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Prps1
Gene Detail
 Symbol
Name
ID
Prps1
phosphoribosyl pyrophosphate synthetase 1
MGI:97775
Synonyms 2310010D17Rik, Prps-1
Feature Type protein coding gene
Genetic Map
Chromosome X
61.35 cM, cytoband F1-F2
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
ChrX:140456613-140476140 bp, + strand
From VEGA annotation of GRCm38

  19528 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68275  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: ribose-phosphate pyrophosphokinase catalytic chain
Gene Tree: Prps1

Human
homologs
Human Homolog PRPS1, phosphoribosyl pyrophosphate synthetase 1
NCBI Gene ID 5631
neXtProt AC  NX_P60891
Human Synonyms  ARTS, CMTX5, DFN2, DFNX1, PPRibP, PRSI, PRS-I
Human Chr (Location)  Xq22.3; chrX:107628424-107651026 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human PRPS1
Alleles
and
phenotypes
All alleles(10) : Targeted(4) Gene trapped(6)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process 5-phosphoribose 1-diphosphate biosynthetic process, AMP biosynthetic process, ...
Component protein complex, ribose phosphate diphosphokinase complex
Function ADP binding, AMP binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (143)    Tissues (129)    Images (13)
Theiler Stages: 19, 22, 23, 26, 28
Assay TypeResults
RNA in situ 143
cDNA source data(142)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(152) cDNA(151) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000018847 (Evidence)
Ensembl Gene ModelENSMUSG00000031432 (Evidence)
Entrez Gene19139 (Evidence)
UniGene287178
DFCITC1572483, TC1596743
DoTSDT.55101019, DT.94357997
EC2.7.6.1
Consensus CDS ProjectCCDS30439.1
International Mouse Knockout Project StatusPrps1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018847 VEGA Gene Model | MGI Sequence Detail 19528 C57BL/6J ±  kb
transcript OTTMUST00000045356 VEGA | MGI Sequence Detail 1965 Not Applicable 
polypeptide OTTMUSP00000020407 VEGA | MGI Sequence Detail 318 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(2) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(72 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000842 Phosphoribosyl pyrophosphate synthetase, conserved site
InterPro IPR005946 Ribose-phosphate diphosphokinase
Protein Ontology PR:000013291 ribose-phosphate pyrophosphokinase 1
References (Earliest) J:9641 Taira M, et al., Tissue-differential expression of two distinct genes for phosphoribosyl pyrophosphate synthetase and existence of the testis-specific transcript. Biochim Biophys Acta. 1989 Mar 1;1007(2):203-8
(Latest) J:186646 Ekdahl Y, et al., A-to-I editing of microRNAs in the mammalian brain increases during development. Genome Res. 2012 Aug;22(8):1477-87
All references(48)
Other
accession IDs
MGD-MRK-13629, MGD-MRK-13631, MGI:1913803, MGI:2145078, MGI:2148046

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory