
  • Latest
    J:240028 Bulusu V, et al., Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Dev Cell. 2017 Feb 27;40(4):331-341.e4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory