Prps1
Gene Detail

Symbol Name ID

Prps1 phosphoribosyl pyrophosphate synthetase 1 MGI:97775

Synonyms

2310010D17Rik, Prps-1

Feature Type

protein coding gene

Genetic Map

Chromosome X

61.35 cM, cytoband F1-F2
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

ChrX:140456613-140476140 bp, + strand From VEGA annotation of GRCm38   19528 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68275  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: ribose-phosphate pyrophosphokinase catalytic chain
Gene Tree: Prps1

Human homologs

Human Homolog		PRPS1, phosphoribosyl pyrophosphate synthetase 1
NCBI Gene ID		5631
neXtProt AC		NX_P60891
Human Synonyms		ARTS, CMTX5, DFN2, DFNX1, PPRibP, PRSI, PRS-I
Human Chr (Location)		Xq21.32-q24; chrX:106871654-106894256 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(9) : Targeted(3) Gene trapped(6)

Gene Ontology (GO) classifications

All GO classifications: (29 annotations)

Process	5-phosphoribose 1-diphosphate biosynthetic process, AMP biosynthetic process, ...
Component	protein complex, ribose phosphate diphosphokinase complex
Function	ADP binding, AMP binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (143)    Tissues (129)    Images (13)
Theiler Stages: 19, 22, 23, 26, 28

Assay Type	Results
RNA in situ	143

cDNA source data(142)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(152) cDNA(151) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000018847 (Evidence)
Ensembl Gene Model	ENSMUSG00000031432 (Evidence)
Entrez Gene	19139 (Evidence)
UniGene	287178
DFCI	TC1572483, TC1596743
DoTS	DT.55101019, DT.94357997
EC	2.7.6.1
Consensus CDS Project	CCDS30439.1
International Mouse Knockout Project Status	Prps1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018847	VEGA Gene Model | MGI Sequence Detail	19528	C57BL/6J
transcript	OTTMUST00000045356	VEGA | MGI Sequence Detail	1965	Not Applicable
polypeptide	OTTMUSP00000020407	VEGA | MGI Sequence Detail	318	Not Applicable

All sequences(38) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(63 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000842	Phosphoribosyl pyrophosphate synthetase, conserved site
InterPro	IPR000836	Phosphoribosyltransferase domain
InterPro	IPR005946	Ribose-phosphate diphosphokinase
Protein Ontology	PR:000013291	ribose-phosphate pyrophosphokinase 1

References

(Earliest) J:9641 Taira M, et al., Tissue-differential expression of two distinct genes for phosphoribosyl pyrophosphate synthetase and existence of the testis-specific transcript. Biochim Biophys Acta. 1989 Mar 1;1007(2):203-8
(Latest) J:186646 Ekdahl Y, et al., A-to-I editing of microRNAs in the mammalian brain increases during development. Genome Res. 2012 Aug;22(8):1477-87
All references(47)

Other accession IDs

MGD-MRK-13629, MGD-MRK-13631, MGI:1913803, MGI:2145078, MGI:2148046